2013
DOI: 10.1371/journal.pbio.1001684
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A Critical Role for the Hippocampus in the Valuation of Imagined Outcomes

Abstract: Converging evidence from neuroimaging and clinical data demonstrates the important involvement of the hippocampus in finding the motivation to pursue goals that we need to imagine because they are not within sight.

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Cited by 108 publications
(107 citation statements)
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References 55 publications
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“…Perhaps surprisingly, the MFG cluster was not activated by the contrast between patient and impulsive choice, contrary to observations in some previous studies (5,26). This result might come from a limitation of our design.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…Perhaps surprisingly, the MFG cluster was not activated by the contrast between patient and impulsive choice, contrary to observations in some previous studies (5,26). This result might come from a limitation of our design.…”
Section: Discussioncontrasting
confidence: 99%
“…In humans, the capacity to resist the temptation of immediate rewards at a young age is a key predictor of long-term life outcomes, as was shown with the famous marshmallow test (2). At the neural level, this capacity for self-control is associated with the recruitment of regions in the lateral prefrontal cortex (LPFC) (3)(4)(5). Conversely, LPFC inhibition through transcranial magnetic stimulation (TMS) was shown to enhance the propensity to make impulsive choices, i.e., to favor immediate rewards (6,7).…”
mentioning
confidence: 99%
“…These observations have been supported by some evidence from patients with hippocampal damage (77) or atrophy following Alzheimer’s disease (76) showing that temporal discounting is not attenuated by situations requiring episodic future thinking in these populations (see also [78] for similar findings in healthy older adults). However, another study of amnesic patients (79) provided seemingly contradictory results, i.e., patients showed attentuation of temporal discounting in a situation also thought to induce episodic future thinking.…”
Section: Functions Of Episodic Future Thinkingmentioning
confidence: 77%
“…Initial fMRI evidence pointed toward a role for the hippocampus in mediating effects of simulation on temporal discounting (6869; 76). These observations have been supported by some evidence from patients with hippocampal damage (77) or atrophy following Alzheimer’s disease (76) showing that temporal discounting is not attenuated by situations requiring episodic future thinking in these populations (see also [78] for similar findings in healthy older adults).…”
Section: Functions Of Episodic Future Thinkingmentioning
confidence: 99%
“…The ability to imagine fictitious or future events and choice situations that require imagining potential outcomes involves regions of the brain associated with memory, such as the hippocampus [21,42]. However, other anatomical correlates contribute to the prospective brain, such as the amygdala, which is more active when imagining positive future events relative to negative ones, suggesting a key role in mediating the optimism bias through the process of monitoring emotional salience [37].…”
Section: Introductionmentioning
confidence: 99%