A cross‐sectional evaluation of dermatopathology fellowship website content

Abstract

mammaglobin. [2][3][4][5][6][7][8] In addition, the vast majority of primary and metastatic breast carcinomas demonstrate CK20-negativity (CK20−) and CK7-positivity (CK7+) by immunohistochemistry. 2-8 Herein, we report a case of metastatic breast carcinoma to the skin with variant CK20+/CK7− immunophenotype.

CK20‐positive/CK7‐negative metastatic breast carcinoma to the skin

“…2 However, dermatopathologists often require a high index of suspicion for metastatic disease because of overlapping cytoarchitectural features among tumors and rarely aberrant/atypical immunohistochemical profiles. [3][4][5][6][7][8] Breast cancer is the most common tumor leading to the development of cutaneous metastases, accounting for approximately 69% of primary malignancies associated with skin deposits in women. 1 It is reported that up to 23.9% of patients with breast carcinoma can develop cutaneous metastases.…”

“…By immunohistochemistry, tumor cells are, C, positive for CK20 and, D, negative for CK7 (left, normal sweat glands as internal positive control) (A,C,D, original magnification ×200; B, original magnification ×400) mammaglobin. [2][3][4][5][6][7][8] In addition, the vast majority of primary and metastatic breast carcinomas demonstrate CK20-negativity (CK20−) and CK7-positivity (CK7+) by immunohistochemistry. [2][3][4][5][6][7][8] Herein, we report a case of metastatic breast carcinoma to the skin with variant CK20+/CK7− immunophenotype.…”

“…[2][3][4][5][6][7][8] In addition, the vast majority of primary and metastatic breast carcinomas demonstrate CK20-negativity (CK20−) and CK7-positivity (CK7+) by immunohistochemistry. [2][3][4][5][6][7][8] Herein, we report a case of metastatic breast carcinoma to the skin with variant CK20+/CK7− immunophenotype.…”

“…3 Only one prior example of CK20+/CK7− metastatic breast carcinoma has been reported in the literature. 8 This was a case of a 52-year-old woman with a previous history of breast cancer who presented with a growing cutaneous/ soft tissue mass below the right eyebrow. 8 The main goal of diagnosing skin metastases for dermatopathologists is to determine the histopathological type and primary site.…”

“…8 This was a case of a 52-year-old woman with a previous history of breast cancer who presented with a growing cutaneous/ soft tissue mass below the right eyebrow. 8 The main goal of diagnosing skin metastases for dermatopathologists is to determine the histopathological type and primary site. 2 A panel of immunostains is commonly employed, with a simple algorithm combining CK7 and CK20 used to direct further histopathological investigation.…”