A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu)

Williams, Lawrence A. D.; Rösner, Harald; Levy, Hannah; Barton, E N

doi:10.1590/s0043-31442007000100004

Cited by 43 publications

(27 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ariza et al (2007) examined the effects of coumarin on the CNS, and demonstrated possible sedative; anxiolytic (GABAergic and serotonergic/noradrenergic mechanisms); anticonvulsant (voltage-dependent sodium channels mechanism); and antidepressant effects (inhibition of monoamine oxidase) (Chen et al, 2005).With regard to flavonoids, Youdim et al (2004) demonstrated the ability of these compounds to cross the blood-brain barrier and reach the CNS unchanged, which play an important role in the regulation of anxiety and epilepsy (mediated by GABA). Studies involving dibenzyl trisulfide (DTS) isolated from Petiveria alliacea have demonstrated hyper-phosphorylation of growth factor induced MAPKinases (erk 1 and erk 2) phosphorylation, which is critical for the improvement of long-term memory, and neuronal growth (Williams et al, 2007). Thus, the mnemonic effect induced by the Petiveria alliacea extract may be related to DTS acting via the MAPkinase pathway.…”

Section: Discussionmentioning

confidence: 99%

Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Andrade

Melo

Dias

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Andrade

Melo

Dias

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

“…Several reports describe the anti-proliferative and cytotoxic activity of DTS on a wide range of cancer cell lines (29,30 DTS also induced changes in the cytoskeleton proteins and influenced the cell proliferation machinery. The relation between the activities exerted by the fractions on the cytoskeleton and on the expression of HSPs needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

A fraction from Petiveria alliacea induces apoptosis via a mitochondria-dependent pathway and regulates HSP70 expression

et al. 2009

View full text Add to dashboard Cite

contributed equally to this work. AbstractObjective. To evaluate the biological activity of Petiveria alliacea extracts on tumoral cells in vitro. Materials and methods. P.alliacea fractions prepared by a bioguided purification protocol were characterized by their biological activities on two human tumoral cell lines. Morphological changes, cell viability, mitochondrial membrane depolarization, nuclear staining and activity on HSP70 were analyzed. Results. The present study demonstrates that P.alliacea fractions can induce apoptosis in a mitochondria-dependent pathway and down regulate HSP70 expression in vitro. The possible compounds present in P.alliacea responsible for the described biological activities were identified by dereplication methods. Conclusion. The present study provides new knowledge on the antitumoral properties of the plant species P. alliacea described in several ethnobotanical studies.Key words: apoptosis; cancer; heat shock proteins; Petiveria alliacea. ResumenUna fracción de Petiveria alliacea induce apoptosis dependiente de la mitocondria y regula la expresión de la proteína HSP70. Objetivo. Evaluar la actividad biológica in vitro de extractos de Petiveria alliacea utilizando líneas celulares tumorales. Materiales y métodos. Las fracciones de P.alliacea fueron preparadas mediante un protocolo de purificación biodirigido. La actividad biológica fue caracterizada utilizando dos líneas celulares tumorales de origen humano, donde se analizaron los cambios morfológicos, la viabilidad celular, la actividad sobre la membrana mitocondrial y la fragmentación nuclear. Asimismo se evaluó la actividad de las fracciones sobre la expresión de la proteína HSP70. Resultados. El presente estudio muestra que las fracciones de P.alliacea inducen muerte celular por apoptosis dependiente de la mitocondria y además regulan negativamente la expresión de la proteína HSP70. Los compuestos que posiblemente son responsables de la actividad biológica presente en las fracciones de P.alliacea fueron identificados por dereplicación. Conclusión. El presente estudio contribuye a explicar en parte las propiedades antitumorales de la planta P.alliacea descritas en diversos escritos etnobotánicos.

show abstract

“…A substance found in this species, dibenzyl trisulphide, exhibits antitumor and immunomodulatory activities [123]. The extract displayed several mechanisms of action that may explain its antitumor activity, such as cell cycle arrest in G2 phase, induction of cytoskeletal reorganization and DNA fragmentation [124].…”

Section: Survey Of the Current Components Of The Zombie Poison Andmentioning

confidence: 99%

Natural Products from Ethnodirected Studies: Revisiting the Ethnobiology of the Zombie Poison

Albuquerque

Melo

Medeiros

et al. 2012

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Wade Davis's study of Haitian “zombification” in the 1980s was a landmark in ethnobiological research. His research was an attempt to trace the origins of reports of “undead” Haitians, focusing on the preparation of the zombification poison. Starting with this influential ethnopharmacological research, this study examines advances in the pharmacology of natural products, focusing especially on those of animal-derived products. Ethnopharmacological, pharmacological, and chemical aspects are considered. We also update information on the animal species that reportedly constitute the zombie poison. Several components of the zombie powder are not unique to Haiti and are used as remedies in traditional medicine worldwide. This paper emphasizes the medicinal potential of products from zootherapy. These biological products are promising sources for the development of new drugs.

show abstract

A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu)

Cited by 43 publications

References 21 publications

Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

A fraction from Petiveria alliacea induces apoptosis via a mitochondria-dependent pathway and regulates HSP70 expression

Natural Products from Ethnodirected Studies: Revisiting the Ethnobiology of the Zombie Poison

Contact Info

Product

Resources

About