A Critical Review on the Nutritional and Medicinal Profiles of Garlic’s (
            <i>Allium sativum</i>
            L.) Bioactive Compounds

Ozma, Mahdi Asghari; Abbasi, Amin; Rezaee, Mohammad Ahangarzadeh; Hosseini, Hedayat; Hosseinzadeh, Negin; Sabahi, Sahar; Noori, Seyyed Mohammad Ali; Sepordeh, Sama; Khodadadi, Ehsaneh; Lahouty, Masoud; Kafil, Hossein Samadi

doi:10.1080/87559129.2022.2100417

Cited by 28 publications

(11 citation statements)

References 218 publications

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“…The enzyme alliinase breakdown alliin to create thiosulfinates like allicin after the garlic has undergone processing operations like chopping, chewing or crushing, or any other operations that disrupt the cell membrane. Allicin and other thiosulfinates breakdowns into DAS, diallyl trisulfide (DAT), DADS, dithiins, and ajoene very instantaneously while simultaneously γ-glutamyl-cysteine is converted to SAC by a different mechanism ( 18 ). Thiosulfinates, especially alliin is the most common precursor responsible for garlic’s flavor and these sulfur compounds are also responsible for garlic’s well-known therapeutic properties ( 19 ).…”

Section: Chemical Changes In Garlic After Processingmentioning

confidence: 99%

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Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An updated review

et al. 2023

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Garlic (Allium sativum) is an edible tuber belonging to the family Liliaceae. It has been used since ancient times as a spice to enhance the sensory characteristics of food and as a household remedy for the treatment of a variety of ailments. Garlic has been studied for its medicinal and therapeutic effects in the treatment of various human diseases for a long time. Health benefits associated with the consumption of garlic are attributed to the various sulfur compounds present in it such as allicin, ajoene, vinyl-dithiin, and other volatile organosulfur compounds which are all metabolized from alliin. Several researches in the literature have shown evidence that garlic exhibits antioxidant, antiviral, anti-microbial, anti-fungal, antihypertensive, anti-anemic, anti-hyperlipidemic, anticarcinogenic, antiaggregant, and immunomodulatory properties. The present review identifies and discusses the various health benefits associated with the consumption of garlic, its essential oil, and bioactive constituents, along with exploring the various snack-food products developed by incorporating garlic.

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Section: Chemical Changes In Garlic After Processingmentioning

confidence: 99%

“…The enzyme alliinase is released when tissues are crushed, chewing that converts cytosolic cysteine sulfoxides (alliin) into thiosulfinates ( Figure 7 ). These substances are smelly, volatile and reactive ( 18 , 116 ).…”

Section: Garlic Essential Oils: Their Composition and Propertiesmentioning

confidence: 99%

Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An updated review

et al. 2023

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“…and cannabis ( 283 , 284 ). Allicin, diallyl disulfide, propyl thiosulfinate oxide, allyl methyl thiosulfate, etc., are commonly found sulfur compounds in plants ( 285 , 286 ). They have been shown to have high antimicrobial, antioxidant, and anti-aging properties in multiple experiments ( 287 , 288 ).…”

Section: Methodsmentioning

confidence: 99%

Botanicals: A promising approach for controlling cecal coccidiosis in poultry

Saeed

Alkheraije

2023

Front. Vet. Sci.

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Avian species have long struggled with the problem of coccidiosis, a disease that affects various parts of the intestine, including the anterior gut, midgut, and hindgut. Among different types of coccidiosis, cecal coccidiosis is particularly dangerous to avian species. Chickens and turkeys are commercial flocks; thus, their parasites have remained critical due to their economic importance. High rates of mortality and morbidity are observed in both chickens and turkeys due to cecal coccidiosis. Coccidiostats and coccidiocidal chemicals have traditionally been added to feed and water to control coccidiosis. However, after the EU banned their use because of issues of resistance and public health, alternative methods are being explored. Vaccines are also being used, but their efficacy and cost-effectiveness remain as challenges. Researchers are attempting to find alternatives, and among the alternatives, botanicals are a promising choice. Botanicals contain multiple active compounds such as phenolics, saponins, terpenes, sulfur compounds, etc., which can kill sporozoites and oocysts and stop the replication of Eimeria. These botanicals are primarily used as anticoccidials due to their antioxidant and immunomodulatory activities. Because of the medicinal properties of botanicals, some commercial products have also been developed. However, further research is needed to confirm their pharmacological effects, mechanisms of action, and methods of concentrated preparation. In this review, an attempt has been made to summarize the plants that have the potential to act as anticoccidials and to explain the mode of action of different compounds found within them.

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“…In the past decade, the clinical isolation rate of K. pneumoniae has been rising, and in most countries, it has become the second most prevalent clinically isolated Gram-negative bacilli after E. coli [48]. The emergence of carbapenem-resistant K. pneumoniae causes a complicated problem for public health due to the lack of effective therapeutic options for the therapy of such infections [49,50]. K. pneumoniae carbapenemase (KPC) is one of the most significant carbapenemases found in K. pneumoniae, whose acquisition has contributed to resistance to all β-lactams in this microorganism and the therapy of infections caused by them has faced many problems [51].…”

Section: N Treatment Of Pdr a Baumanniimentioning

confidence: 99%

Antibiotic therapy for pan-drug-resistant infections

et al. 2022

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Antibiotic resistance occurs when microorganisms resist the drugs used against the infection caused by them and neutralize their effects over time using various mechanisms. These mechanisms include preventing drug absorption, changing drug targets, drug inactivating, and using efflux pumps, which ultimately cause drug resistance, which is named pan-drug-resistant (PDR) infection if it is resistant to all antimicrobial agents. This type of drug resistance causes many problems in society and faces the health system with difficulties; therefore their treatment is crucial and encourages doctors to develop new drugs to treat them. PDR Gram-negative bacteria, including Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli are among the most significant resistant bacteria to many antimicrobial agents, and only a limited range of antibiotics, especially synergistically are effective on them. For the therapy of PDR A. baumannii, tigecycline in com-bination with colestimethate, imipenem, amikacin, and ampicillin-sulbactam are the most effective treatments. The utilization of β-lactamase inhibitors such as ceftolozane-tazobactam, ceftazidime-avibactam, or imipenem-cilastatin-relebactam has the most efficacy against PDR P. aeruginosa. The PDR K. pneumoniae has been treated in the last decades with tigecycline and colistin, but currently, nitrofurantoin, fosfomycin, and pivmecillinam seem to be the most effective agent for the therapy of PDR E. coli. While these drugs impressively struggle with PDR pathogens, due to the daily increase in antibiotic resistance in microorganisms worldwide, there is still an urgent need for the expansion of novel medicines and methods of combating resistance.

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A Critical Review on the Nutritional and Medicinal Profiles of Garlic’s ( Allium sativum L.) Bioactive Compounds

Cited by 28 publications

References 218 publications

Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An updated review

Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An updated review

Botanicals: A promising approach for controlling cecal coccidiosis in poultry

Antibiotic therapy for pan-drug-resistant infections

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