A critical review of recent advances in hemodialysis membranes hemocompatibility and guidelines for future development

Mollahosseini, Arash; Abdelrasoul, Amira; Shoker, Ahmed

doi:10.1016/j.matchemphys.2020.122911

Cited by 99 publications

(83 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This membrane also showed improvement against protein fouling (bovine serum albumin and lysozyme) compared to the unmodified membrane. Our research group also investigated the chemical groups responsible for enhancing dialysis membrane hemocompatibility 20 , 21 . The extent of protein adsorption on the polysulfone membrane surface hydrophilized with PVP has also been investigated with fibrinogen and human serum albumin (HSA) 21 .…”

Section: Introductionmentioning

confidence: 99%

“…Our research group also investigated the chemical groups responsible for enhancing dialysis membrane hemocompatibility 20 , 21 . The extent of protein adsorption on the polysulfone membrane surface hydrophilized with PVP has also been investigated with fibrinogen and human serum albumin (HSA) 21 . HSA adsorption was inhibited compared to fibrinogen due to the membrane’s hydrophilic surface.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Case studies of clinical hemodialysis membranes: influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers

Westphalen

Saadati

Eduok

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

End stage renal disease (ESRD) patients depend on hemodialysis (HD) as a life-sustaining treatment, but HD membrane properties play a critical role in blood activation during HD and can lead to severe patient outcomes. This study reports on a series of investigations on the common clinical HD membranes available in Canadian hospitals to explore the key reasons behind their susceptibility to blood activation and unstable cytokine. Clinical HD membranes composed of cellulose triacetate (CTA) and polyvinylpyrrolidone: polyarylethersulfone (PAES: PVP) were thoroughly characterized in terms of morphology and chemical composition. Membrane-surface interactions with uremic blood samples after HD treatment were probed using Fourier Transform Infra-Red (FTIR) and Raman spectroscopic techniques in order to understand changes in chemistry on membrane fibers. In addition, as part of this innovative study, we utilized Molecular Modeling Docking to examine the interactions of human blood proteins and membrane models to gain an in-depth understanding of functional group types responsible for perceived interactions. In-vitro adsorption of fibrinogen on different clinical HD membranes was compared at similar clinical operating conditions. Samples were collected from dialysis patients to ascertain the extent of inflammatory biomarkers released, before, during (30 and 90 min) and after dialysis (4 h). Collected blood samples were analyzed using Luminex assays for the inflammatory biomarkers of Serpin/Antithrombin-III, Properdin, C5a, 1L-1α, 1L-1β, TNF-α, IL6, and vWF. We have likewise incubated uremic blood in vitro with the two membrane materials to determine the impact that membrane materials pose in favor of activation away from the hydrodynamics influences. The results of our morphological, chemical, spectroscopic, and in vitro incubation analyses indicate that CTA membranes have a smoother surface and higher biocompatibility than PAES: PVP membranes, however, it has smaller pore size distribution, which results in poor clearance of a broad spectrum of uremic toxins. However, the rougher surface and greater hydrophilicity of PAES: PVP membranes increases red blood cell rupture at the membrane surface, which promotes protein adsorption and biochemical cascade reactions. Molecular docking studies indicate sulfone functional groups play an important role in the adsorption of proteins and receptors. PAES: PVP membranes result in slower but greater adsorption of fibrinogen, but are more likely to experience reversible and irreversible fouling as well as backfiltration. Our major finding is that a single dialysis session, even with a more biocompatible membrane such as CTA, increases the levels of complement and inflammation factors, but to a milder extent than dialysis with a PAES membrane.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Case studies of clinical hemodialysis membranes: influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers

Westphalen

Saadati

Eduok

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…The synthetic membranes are widely diffused, mainly as combination of different materials on distinct layers aimed to improve both purification performances and biocompatibility. Interactions of blood‐polymeric membranes lead to various system activations, including coagulation of blood, leukocytes and complement activations, cytokine production, and production of free oxygen radicals that should be carefully evaluated when choosing a membrane 8 . The bundle of semipermeable hollow fibers with the filter length defines the most generic variable utilized to characterize the dialyzer surface area (A) in square meters (m 2 ).…”

