A critical review on therapeutic corroboration of myricetin

Pujari, Neelkanth M.; Mishra, Anuradha

doi:10.5958/0975-6892.2021.00002.2

Cited by 2 publications

(2 citation statements)

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“…Several review articles on the pharmacology of MYR have been published in the past few years. 4,5,8,[11][12][13]29,40,45,52,53,56,81,83,[86][87][88][89][90]…”

Section: Pharmacological Significancementioning

confidence: 99%

Antiviral and Possible Prophylactic Significance of Myricetin for COVID-19

Agrawal¹,

Agrawal²,

Blunden

2023

Natural Product Communications

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Myricetin (3,5,7,3′,4′,5′ -hexahydroxyflavone), a common dietary flavonoid, has been reported for its roles in improving health due to various pharmacological activities, such as antioxidant, antimicrobial, anti-inflammatory, analgesic, antitumor, hepatoprotective, and antidiabetic. Myricetin has also been shown to have a broad spectrum of antiviral effects against a variety of viruses including Rauscher murine leukemia virus (RLV), human immunodeficiency virus (HIV), Coxsackie virus, Ebolavirus, Zika virus, herpes simplex virus (HSV-1 and HSV-2), dengue virus, murine norovirus, infectious bronchitis virus, African swine fever virus, and both DNA polymerase α and DNA polymerase I. Intensive research suggests that the remarkable potential of myricetin in promoting either the prevention or overcoming of SARS-CoV-2 infection is due to the wide range of its effects on SARS-COV-2 proteases, including modulation of inflammatory processes and immune responses. In silico and in vitro studies demonstrated that myricetin can effectively interfere at various stages of viral infection, including the coronavirus entry and replication cycle due to its high-binding affinity with S-protein, ACE2 receptor, PLpro, Mpro, RdRp, exonuclease, and endoribonuclease. Based on the findings discussed in this review, myricetin, its glycosides, and dihydromyricetin, can be considered as multi-targeted agents having beneficial effects in combatting COVID-19.

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“…Several review articles on the pharmacology of MYR have been published in the past few years. 4,5,8,[11][12][13]29,40,45,52,53,56,81,83,[86][87][88][89][90]…”

Section: Pharmacological Significancementioning

confidence: 99%

Antiviral and Possible Prophylactic Significance of Myricetin for COVID-19

Agrawal¹,

Agrawal²,

Blunden

2023

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…Anti‐leukemia activity of myricetin was reported by interfering with biosynthetic pathway of purine nucleotides by inhibiting inosine 5'‐monophosphate dehydrogenase (hIMPDH) 1/2 catalytic activity (Mondal et al., 2016 ). Researchers determined the anticancer role of myricetin against human MCF‐7 cells by applying different doses at (0–80 µM) for 12, 24 and 48 hr (Pujari & Mishra, 2021 ). Multiple cell pathways were involved with consequent cell viability reduction, apoptosis induction, suppression of protein expression of p21‐activated kinase 1 and phosphorylated extracellular MAPK and activation of Bax protein expression, GSK3β, promotion of caspase‐3 activity, and suppression of β‐catenin and cyclin D1, respectively (Jiao & Zhang, 2016 ).…”

Section: Health Propertiesmentioning

confidence: 99%