2018
DOI: 10.1002/jmv.25315
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A cross‐sectional serum investigation of a clustering hepatitis C virus infection in Southwest China

Abstract: Serum samples were collected in a village with a clustering hepatitis C virus (HCV) infection. HCV antibody, HCV RNA loads, liver function indexes, HCV envelope antibody, and neutralizing activity were assessed. Among 851 adult sera, 342 samples were positive for anti-HCV. Of these positive samples, 254 (74.3%) were HCV RNA positive (≥800 copies/mL). None of the 69 children's sera were positive for HCV antibody or RNA. Among the HCV antibody positive sera, alanine aminotransferase, and aspartate aminotransfera… Show more

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“…This high liver cancer mortality probably can be attributed to HBV/HCV infection, as HBV infection rate was much higher in Yunnan (49.92/100,000) when compared with other regions in China, like Jiangsu province (16.17/100,000) and Shanghai (35.07/100,000) ( 22 ). Besides, Yunnan province is also an important epidemic center for blood-borne viruses such as HCV ( 23 , 24 ). Meanwhile, Yunnan province is an economically underdeveloped region locates in southwest border of China.…”
Section: Discussionmentioning
confidence: 99%
“…This high liver cancer mortality probably can be attributed to HBV/HCV infection, as HBV infection rate was much higher in Yunnan (49.92/100,000) when compared with other regions in China, like Jiangsu province (16.17/100,000) and Shanghai (35.07/100,000) ( 22 ). Besides, Yunnan province is also an important epidemic center for blood-borne viruses such as HCV ( 23 , 24 ). Meanwhile, Yunnan province is an economically underdeveloped region locates in southwest border of China.…”
Section: Discussionmentioning
confidence: 99%