Section: Figurementioning

confidence: 99%

The Dialyzer Identification Code (DIC): A filter characteristics codification for dialyzer choice in renal replacement therapy

et al. 2020

View full text Add to dashboard Cite

The dialyzer is the core element of extracorporeal blood purification therapies where several processes take place depending on specific membrane characteristics. To date, the filter choice requires preliminary knowledge of all its characteristics as they cannot be easily deduced from the commercial trade name, hence the difficulty in identifying easily equivalent dialyzers and clearly comparing single‐filter characteristics. The choice of improper dialyzers for a specific treatment can determine a less‐effective blood purification and potentially harmful treatments. We aimed to propose a univocal and standardized alphanumeric string to summarize essential filter properties in the Dialyzer Identification Code (DIC). DIC clearly describes device characteristics and allows to compare different dialyzer performances without resorting to the technical data sheets. Therefore, the presence of the DIC on every device facilitates information retrieval on the dialyzer, its intended use, and can facilitate matching the dialysis modality to correct dialyzers achieving a personalized renal replacement therapy. The standard filter characteristics codification by the DIC may further optimize correct extracorporeal blood purification prescriptions and the use of equivalent filters from different providers avoiding treatment inefficiency, clinical complications, and improving patient safety.

show abstract

“…According to Anis et al [ 49 ], membrane fouling forms the third-largest research area in MF with over 600 papers published in the course of 10 years to the date of their work, and such a topic is still receiving attention thanks to the newest trends involving fouling mitigation through membrane modification and innovative investigation techniques aimed at studying the fouling phenomena at a microscopic level [ 50 , 51 , 52 , 53 ]. Indeed, the effects governing flux decline generally occur at quite small time and spatial scales, the latter corresponding to the dimension of the pores; studying fouling in micro-sized geometries would therefore allow achieving key insights regarding the interactions between foulants and membrane surface.…”

Section: Introductionmentioning

confidence: 99%

Membrane Fouling Phenomena in Microfluidic Systems: From Technical Challenges to Scientific Opportunities

2021

View full text Add to dashboard Cite

The almost ubiquitous, though undesired, deposition and accumulation of suspended/dissolved matter on solid surfaces, known as fouling, represents a crucial issue strongly affecting the efficiency and sustainability of micro-scale reactors. Fouling becomes even more detrimental for all the applications that require the use of membrane separation units. As a matter of fact, membrane technology is a key route towards process intensification, having the potential to replace conventional separation procedures, with significant energy savings and reduced environmental impact, in a broad range of applications, from water purification to food and pharmaceutical industries. Despite all the research efforts so far, fouling still represents an unsolved problem. The complex interplay of physical and chemical mechanisms governing its evolution is indeed yet to be fully unraveled and the role played by foulants’ properties or operating conditions is an area of active research where microfluidics can play a fundamental role. The aim of this review is to explore fouling through microfluidic systems, assessing the fundamental interactions involved and how microfluidics enables the comprehension of the mechanisms characterizing the process. The main mathematical models describing the fouling stages will also be reviewed and their limitations discussed. Finally, the principal dynamic investigation techniques in which microfluidics represents a key tool will be discussed, analyzing their employment to study fouling.

show abstract

A critical review of recent advances in hemodialysis membranes hemocompatibility and guidelines for future development

Cited by 99 publications

References 144 publications

Case studies of clinical hemodialysis membranes: influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers

Case studies of clinical hemodialysis membranes: influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers

The Dialyzer Identification Code (DIC): A filter characteristics codification for dialyzer choice in renal replacement therapy

Membrane Fouling Phenomena in Microfluidic Systems: From Technical Challenges to Scientific Opportunities

Contact Info

Product

Resources

About