A cross‐national study of depression in preclinical dementia: A COSMIC collaboration study

Abstract

Introduction: Depression commonly accompanies Alzheimer's disease, but the nature of this association remains uncertain. Methods: Longitudinal data from the COSMIC consortium were harmonized for eight population-based cohorts from four continents. Incident dementia was diagnosed in

A Novel Score for Predicting Alzheimer’s Disease Risk from Late Life Psychopathological and Health Risk Factors

“…However, we assessed clinically significant depression and anxiety, excluding mild/ subsyndromal symptoms, and we think that the higher specificity in diagnosis of depression and anxiety could support the hypothesis of the real risk interpretation, as opposed to prodromal symptoms of emotional dysregulation described as part of the Mild Behavioral Impairment construct [ 57 ]. This is currently a controversial question and further studies are needed, because the few studies that have explored longitudinal trajectories of depression in preclinical phase of dementia [ 58 , 59 ] suggest that depression is more likely to be a prodromal symptom and related to dementia-related brain changes.…”

The Mediating Effects of Information and Communication Technology Use and Social Activity on the Relationship between Depression and Cognitive Function in Older Koreans

“…Meanwhile, contrary to the accumulation of studies that identified relationship between depression and cognitive function [5,[7][8][9], and factors influencing depression and cognitive function [6,12,16], there were very few studies identifying the mediating effect of ICT use and social activity between depression and cognitive function. Accordingly, this study attempted to explore the mediating effects to confirm ICT use and social activity act as mediators for cognitive decline caused by depression in older Koreans, aiming to provide useful information and basic data for the improvement of cognitive enhancement program.…”

“…In addition, more severe symptoms of depression could raise the risk of dementia [7], leading to an increased risk of all-cause dementia including Alzheimer's disease [8]. In longitudinal studies, the incidence of depression became higher in the pre-clinical phase of dementia [9] and depression increased cognitive impairment and dementia in the long term [7,10]. Contrary to these studies, there was also a study that showed that depression in the older adults was related to cognitive decline but was not related to dementia-related pathology [11].…”

The default mode network, depression and Alzheimer’s disease

“…Lagged effects were found to show that depressive symptoms preceded future reports of self-reports of 10-year decline in memory (Yates, 2020). A multinational study from the COSMIC consortium showed an increase in the incidence of depression as the time to the diagnosis of dementia decreased, even though the rates of depression varied across different studies (Carles et al, 2020), arguing for depression as a prodrome of dementia.…”

“…It is well recognized that only a proportion of aMCI progresses to AD dementia (Petersen et al, 2009). The lack of biomarkers also raises the possibility that some of the depression group, especially those with aMCI, also had AD pathology, given the reports of depression as a prodromal feature of dementia (Carles et al, 2020). It may therefore be more appropriate not to equate aMCI with AD in such a study.…”