A Cross-sectional and Longitudinal Study of Fuchs Uveitis Syndrome in Turkish Patients

In vivo confocal microscopic evaluation of keratic precipitates and endothelial morphology in Fuchs’ uveitis syndrome

“…We included cases with unilateral involvement as FUS is typically unilateral and only 5-10% of cases are reported to have bilateral involvement. 5,22 One limitation of IVCM is the difficulty in obtaining images from the peripheral cornea. As one moves the immersion lens closer to the limbus, the lens can only get oblique images of the cornea with insufficient field of view and thus peripheral cornea is inadequately visualized unless the patient makes a very accurate vertical realignment movement so that the peripheral cornea is realigned with the horizontal axis of the immersion lens.…”

“…All patients included in the study had a diagnosis of FUS. The diagnosis of FUS was established on the detection of the following clinical features by a senior consultant of the Uveitis service (SK), as elaborated in a previous large-scale clinical study: 5 the presence of low-grade (r þ 2 cells in the anterior chamber) anterior chamber reaction not associated with posterior synechiae; nongranulamotous small-medium sized KP as detected with slit-lamp biomicroscopy; diffuse stromal iris atrophy with or without heterochromia; unilateral presentation; absence of pain, photophobia, or ciliary injection; absence of posterior segment involvement including retinal infiltrates, retinal vasculitis, posterior chorioretinal scars or cystoid macular edema, and absence of evidence for another distinct infectious/immunological cause for intraocular inflammation. Patients with a previous history of intraocular trauma or disease were not included.…”

“…Under slit-lamp biomicroscopy, they are distinguished by their classical, although less commonly observed, fine stellate-shaped appearance or relatively more frequently observed medium-sized precipitates. 5 Obviously, identification of a distinct KP morphology with FUS would be extremely helpful in correctly identifying eyes with FUS as well as understanding the pathophysiology of this disease.…”

“…3 In the paucity of classical findings, FUS is difficult to diagnose; in fact, only 10-50% of cases with FUS are identified at initial presentation. 4,5 Correct diagnosis of FUS is essential as misdiagnosis of this syndrome is associated with the administration of unnecessary and potentially harmful topical and systemic immunosuppressive therapy. 5 The KP observed in FUS have been noted to have certain morphologic features that may be diagnostically helpful.…”

“…4,5 Correct diagnosis of FUS is essential as misdiagnosis of this syndrome is associated with the administration of unnecessary and potentially harmful topical and systemic immunosuppressive therapy. 5 The KP observed in FUS have been noted to have certain morphologic features that may be diagnostically helpful. Under slit-lamp biomicroscopy, they are distinguished by their classical, although less commonly observed, fine stellate-shaped appearance or relatively more frequently observed medium-sized precipitates.…”