A critical review on the relationship of herbal medicine, Akkermansia muciniphila, and human health

Bu, Fan; Zhang, Shuhui; Duan, Zhenglan; Ding, Yang; Chen, Tuo; Wang, Rong; Feng, Zeyu; Shi, Guo‐Ping; Zhou, Jin‐Yong; Chen, Yugen

doi:10.1016/j.biopha.2020.110352

Cited by 23 publications

(9 citation statements)

References 74 publications

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“…A healthy gastrointestinal tract can be characterized by the predominant residency of obligate anaerobes like Firmicutes and Bacteroidetes [ 41 ]. Major studies have upheld that low F/B ratio denotes healthy gut condition [ 42 ] while increased F/B ratio is associated with obesity [ 43 ]. A significantly low F/B ratio was observed in Sham group whereas a significantly high F/B ratio was observed in the NC group.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, the role of A. muciniphila in obesity [ 45 ] and diabetes [ 46 ] has been reported. A. muciniphila was known as a promising probiotic which promote the intestinal health and showing negative correlation with the occurrence of diabetes [ 43 ]. On top of that, a collective of studies have reported that A. muciniphila plays a crucial role in keeping the intestinal barrier intact, maintaining the permeability of intestinal mucosa and preventing the occurrence of inflammatory response in the host [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Trifolium pratense ethanolic extract alters the gut microbiota composition and regulates serum lipid profile in the ovariectomized rats

Quah

Park

Lee

et al. 2022

BMC Complement Med Ther

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Background Trifolium pratense (red clover) ethanolic extract (TPEE) has been used as a popular over-the-counter remedy for the management of menopausal symptoms. Prolonged consumption of herbal extract has been shown to regulate the composition of gut microbiota. This study was designed to elucidate the influence of TPEE on the gut microbiota composition in the ovariectomized (OVX) rats. Methods OVX rats were treated with TPEE at 125, 250, 500 mg/kg/day, or controls (pomegranate extract, 500 mg/kg/day; estradiol, 25 μg/kg/day) for 12 weeks. Gut microbiota analysis was conducted by extracting the microbial DNA from fecal samples and microbiome taxonomic profiling was carried out by using next-generation sequencing. The levels of serum biomarkers were analyzed using enzyme-linked immunosorbent assay (ELISA) kit. The prediction of functional biomarker of microbiota was performed using PICRUSt to investigate the potential pathways associated with gut health and serum lipid profile regulation. To study the correlation between gut microbiota composition and serum lipid levels, Spearman’s correlation coefficients were defined and analyzed. Additionally, gas chromatography–mass spectrometry analysis was conducted to uncover additional physiologically active ingredients. Results TPEE-treated OVX rats showed significant reduction in serum triglycerides (TG), total cholesterols (TCHOL), and LDL/VLDL levels but increase in HDL level. The alteration in the pathways involve in metabolism was the most common among the other KEGG categories. Particularly, TPEE also significantly reduced the relative abundance of sequences read associated with inflammatory bowel disease (IBD) and the peroxisome proliferator-activated receptor (PPAR) signalling pathway. TPEE intervention was seen to reduce the Firmicutes to Bacteroidetes (F/B) ratio in the OVX rats, denoting a reduction in microbial dysbiosis in the OVX rats. Correlation analysis at the phylum level revealed that Bacteriodetes and Proteobacteria were strongly correlated with serum TG, TCHOL and HDL levels. At the species level, Bifidobacterium pseudolongum group was seen to positively correlate with serum HDL level and negatively correlated with serum AST, ALT, LDL/VLDL, TCHOL, and TG levels. Conclusions TPEE treatment showed therapeutic benefits by improving the intestinal microbiota composition which strongly correlated with the serum lipid and cholesterol levels in the OVX rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trifolium pratense ethanolic extract alters the gut microbiota composition and regulates serum lipid profile in the ovariectomized rats

Quah

Park

Lee

et al. 2022

BMC Complement Med Ther

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“…Our previous studies demonstrated that FMT or probiotic therapy was identified as novel interventions for gastrointestinal disease, which is attributed to the normalization of gut microbial dysbiosis ( Chen et al., 2018 ; Bu et al., 2020 ). The present study indicated that A. muciniphila supplementation increased the relative abundance of Ruminiclostridium in recipient mice.…”

Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis

Chen

Wang

Duan

et al. 2021

Front. Cell. Infect. Microbiol.

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Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in microbiota composition, disruption of colonic mucus, and aggravation of colitis. In addition, the abundance of Akkermansia muciniphila was significantly decreased in mice under CRS and UC patients with depression, and positively associated with the expression of MUC2. After antibiotic treatment, the recipient mice colonized with CRS microbiota showed barrier defects and severe colitis. Administration of Akkermansia muciniphila was found to restore colonic mucus and modify the gut microbiota. We confirm that CRS-mediated gut microbiota dysbiosis results in colonic mucosal barrier damage and aggravation of colitis. Our results suggest that A. muciniphila is expected to be a potential probiotic to protect and treat colonic mucus that is involved in IBD with psychological disorders.

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“…The observed metabolic effects of prebiotics have previously been linked with changes in the microbiota and are often associated with an increased abundancy of Akkermansia muciniphila , a commensal bacterium with proven health-promoting properties [ 19 , 24 , 25 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Moreover, several herbal-based dietary intervention studies have been shown to increase the abundance of Akkermansia muciniphila [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Rhubarb Supplementation Prevents Diet-Induced Obesity and Diabetes in Association with Increased Akkermansia muciniphila in Mice

et al. 2020

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Obesity and obesity-related disorders, such as type 2 diabetes have been progressively increasing worldwide and treatments have failed to counteract their progression. Growing evidence have demonstrated that gut microbiota is associated with the incidence of these pathologies. Hence, the identification of new nutritional compounds, able to improve health through a modulation of gut microbiota, is gaining interest. In this context, the aim of this study was to investigate the gut-driving effects of rhubarb extract in a context of diet-induced obesity and diabetes. Eight weeks old C57BL6/J male mice were fed a control diet (CTRL), a high fat and high sucrose diet (HFHS) or a HFHS diet supplemented with 0.3% (g/g) of rhubarb extract for eight weeks. Rhubarb supplementation fully prevented HFHS-induced obesity, diabetes, visceral adiposity, adipose tissue inflammation and liver triglyceride accumulation, without any modification in food intake. By combining sequencing and qPCR methods, we found that all these effects were associated with a blooming of Akkermansia muciniphila, which is strongly correlated with increased expression of Reg3γ in the colon. Our data showed that rhubarb supplementation is sufficient to protect against metabolic disorders induced by a diet rich in lipid and carbohydrates in association with a reciprocal interaction between Akkermansia muciniphila and Reg3γ.

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A critical review on the relationship of herbal medicine, Akkermansia muciniphila, and human health

Cited by 23 publications

References 74 publications

Trifolium pratense ethanolic extract alters the gut microbiota composition and regulates serum lipid profile in the ovariectomized rats

Trifolium pratense ethanolic extract alters the gut microbiota composition and regulates serum lipid profile in the ovariectomized rats

Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis

Rhubarb Supplementation Prevents Diet-Induced Obesity and Diabetes in Association with Increased Akkermansia muciniphila in Mice

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