A critical review of synthesis procedures, applications and future potential of nanoemulsions

Naseema, A; Kovooru, Lohitesh; Behera, Alok Kumar; Kumar, K. Siva; Srivastava, Priyanka

doi:10.1016/j.cis.2020.102318

Cited by 100 publications

(60 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Figure 1 highlights the presence of three different regions corresponding to homogeneous dispersions (dark blue region) and non-homogeneous dispersions, characterized by phase separation phenomena (light blue zone). Inside the light blue zone, only for some formulations, the sonication leads to the formation of monophasic dispersions (blue zone) [28][29][30]. To optimize the monophasic emulsions as a suitable drug delivery system (NEs), all samples in the dark blue region were sonicated for 20 min at 50 • C. The best formulation in terms of hydrodynamic diameter, ζ-potential, and PDI was selected and observed by TEM.…”

Section: Ne Design and Characterizationmentioning

confidence: 99%

Resveratrol-Loaded Nanoemulsions: In Vitro Activity on Human T24 Bladder Cancer Cells

et al. 2021

View full text Add to dashboard Cite

The chemopreventive potential of Resveratrol (RV) against bladder cancer and its mechanism of action have been widely demonstrated. The physicochemical properties of RV, particularly its high reactivity and low solubility in aqueous phase, have been limiting factors for its bioavailability and in vivo efficacy. In order to overcome these limitations, its inclusion in drug delivery systems needs to be taken into account. In particular, oil-in-water (O/W) nanoemulsions (NEs) have been considered ideal candidates for RV encapsulation. Since surfactant and oil composition can strongly influence NE features and their application field, a ternary phase diagram was constructed and evaluated to select a suitable surfactant/oil/water ratio. The selected sample was deeply characterized in terms of physical chemical features, stability, release capability and cytotoxic activity. Results showed a significant decrease in cell viability after the incubation of bladder T24 cancer cells with RV-loaded NEs, compared to free RV. The selected NE formulation was able to preserve and improve RV cytotoxic activity by a more rapid drug uptake into the cells. O/W NEs represent an effective approach to improve RV bioavailability.

show abstract

Section: Ne Design and Characterizationmentioning

confidence: 99%

Resveratrol-Loaded Nanoemulsions: In Vitro Activity on Human T24 Bladder Cancer Cells

et al. 2021

View full text Add to dashboard Cite

show abstract

“…43 This kind of nanocarriers are formulated by water, oil, and surfactants/biopolymers in several types of single A c c e p t e d M a n u s c r i p t water-in-oil (W/O) or oil-in-water (O/W) nanoemulsions, double water-in-oil-in-water (W/O/W) or oilin-water-in-oil (O/W/O) nanoemulsions, Pickering nanoemulsions formed by biopolymer nanoparticles, and structural nanoemulsions covered by one or two layers of biopolymer materials. 42 A detailed information pertained to different nanoemulsion structures can be found in different studies (Shaddel et al 44 , Salvia-Trujillo et al 45 , Naseema et al 46 , Nejatian et al 47 ). Oil-in-water nanoemulsions are particularly appropriate for nanoencapsulation and carrying lipophilic vitamins due to their reliable physicochemical stability along with acceptable oral bioavailability.…”

Section: Nanoemulsionmentioning

confidence: 99%

Encapsulation of Vitamins Using Nanoliposome: Recent Advances and Perspectives

et al. 2021

View full text Add to dashboard Cite

Nowadays the importance of vitamins is clear for everyone. However, many patients are suffering from insufficient intake of vitamins. Incomplete intake of different vitamins from food sources due to their destruction during food processing or decrease in their bioavailability when mixing with other food materials, are factors resulting in vitamin deficiency in the body. Therefore, various lipid based nanocarriers such as nanoliposomes were developed to increase the bioavailability of bioactive compounds. Since the function of nanoliposomes containing vitamins on the body has a direct relationship with the quality of produced nanoliposomes, this review study was planned to investigate the several aspects of liposomal characteristics such as size, polydispersity index, zeta potential, and encapsulation efficiency on the quality of synthesized vitamin-loaded nanoliposomes.

show abstract

“…Figure 2 highlights the presence of three different regions corresponding to homogeneous dispersions (black region) and non-homogeneous dispersions, characterized by phase separation phenomena (light grey zone). Moreover, sonication leads to the formation of monophasic dispersions for some formulations in the non-homogeneous region (dark grey zone) [26,42,46].…”

Section: Ne Design and Characterizationmentioning

confidence: 99%

“…In order to obtain better biopharmaceutical properties, and reduce doses and side effects, as well as to preserve the volatile compounds that show the main antimicrobial activity, a great effort is needed to develop suitable delivery systems. Recently, nanotechnology has had a significant impact in the field of medicine, food, cosmetics, skincare, agriculture, and broiler houses [26], and supported their improvement. Scientists have developed innovative drug delivery systems characterized by high physical-chemical stability, easy and reliable production, useful features, and low cost.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsions of Satureja montana Essential Oil: Antimicrobial and Antibiofilm Activity against Avian Escherichia coli Strains

et al. 2021

View full text Add to dashboard Cite

Satureja montana essential oil (SEO) presents a wide range of biological activities due to its high content of active phytochemicals. In order to improve the essential oil’s (EO) properties, oil in water nanoemulsions (NEs) composed of SEO and Tween-80 were prepared, characterized, and their antimicrobial and antibiofilm properties assayed against Escherichia coli strains isolated from healthy chicken. Since surfactant and oil composition can strongly influence NE features and their application field, a ternary phase diagram was constructed and evaluated to select a suitable surfactant/oil/water ratio. Minimal inhibitory concentration and minimal bactericidal concentration of NEs, evaluated by the microdilution method, showed that the SEO NE formulation exhibited higher inhibitory effects against planktonic E. coli than SEO alone. The quantification of biofilm production in the presence of NEs, assessed by crystal violet staining and scanning electron microscopy, evidenced that sub-MIC concentrations of SEO NEs enable an efficient reduction of biofilm production by the strong producer strains. The optimized nanoemulsion formulation could ensure food safety quality, and counteract the antibiotic resistance of poultry associated E. coli, if applied/aerosolized in poultry farms.

show abstract

A critical review of synthesis procedures, applications and future potential of nanoemulsions

Cited by 100 publications

References 100 publications

Resveratrol-Loaded Nanoemulsions: In Vitro Activity on Human T24 Bladder Cancer Cells

Resveratrol-Loaded Nanoemulsions: In Vitro Activity on Human T24 Bladder Cancer Cells

Encapsulation of Vitamins Using Nanoliposome: Recent Advances and Perspectives

Nanoemulsions of Satureja montana Essential Oil: Antimicrobial and Antibiofilm Activity against Avian Escherichia coli Strains

Contact Info

Product

Resources

About