A critical scoping review of external uses of comfrey (Symphytum spp.)

Frost, Rachael; MacPherson, Hugh; O’Meara, Susan

doi:10.1016/j.ctim.2013.09.009

Cited by 31 publications

(26 citation statements)

References 38 publications

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“…Cameron and Chrubasik [7] could not make valid conclusions on the effectiveness of topical herbal product from Sym phytum officinale (comfrey) based on one study. Frost et al 2013 included two other RCTs on comfrey in their systematic review [28]. They argued that comfrey might be beneficial for patients who suffer from OA.…”

Section: Discussionmentioning

confidence: 99%

Phytotherapy for osteoarthritis

et al. 2017

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Summary Background: In order to present recent findings on the effectiveness and safety of phytotherapy for treatment of osteoarthritis (OA) we summarized the two latest Cochrane reviews (Cameron & Chrubasik, 2013; Cameron & Chrubasik, 2014). One of them included oral and the other topical herbal treatment options as a treatment for OA. Methods: We conducted a thorough evaluation of the Cochrane reviews. We assessed methodological quality of the reviews and extracted evidence. Results: Meta-analyses found evidence for effects of the oral herbal products Boswellia serrata and only partially for avocado-soybean unsaponifiable (ASU). However, they included only a small number of primary studies. The systematic review on topical herbal treatments included fewer trials and did not include a meta-analysis. Discussion: Based on the qualitative syn?thesis Boswellia serrata can be applied in the treatment of OA. It is not clear if ASU can be recommended. No valid recommendation can be given for or against other herbal therapies due to a lack of randomized ?clinical trials in the field.

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Section: Discussionmentioning

confidence: 99%

Phytotherapy for osteoarthritis

et al. 2017

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“…officinalis root belongs to the family Boraginaceae and is widely used in Western herbal medicine practice. 8 It contains carotene, essential oils, vitamin B12, zinc and allantoin which are known to have a healing capacity. 9,10 S. officinalis contains pyrroloizidine alkaloids which are associated with hepatic disease under certain conditions.…”

Section: Introductionmentioning

confidence: 99%

Bone computed tomography mineral content evaluation in chickens: effects of substances in homeopathic concentration

Canello¹,

Gasparini

Luisetto³

et al. 2016

Homeopathy

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“…Die Wirksamkeit in diesen Indikationen wurde in einer Reihe klinischer Studien nachgewiesen (siehe Übersichten [6,9,11] …”

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“…Im Falle der Fibroblasten war für Allantoin in Konzentrationen bis 400 µg/ml kein Effekt sichtbar, während Diclofenac ab 50 µg/ml die Freisetzung reduzierte (▶ Abb. 5B).DiskussionIn einem kritischen Review von Studien zu Beinwell-Zubereitungen kommen Frost et al(6) zu dem Schluss, dass Wirksamkeit und Nutzen bei Verstauchungen, Rückenschmerzen, Schürfwunden und Osteoarthritis durch einzelne Studien belegt seien; sie weisen jedoch darauf hin, dass…”

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Beinwellsalbe

Casetti¹,

Wölfle²,

Seelinger³

et al. 2015

Z Phytother

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Zusammenfassung Eine Salbenzubereitung aus Beinwellkraut (Symphytum ? uplandicum Nyman) wurde in einer offenen, nicht-interventionellen Studie an 24 Patienten mit leichten Gelenkschmerzen nach Trauma in einer Universit?tsklinik getestet. Zweimal t?gliches Auftragen ?ber eine Woche f?hrte zu deut?licher Besserung des Schmerzindex von 1,2 auf 0,5, gleichzeitig verbesserte sich die Hydratation der oberen Hautschichten signifikant. Einer der wirksamkeitsbestimmenden Inhaltsstoffe des Beinwells, Allantoin, hatte in experimentellen Untersuchungen an Zellkulturen mit Keratinozyten und prim?ren Fibroblasten eine entz?ndungshemmende Wirkung. Sowohl Allantoin als auch die Vergleichssubstanz Diclofenac reduzierten die durch TNF-? oder simulierte solare Strahlung induzierte Freisetzung des proinflammatorischen Interleukins IL-6 mit effektiven Konzentrationen von ca. 50 ?g/ml. Allantoin war nicht zytotoxisch und beeintr?chtigte weder die Stoffwechselaktivit?t noch die Proliferationsrate der Hautzellen.

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A critical scoping review of external uses of comfrey (Symphytum spp.)

Cited by 31 publications

References 38 publications

Phytotherapy for osteoarthritis

Phytotherapy for osteoarthritis

Bone computed tomography mineral content evaluation in chickens: effects of substances in homeopathic concentration

Beinwellsalbe

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