A cross-sectional analysis of the association between testosterone and biopsy-proven non-alcoholic fatty liver disease in men with obesity

Herdt, Carlien De; Block, Christophe De; Francque, Sven; Verrijken, An; Dessel, Kristof Van; Gaal, Luc Van; Cauwenberghe, Jolijn Van; Dirinck, Eveline

doi:10.1007/s12020-022-03245-y

Cited by 2 publications

(2 citation statements)

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“…38 Some studies in men measuring total testosterone in biopsy-proven NAFLD have not found an inverse relationship though these sample sizes are generally less than 200 patients. 39,40 Our study showed a positive association between total testosterone and NAFLD in premenopausal women, as was noted in other studies, 41 but our study did not demonstrate an association between total testosterone and NAFLD in the postmenopausal TA B L E 3 Multivariable odds ratios of risk factors for NAFLD using Hepatic Steatosis Index according to sex hormone levels in premenopausal women (n = 2303). women.…”

Section: Discussionsupporting

confidence: 80%

“…Clinical implications may be significant as lower testosterone is associated with nonalcoholic steatohepatitis and with the degree of hepatic fibrosis 38 . Some studies in men measuring total testosterone in biopsy‐proven NAFLD have not found an inverse relationship though these sample sizes are generally less than 200 patients 39,40 . Our study showed a positive association between total testosterone and NAFLD in premenopausal women, as was noted in other studies, 41 but our study did not demonstrate an association between total testosterone and NAFLD in the postmenopausal women.…”

Section: Discussionsupporting

confidence: 68%

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Endogenous sex hormones and nonalcoholic fatty liver disease in US adults

Kim,

Manikat,

Cholankeril

et al. 2023

Liver International

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Background and AimsSex steroid hormones and sex hormone‐binding globulin (SHBG) have a role in predisposing individuals to nonalcoholic fatty liver disease (NAFLD), but their effects are known to differ between men and women. The testosterone‐to‐estradiol ratio (T/E2 ratio) and free androgen index (FAI) were known biomarkers for the hormonal milieu. We investigated whether sex steroid hormones, T/E2 ratio, FAI, and SHBG were associated with NAFLD in US adults.MethodsA cross‐sectional analysis using the 2013–2016 National Health and Nutrition Examination Survey (NHANES) was performed. NAFLD was defined by utilizing the Hepatic Steatosis Index (HSI) and the US fatty liver index (USFLI) without other causes of chronic liver disease.ResultsOut of 8687 subjects (49.5% male), low total testosterone levels were associated with progressively higher odds of NAFLD in men. Increasing T/E2 ratio was inversely associated with higher odds of NAFLD in men. Low serum SHBG levels were independently associated with an increased risk of NAFLD regardless of sex and menopausal status. Increasing FAI was independently associated with NAFLD. When we additionally adjusted for SHBG, T/E2 ratio, not total testosterone, was inversely associated with NAFLD in a dose‐dependent manner. Increasing FAI was associated with higher odds of NAFLD in premenopausal women and marginally associated with NAFLD in postmenopausal women.ConclusionThe T/E2 ratio and SHBG were inversely associated with an increased risk of NAFLD in men. In women, increasing FAI was associated with NAFLD, whereas SHBG was inversely associated with NAFLD.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 68%

Endogenous sex hormones and nonalcoholic fatty liver disease in US adults

Kim,

Manikat,

Cholankeril

et al. 2023

Liver International

View full text Add to dashboard Cite

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The relationship between follicle-stimulating hormone and metabolic dysfunction-associated fatty liver disease in men

Bin,

Liu,

Peng

et al. 2024

Nutr. Diabetes

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Objectives The present study aimed to investigate the relationship between male hormones and metabolic dysfunction-associated fatty liver disease (MAFLD) in males. Methods Data from the Fangchenggang Area Male Health and Examination Survey (FAMHES) were used to analyze the male hormone levels between MAFLD patients and controls. Univariate and multivariate logistic regression analyses were performed to identify risk factors for MAFLD. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of male hormones for MAFLD. Result A total of 1578 individuals were included, with 482 individuals (30.54%) of MAFLD, including 293 (18.57%) with mild disease and 189 (11.98%) with moderate-to-severe disease. The MAFLD patients were significantly older than those without MAFLD. The LH, FSH, and SHBG levels in the MAFLD patients were significantly greater than those in the control group. Age, FSH, LH, SHBG, and estradiol were all risk factors for MAFLD. Age, FSH, and LH were risk factors for moderate-to-severe MAFLD. FSH was an independent risk factor for MAFLD and moderate-to-severe MAFLD. FSH showed an excellent diagnostic value, with an AUC of 0.992 alone and 0.996 after adjusting age. Conclusions Our findings indicate that FSH may be a potential diagnostic and predictive biomarker for MAFLD.

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A cross-sectional analysis of the association between testosterone and biopsy-proven non-alcoholic fatty liver disease in men with obesity

Cited by 2 publications

References 32 publications

Endogenous sex hormones and nonalcoholic fatty liver disease in US adults

Endogenous sex hormones and nonalcoholic fatty liver disease in US adults

The relationship between follicle-stimulating hormone and metabolic dysfunction-associated fatty liver disease in men

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