A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community

Muzembo, Basilua Andre; Nagano, Yasunori; Eitoku, Masamitsu; Ngatu, Nlandu Roger; Matsui, Teppei; Bhatti, Sabah; Hirota, Ryoji; Ishida, Kenji; Suganuma, Narufumi

doi:10.1007/s12199-013-0350-x

Cited by 9 publications

(5 citation statements)

References 41 publications

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“…The other studies reported similar findings [1,22]. However, the present study did not find a difference in HGS between the right and left hands; this is in accordance with the study by Muzembo et al [23].…”

Section: Discussionsupporting

confidence: 93%

Handgrip Strength and Its Associated Factors among Community-dwelling Elderly in Sri Lanka: A Cross-sectional Study

Damayanthi

Moy

Abdullah

et al. 2018

Asian Nursing Research

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Section: Discussionsupporting

confidence: 93%

Handgrip Strength and Its Associated Factors among Community-dwelling Elderly in Sri Lanka: A Cross-sectional Study

Damayanthi

Moy

Abdullah

et al. 2018

Asian Nursing Research

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“…In addition, urinary 8-oxo-dGuo levels in control subjects in our study were observed to be higher than those of healthy subjects in previous studies employing ELISA [ 28 , 29 ], although the levels found in this study were comparable to those reported by Ksiazek et al [ 30 ]. The urinary 8-oxo-dGuo levels were usually higher and variable when detected by ELISA compared with chromatographic methods.…”

Section: Discussionsupporting

confidence: 73%

A Case‐Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal

Chaisiriwong

Wanitphakdeedecha

Sitthinamsuwan

et al. 2016

Oxidative Medicine and Cellular Longevity

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Oxidative damage has been suggested to play a role in the pathogenesis of basal cell carcinoma (BCC). This study illustrated an involvement of oxidative DNA damage and changes in antioxidant defenses in BCC by conducting a case-control study (24 controls and 24 BCC patients) and assessing urinary 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo), plasma antioxidant defenses including catalase (CAT), glutathione peroxidase (GPx), NQO1, and total superoxide dismutase (SOD) activities, and glutathione (GSH) levels before surgery and 1 month after surgery. 8-oxo-dGuo expressions as well as protein and mRNA expressions of DNA repair enzyme hOGG1 and antioxidant defenses (CAT, GCLC, GPx, Nrf2, and MnSOD) in nonneoplastic epidermis of control and BCC tissues were also determined. This study observed induction in urinary 8-oxo-dGuo, increased 8-oxo-dGuo expression, and reduced hOGG1 protein and mRNA in BCC tissues, decreased activities of CAT, GPx, and NQO1, but elevated SOD activities and GSH levels in BCC patients and reduction of all antioxidant proteins and genes studied in BCC tissues. Furthermore, decreased plasma antioxidant activities in BCC patients were restored at 1 month after operation compared with preoperative levels. Herein, we concluded that BCC patients were associated with oxidative DNA damage and depletion of antioxidant defenses and surgical removal of BCC correlated with improved redox status.

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“…The prevalence of an inadequate nutritional status and of risk for malnutrition in older adults in Europe and North America ranges up to 85% depending on whether participants comprise of non-institutionalized or residents from geriatric care facilities, hospitals, or long-term nursing homes [7,8]. Specifically, older institutionalized individuals are experiencing a rapid decline of physical function often accompanied and partly caused by malnutrition and physical inactivity as soon as they change their living situation from “free-living” into an institutionalized surrounding [9,10].…”

Section: Introductionmentioning

confidence: 99%

Fat Soluble Vitamins in Institutionalized Elderly and the Effect of Exercise, Nutrition and Cognitive Training on Their Status—The Vienna Active Aging Study (VAAS): A Randomized Controlled Trial

et al. 2019

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Background: Institutionalized elderly are at higher risk for micronutrient deficiency. In particular, fat soluble micronutrients, which additionally have antioxidative function, are of interest. The purpose of this secondary investigation of the Vienna Active Ageing Study was to assess and evaluate the plasma status of retinol, alpha- and gamma-tocopherol, alpha- and beta-carotene, lutein, zeaxanthin, beta-cryptoxanthin, and lycopene, as well as vitamin D (25(OH)D) in a cohort of institutionalized elderly. We further determined the effect of six months strength training with or without supplementing (antioxidant) vitamins and protein on the plasma status of these ten micronutrients. Methods: Three groups (n = 117, age = 83.1 ± 6.1 years)—resistance training (RT), RT combined with protein and vitamin supplementation (RTS), or cognitive training (CT)—performed two guided training sessions per week for six months. Micronutrients were measured with High Performance Liquid Chromatography (HPLC) at baseline and after 6 months of intervention. Physical fitness was assessed by the 6-min-walking, the 30-s chair rise, isokinetic dynamometry, and the handgrip strength tests. Results: At baseline, the plasma status of retinol was satisfactory, for alpha-tocopherol, beta-carotene, and 25(OH)D, the percentage of individuals with an insufficient status was 33%, 73% and 61%/81% (when using 50 nmol/L or 75 nmol/L as threshold levels for 25(OH)D), respectively. Plasma analyses were supported by intake data. Six months of elastic band resistance training with or without protein-vitamin supplementation had no biological impact on the status of fat soluble micronutrients. Even for vitamin D, which was part of the nutritional supplement (additional 20 µg/d), the plasma status did not increase significantly, however it contributed to a lower percentage of elderly below the threshold levels of 50/75 nmol/L (49%/74%). Conclusions: The findings of the study lead to the strong recommendation for regular physical activity and increased consumption of plant-based foods in institutionalized elderly. When supported by blood analysis, supplementing micronutrients in a moderate range should also be considered.

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A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community

Abstract: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.

Cited by 9 publications

References 41 publications

Handgrip Strength and Its Associated Factors among Community-dwelling Elderly in Sri Lanka: A Cross-sectional Study

Handgrip Strength and Its Associated Factors among Community-dwelling Elderly in Sri Lanka: A Cross-sectional Study

A Case‐Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal

Fat Soluble Vitamins in Institutionalized Elderly and the Effect of Exercise, Nutrition and Cognitive Training on Their Status—The Vienna Active Aging Study (VAAS): A Randomized Controlled Trial

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