A cross-linkable and resorbable PEDOT-based ink using a hyaluronic acid derivative as dopant for flexible bioelectronic devices

Abstract

A PEDOT:hyaluronic acid ink was printed on a PLGA film, then UV-crosslinked to design non soluble conductive patterns. The ink was fully resorbable within 2 months when immersed in water, paving the way towards transient bioelectronic devices.

Resorbable conductive materials for optimally interfacing medical devices with the living

“…Poly(pyrrole) (PPy) is a heterocyclic polymer that can be easily synthetized in different solvents (such as water) and polymerized via chemical or electrochemical routes of pyrrole oxidation ( Mao et al, 2018 ). Due to its high biocompatibility, ease of preparation, and good conductivity in physiological conditions, it has been widely used at the interface between bioelectronic systems and cells or tissues, for both recording and stimulation purposes ( Liu et al, 2023b ). Notably, PPy is a suitable substrate in the modulation of different cellular activities (such as cell attachment and proliferation) and possesses excellent biocompatibility in vivo ( Huang et al, 2014b ).…”

“…(A) Interpenetrating networks of scaffolding and conducting polymers : conducting polymer PEDOT is chemically synthetized in a solution of modified hyaluronic acid (HA) polymer. The PEDOT:HA ink can be further photo-cross-linked to achieve non-water soluble resorbable conductive hydrogels ( Leprince et al, 2023b ). Adapted with permission from Leprince et al (2023a) , Copyright 2023, Elsevier, and Leprince et al (2023b) , Copyright 2023, the Royal Society of Chemistry.…”

“…The PEDOT:HA ink can be further photo-cross-linked to achieve non-water soluble resorbable conductive hydrogels ( Leprince et al, 2023b ). Adapted with permission from Leprince et al (2023a) , Copyright 2023, Elsevier, and Leprince et al (2023b) , Copyright 2023, the Royal Society of Chemistry. (B) Extrusion printing : (i) a bioprintable conductive ink is obtained by mixing thiolated gelatin and defect-rich MoS 2 nano-assemblies.…”

“…The HA dopant was further functionalized to introduce alkene moieties that could photo-crosslink with a PEG-bis(thiol) linker to obtain a resorbable PEDOT:HA conductive ink. This ink was inkjetted on a flexible PLGA substrate in order to design a bioelectronic system that could resorb within 2 months in physiological conditions ( Leprince et al, 2023b ).…”

“…CP nanotubes (70–175 nm diameter) ( Abidian et al, 2008 ; Abidian et al, 2009 ; Abidian et al, 2010 ) and microstructures ( Antensteiner et al, 2017a ; Khorrami et al, 2017 ) advantageously enhanced the surface roughness of the CP films and improved the cellular response of neurons for chronic stimulation and recording. Our group recently developed a resorbable PEDOT:HA ink that can be inkjet-printed and UV-cross-linked on molybdenum tracks patterned onto a flexible PLGA substrate, to serve as a transient recording device of visual stimuli ( Leprince et al, 2023b ). The conductivity of the tracks and signal recording was maintained for approximately 4 months of implantation on rat cortex, correlated with the system resorption in vivo .…”