“…In the large group of depressionswe would naturally distinguish our casesaccording to etiology, the symptom-complexthe courseof the diseaseand the results―.Alas, Meyer's hopes have remained unfulfilled in the subsequent eight decades. In fact the confusion worsened and Ascher (1952) commented: â€oe¿ There appearsto be a good deal of confusion in the literature, as well as in practice, about depressiveillnesswhich is a left-over from the era of descriptive psychiatry. Concepts of psycho genesis, endogeny,reactivity, neurosis,psychosisand others have been introduced to clarify the issue .…”