A cross-sectional study of functional disabilities and perceived cognitive dysfunction in patients with major depressive disorder in South Korea: The PERFORM-K study

Kim, Jae Min; Chalem, Ylana; Nicola, S. Di; Hong, Jin Pyo; Won, Seunghee; Miléa, D.

doi:10.1016/j.psychres.2016.01.022

Cited by 54 publications

(60 citation statements)

References 41 publications

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“…Cognitive dysfunction is highly prevalent in people with depression and has a significant impact on functioning (Jaeger et al, 2006;McIntyre et al, 2013;Shilyansky et al, 2016). In a recent, cross-sectional, observational study in South Korea, greater functional disability and impairment in daily activities, including worse work-related productivity outcomes, were associated with more severe perceived cognitive dysfunction (Kim et al, 2016). The domains of executive function, working memory, episodic memory, attention and psychomotor processing speed are commonly affected in people with depression (McIntyre et al, 2013;Shilyansky et al, 2016), with poorer performance in neuropsychological tests being in the order of small (0.2) to medium (0.5) effect sizes compared to healthy individuals (Lee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Analysing UK clinicians’ understanding of cognitive symptoms in major depression: A survey of primary care physicians and psychiatrists

McAllister-Williams

Bones

Goodwin

et al. 2017

Journal of Affective Disorders

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Background: Cognitive dysfunction occurs in depression and can persist into remission. It impacts on patient functioning but remains largely unrecognised, unmonitored and untreated. We explored understanding of cognitive dysfunction in depression among UK clinicians.Methods: A multi-step consultation process.Step 1: a multi-stakeholder steering committee identified key themes of burden, detection and management of cognitive dysfunction in depression, and developed statements on each to explore understanding and degree of agreement among clinicians.Step 2: 100 general practitioners (GPs) and 100 psychiatrists indicated their level of agreement with these statements.Step 3: the steering committee reviewed responses and highlighted priority areas for future education and research.Results: There was agreement that clinicians are not fully aware of cognitive dysfunction in depression. Views of the relationship between cognitive dysfunction and other depressive symptom severities was not consistent with the literature. In particular, there was a lack of recognition that some cognitive dysfunction can persist into remission. There was understandable uncertainty around treatment options, given the current limited evidence base. However, it was recognised that cognitive dysfunction is an area of unmet need and that there is a lack of objective tests of cognition appropriate for depressed patients that can be easily implemented in the clinic.Limitations: Respondents are likely to be 'led' by the direction of the statements they reviewed. The study did not involve patients and carers. Conclusions: UK clinicians should undergo training regarding cognitive dysfunction in depression, and further research is needed into its assessment, treatment and monitoring.

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Section: Introductionmentioning

confidence: 99%

Analysing UK clinicians’ understanding of cognitive symptoms in major depression: A survey of primary care physicians and psychiatrists

McAllister-Williams

Bones

Goodwin

et al. 2017

Journal of Affective Disorders

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“…In the current study cognitive impairment was significantly affected by the severity of depression, where the total score of cognitive impairment increased with severity of depression (P-value=0.001). A previous study (Miskowiak, et al 2012) suggested that severity of depression may be a predictor of cognitive impairment, while other previous studies (Fava, et al 2009;kim, et al 2016), reported a weak association between cognitive dysfunction and depression severity. In a study from Japan on participants aged 65 years and older, it was reported that cognitive impairment was more common in persons with depression (Hidaka, et al 2012).…”

Section: Discussion:-mentioning

confidence: 92%

“…Cognitive impairment in retrospective memory domain was the highest among the other domains, the mean scores for individuals regarding memory (retrospective and prospective) increased by increasing the severity of depression (P-value=0.001), however (Kim, et al 2016;Lam, et al 2013) revealed that planning/organization and concentration/attention domains were predominances than memory domain. Regarding planning of individuals, the impairment of planning was increased with the severity of depression (P-value=0.001).…”

Section: Discussion:-mentioning

confidence: 93%

“…The given results will be needed to guide clinical decision and improve the outcomes. Kim et al (2016) investigated functional disability, productivity and quality of life in MDD outpatients in South Korea, and the associations of these with depressive symptoms, perceived cognitive dysfunction and other factors. A total of 312 outpatients who started antidepressant monotherapy underwent a single study interview.…”

Section: Issn: 2320-5407mentioning

confidence: 99%

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Functional Disability Among Patients With Depressive Disorder Associated With Cognitive Impairment at King Abdulaziz Hospital- Makkah.

