Background: The COVID-19 pandemic situation with the lockdown of public life caused serious changes in people's everyday practices. The study evaluates the differences between Slovenia and Italy in health-related everyday practices induced by the restrictive measures during first wave of the COVID-19 pandemic.Methods: The study examined changes through an online survey conducted in nine European countries from April 15-28, 2020. The survey included questions from a simple activity inventory questionnaire (SIMPAQ), the European Health Interview Survey, and some other questions. To compare changes between countries with low and high incidence of COVID-19 epidemic, we examine 956 valid responses from Italy (N=511; 50% males) and Slovenia (N=445; 26% males).Results: During the survey, there was a 4.7-fold higher incidence and 12.1-fold more deaths (per 100,000) in Italy than in Slovenia. Barring periods and measures were similar, the latter more stringent in Italy. We found more changes in Italy than in Slovenia: physical inactivity increased (Italy: +65% vs. Slovenia: +21%; p< 0.001), walking time decreased (Italy: -68% vs. Slovenia: -4.4%; p< 0.001); physical work increased by 38% in Slovenia (p< 0.001), and recreation time decreased by 37% in Italy (p< 0.001). Italians reported a decrease in quality of general health, fitness level, psychological well-being, and quality of life (p<0.001); Slovenians showed a decline in psychological well-being and quality of life (p<0.001) but generally had a higher concern for their own health (p=0.005). Changes in eating habits (meal size and consumption of unhealthy food), age and physical inactivity were positively correlated with increases in body mass, while changes in general well-being and concern for health were negatively correlated.Conclusion: The study highlights the implications of COVID-19 measures and epidemiological data and provides insight into the relationship between them and various lifestyle consequences of COVID-19 measures. These findings should be taken into consideration in the implementation of further measures to mitigate the COVI-19 pandemic.