A critical review of bioactive glasses and glass–ceramics in cancer therapy

Moeini, Ali; Chinijani, Turan Hassanzadeh; Khachatourian, Adrine Malek; Fook, Marcus Vinícius Lia; Baino, Francesco; Montazerian, Maziar

doi:10.1111/ijag.16601

Cited by 35 publications

(14 citation statements)

References 200 publications

(508 reference statements)

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“…Additionally, the sol–gel method is more time‐consuming than the melt‐quenching route and carries the challenge of managing the environmentally problematic organic precursors required for advancing the reactions. Regardless of the synthesis protocol, BGs can be used in medical applications from orthopedics/dental repair (Jones et al, 2016) to cancer therapy (Moeini et al, 2022) in various shapes and forms, either alone or in combination with other biocompatible materials (e.g., biopolymers).…”

Section: Bioactive Glasses (Bgs): From Micro‐ To Nano‐scalementioning

confidence: 99%

Nanostructured bioactive glasses: A bird's eye view on cancer therapy

Kargozar

Moghanian

Rashvand

et al. 2023

WIREs Nanomed Nanobiotechnol

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Bioactive glasses (BGs) arewell known for their successful applications in tissue engineering and regenerative medicine. Recent experimental studies have shown their potential usability in oncology, either alone or in combination with other biocompatible materials, such as biopolymers. Direct contact with BG particles has been found to cause toxicity and death in specific cancer cells (bone‐derived neoplastic stromal cells) in vitro. Nanostructured BGs (NBGs) can be doped with anticancer elements, such as gallium, to enhance their toxic effects against tumor cells. However, the molecular mechanisms and intracellular targets for anticancer compositions of NBGs require further clarification. NBGs have been successfully evaluated for use in various well‐established cancer treatment strategies, including cancer hyperthermia, phototherapy, and anticancer drug delivery. Existing results indicate that NBGs not only enhance cancer cell death, but can also participate in the regeneration of lost healthy tissues. However, the application of NBGs in oncology is still in its early stages, and numerous unanswered questions must be addressed. For example, the impact of the composition, biodegradation, size, and morphology of NBGs on their anticancer efficacy should be defined for each type of cancer and treatment strategy. Moreover, it should be more clearly assessed whether NBGs can shrink tumors, slow/stop cancer progression, or cure cancer completely. In this regard, the use of computational studies (in silico methods) is highly recommended to design the most effective glass formulations for cancer therapy approaches and to predict, to some extent, the relevant properties, efficacy, and outcomes.This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Section: Bioactive Glasses (Bgs): From Micro‐ To Nano‐scalementioning

confidence: 99%

Nanostructured bioactive glasses: A bird's eye view on cancer therapy

Kargozar

Moghanian

Rashvand

et al. 2023

WIREs Nanomed Nanobiotechnol

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“…Similar to magnetic hyperthermia, photothermal therapies utilize lasers to induce local heating around an implanted bioactive glass or glass-ceramic device. 101 Crystallizing biocompatible phases with metals such as bismuth or copper will create a device with photothermal properties. Bi/Cudoped bioactive glasses have already shown promising results killing over 80% of human osteosarcoma cells with near-IR lasers.…”

Section: Photothermal Therapiesmentioning

confidence: 99%

Perspectives on the impact of crystallization in bioactive glasses and glass‐ceramics

Montazerian,

Shearer,

Mauro

2023

Int J Ceramic Engine & Sci

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Both unwanted and induced crystallization can impact bioactivity, physical and mechanical properties of bioactive glasses (BGs). Uncontrolled crystallization has negative consequences, rendering BGs unreliable. However, by manipulating the type, size, shape, and quantity of crystals in BGs, plenty of opportunities arise for controlling, for example, mechanical properties and degradability, leading to unique applications and improved performance. Understanding crystallization is a key step in developing bioactive glasses and glass‐ceramics (BGCs), and both fundamental and experimental research can aid in the design of BGCs for processing and biological function. In this perspective, we discuss the sources of crystallization and how controlled crystallization facilitates the functionalization of bioactive scaffolds, hybrids, coatings, composites, cements, and fibers.

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“…This material, trademarked as Eye90 Microsphere™ glass, is being commercialized by ABK Biomedical Co. [ 165 , 166 , 167 ]. To learn more about radiopaque BGs for targeting cancer, interested readers can refer to a recent review by Moeini et al [ 168 ].…”

Section: Radiopacifiers In Glasses and Glass-ceramicsmentioning

confidence: 99%

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

et al. 2022

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Radiopacity is sometimes an essential characteristic of biomaterials that can help clinicians perform follow-ups during pre- and post-interventional radiological imaging. Due to their chemical composition and structure, most bioceramics are inherently radiopaque but can still be doped/mixed with radiopacifiers to increase their visualization during or after medical procedures. The radiopacifiers are frequently heavy elements of the periodic table, such as Bi, Zr, Sr, Ba, Ta, Zn, Y, etc., or their relevant compounds that can confer enhanced radiopacity. Radiopaque bioceramics are also intriguing additives for biopolymers and hybrids, which are extensively researched and developed nowadays for various biomedical setups. The present work aims to provide an overview of radiopaque bioceramics, specifically crystalline, non-crystalline (glassy), and nanostructured bioceramics designed for applications in orthopedics, dentistry, and cancer therapy. Furthermore, the modification of the chemical, physical, and biological properties of parent ceramics/biopolymers due to the addition of radiopacifiers is critically discussed. We also point out future research lacunas in this exciting field that bioceramists can explore further.

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A critical review of bioactive glasses and glass–ceramics in cancer therapy

Cited by 35 publications

References 200 publications

Nanostructured bioactive glasses: A bird's eye view on cancer therapy

Nanostructured bioactive glasses: A bird's eye view on cancer therapy

Perspectives on the impact of crystallization in bioactive glasses and glass‐ceramics

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

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