Alsalem.¹

2017

IJAR

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Background: Depression is a mood disorder that results in negative thoughts, disruption of thinking, sleep and appetite. A depressive disorder is occurring with cognitive impairment, and depressed patients tend to suffer decreased performance. The study aims to assess the incidence of depressive disorder and its association with functional disability and cognitive impairment. Determine the impact of a depressive disorder associated with cognitive impairment on functional disability among patients. Methods: This study is descriptive cross-sectional which included 150 patients from Makkah and treated at King Abdulaziz Hospital. Results: The mean age of patients in this study was 36.12±10.93, the male and female were in equal ratio 1:1. The most prevalent degree of depression was severe depression 31.3%, followed by mild depression 29.3%, no depression 20.7% and finally moderate depression 18.7%. Age, sex, education, and occupation significantly affected the severity of depression. There was a positive correlation between cognitive dysfunction and functional disability (P-value=0.001, r=0.433), with a strong positive correlation to family life (P-value=0.001, r=0.71). Conclusion: Severe depression was the most prevalent degree of depression, and it was significantly associated with cognitive impairment, functional disability and decreased work productivity. The increase in the severity of depression was related to the greater cognitive impairment and increase in functional disability as well as work productivity. Functional disability increases with increasing in cognition dysfunction.

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“…There is evidence that cognitive dysfunction is related to poor social functioning in patients with depressive disorders (Kim et al 2016;Woo et al 2016). It has been reported that cognitive dysfunction is already present at an early stage of depressive disorders and is maintained even in remission (Woo et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Psychotropic Prescribing Patterns Associated with impaired Concentration in Asians with Depressive Disorders: The REAP-AD Study

Park

Lee

Hahn

et al. 2017

Tohoku J. Exp. Med.

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The Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) study aimed to survey and review antidepressant prescribing patterns in different clinical settings in Asian countries/areas. The REAP-AD study collected comprehensive data for psychiatric patients prescribed antidepressants in 10 Asian countries/areas during the period from March to June 2013. Depressive disorders have been an important issue closely associated with ill-health and disability in the realm of mental health. Impaired concentration was found to be a consistent symptom in depressive disorders regardless of clinical course, and a predictor of poor treatment outcome. In this work we aimed to identify clinical characteristics independently associated with impaired concentration in patients with depressive disorders, using data from the REAP-AD study. A total of 336 depressive disorder patients with impaired concentration and 786 depressive disorder patients without impaired concentration were recruited from 40 centers in 10 Asian countries/areas. A binary logistic regression model was fitted to identify the independent correlates of impaired concentration in patients with depressive disorders. After adjusting the effects of covariates, the binary logistic model showed that impaired concentration was independently associated with higher rates of loss of interest (P < 0.0001), fatigue (P < 0.0001), low self-confidence (P < 0.0001) and appetite disturbance (P < 0.0001) and with a lower rate of adjunctive antipsychotic prescription (P = 0.007). Our findings suggest that impaired concentration and its associated depressive symptom profiles constitute a unitary depressive symptom cluster that is also an intervening variable for poor social function.

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A cross-sectional study of functional disabilities and perceived cognitive dysfunction in patients with major depressive disorder in South Korea: The PERFORM-K study

Cited by 54 publications

References 41 publications

Analysing UK clinicians’ understanding of cognitive symptoms in major depression: A survey of primary care physicians and psychiatrists

Analysing UK clinicians’ understanding of cognitive symptoms in major depression: A survey of primary care physicians and psychiatrists

Functional Disability Among Patients With Depressive Disorder Associated With Cognitive Impairment at King Abdulaziz Hospital- Makkah.

Clinical Characteristics and Psychotropic Prescribing Patterns Associated with impaired Concentration in Asians with Depressive Disorders: The REAP-AD Study

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