A cross-sectional study exploring the relationship between Oxidative Balance Scoreand and 10-Year Atherosclerotic Cardiovascular Disease Risk based on the National Health and Nutrition Examination Survey (2011-2020).

Abstract

Background The association between the Oxidative Balance Score (OBS) and the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) remains unclear. The objective of our study was to investigate the relationship between OBS and 10-year ASCVD risk. Methods A total of 4,955 participants were included from the National Health and Nutrition Examination Surveys (NHANES). OBS was calculated based on nutritional and lifestyle factors. Multivariable logistic regression analysis was conducted to explore the association between OBS and 10-year ASCVD risk. Linear relationships were examined using restricted cubic spline methods. Stratified analyses were performed to assess the robustness of the results. Results We included 4,955 participants, and the results of the multivariable logistic regression analysis showed that, when compared to the first quartile, individuals in the highest quartile of total OBS were negatively associated with 10-year ASCVD risk (OR: 0.59, 95% CI: 0.42–0.83, P = 0.002), with a significant trend (P = 0.003). Lifestyle OBS and dietary OBS were also significantly negatively associated with 10-year ASCVD risk (OR: 0.18, 95% CI: 0.12–0.27; OR: 0.78, 95% CI: 0.63–0.98, P = 0.03), with significant decreasing trends (P for trend < 0.05). Stratified analyses revealed that race and hypertension were effect modifiers in the relationship between OBS and 10-year ASCVD risk (P for interaction < 0.05). Conclusion Our study demonstrates a negative linear relationship between higher OBS and 10-year ASCVD risk, suggesting the crucial importance of antioxidant-rich dietary and lifestyle choices in reducing ASCVD risk.