A Cross Sectional Study of Association Between Serum Uric Acid and Lipid Profile

Abstract

Background: The association of Serum Uric Acid (SUA) with Lipid Prole is not well studied or little is known so far, although the link between elevated uric acid and metabolic syndrome has been reported in some studies. This study was conducted to establish the relationship between SUA and Lipid Prole among the general adults. Methods: 560 blood samples were collected from general adult participants (male, n = 300 & female, n = 260) were analysed for serum lipid prole (TC, TG, HDL and LDL) and SUA levels. The study subjects were divided by quartiles based on SUA levels (Q1: ≤225 μmol/L, Q2: 226–285 μmol/L, Q3: 286–340 μmol/L and Q4: > 340 μmol/L). Linear regression modelling was used to evaluate the relationship between SUA and Lipid levels. Results: The prevalence of hyperuricemia was 9.2% in males and 10.4% in females. The mean level of SUA was signicantly higher in male (317 ± 90 μmol/L) than in the female (255 ± 65 μmol/L) subjects (p < 0.001). An increasing trend for elevated lipid prole was observed in both genders with increasing levels of SUA in the quartiles (p < 0.05). In regression analysis, a signicant positive correlation was found between SUA and TG, TC and LDL (p < 0.01) while an inverse correlation was observed between SUA and HDL (p < 0.01). After adjusting for potential confounders, lipid prole was linearly associated with SUA levels (p < 0.01 for trend). Conclusions: Lipid parameters (TG, TC, and LDL levels) increases with increase in SUA, whereas HDL decreases with rise in SUA. Cardiovascular risks may be reduced by early prevention of hyperuricemia and dyslipidaemias.