A cross-sectional study of variations in the biophysical parameters of skin among healthy volunteers

Mehta, Hita; Nikam, Vivek V; Jaiswal, Chandrashekher R; Mehta, Hemant B

doi:10.4103/ijdvl.ijdvl_1151_15

Cited by 23 publications

(36 citation statements)

References 15 publications

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“…We next assessed the epidermal permeability barrier function in these subjects. In agreement with previous findings [17], males exhibited higher basal TEWL rates in comparison to females ( Fig. 1a).…”

Section: Uninvolved Skin Site Of Subjects With Hand Eczema Displays Csupporting

confidence: 93%

Altered Epidermal Permeability Barrier Function in the Uninvolved Skin Supports a Role of Epidermal Dysfunction in the Pathogenesis of Occupational Hand Eczema

Wang

Lai³

et al. 2020

Skin Pharmacol Physiol

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Although a compromised epidermal permeability barrier can contribute to the development of contact dermatitis, whether subjects with hand eczema display abnormalities in baseline epidermal permeability barrier function in their uninvolved skin remains unknown. The aim of the present study was to assess epidermal permeability barrier function in subjects with and without hand eczema in clothing manufacturers. Upon approval by the institutional review board, volunteers were recruited from clothing manufacturers in Guangzhou City, China. An 11-item questionnaire was used to collect general data from the volunteers. The diagnoses of self-proclaimed hand eczema were further confirmed by a dermatologist. Epidermal biophysical properties, including transepidermal water loss (TEWL) rates, stratum corneum hydration and skin surface pH were measured on the flexural surface of the left forearm in all volunteers. Epidermal biophysical properties were compared among cohorts of subjects with active hand eczema, a prior history of hand eczema and without any history of hand eczema. A total of 650

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Section: Uninvolved Skin Site Of Subjects With Hand Eczema Displays Csupporting

confidence: 93%

Altered Epidermal Permeability Barrier Function in the Uninvolved Skin Supports a Role of Epidermal Dysfunction in the Pathogenesis of Occupational Hand Eczema

Wang

Lai³

et al. 2020

Skin Pharmacol Physiol

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“…Skin measurement tools were extracted by literature search and by exploring their PubMed MeSH-terms. 4,[22][23][24][25]28 We defined 'noninvasive' as every method that theoretically cannot lead to skin irritation, bleeding or scarring; this excluded biopsies, epilation of eyelashes/hairs, application of tape or glue onto the skin, and collection of skin scrapings or excretions from sebaceous follicles. Only studies involving adult patients with cutaneous facial rosacea were included (Table S1; see Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

“…A variety of noninvasive objective skin measurements exist. [22][23][24][25] These techniques are widely used in rosacea, but a comprehensive overview is lacking. This systematic review elucidates the spectrum of available noninvasive objective skin measurement techniques for rosacea.…”

Section: What Does This Study Add?mentioning

confidence: 99%

“…The advantage of noninvasive over invasive techniques is the ability to monitor the same facial skin location over time without causing irritation, damage or alteration, including inflammatory responses, which may interfere with diagnosis and evaluation. A variety of noninvasive objective skin measurements exist . These techniques are widely used in rosacea, but a comprehensive overview is lacking.…”

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confidence: 99%

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Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

et al. 2019

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Summary Background Rosacea assessment and therapy monitoring can be challenging to standardize, as most clinical evaluation systems are prone to interobserver variability and not always validated. Therefore, objective, reliable and preferably noninvasive measurement tools are needed. Objectives To give insight into available noninvasive imaging techniques and biophysical methods in rosacea by performing a systematic review. Methods PubMed, Embase, Cochrane and Web of Science databases were searched until 1 September 2018 in accordance with PRISMA guidelines, to identify studies providing original data about objective noninvasive imaging and/or biophysical skin measurement techniques for diagnosis, assessing severity or therapy monitoring of adult patients with cutaneous facial rosacea. Risk of bias of included articles was assessed with the Cochrane Risk of Bias tool, Quality in Prognosis Studies tool, and the Newcastle–Ottawa Scale. Results A total of 78 studies were included, describing 14 imaging and biophysical methods. Widespread information about (sub)surface cutaneous morphology and functionality was obtained. Methodological study quality was relatively low and interstudy outcome variability was large. Several tools show promising value in research settings: for treatment follow‐up Demodex mites are countable with reflectance confocal microscopy, spectrometry can quantify erythema, and rosacea severity could be objectified with skin hydration‐ and transepidermal water loss measurements. Conclusions This systematic review describes the spectrum of noninvasive imaging and biophysical methods in rosacea assessment, giving multifaceted information about structure and properties of rosacea skin, especially useful for research purposes. Larger studies with good methodological quality are needed to create validated protocols for further implementation into research. What's already known about this topic? Rosacea is a chronic inflammatory skin disease with a variety of clinical manifestations. Most clinical evaluation systems are subjective, not always validated, and subsurface skin processes remain unnoticed. Currently, different types of noninvasive measurement tools are available for rosacea assessment and therapy monitoring, but a comprehensive overview is lacking. What does this study add? Seventy‐eight publications were included, describing 14 imaging and biophysical tools, providing a wide range of information about rosacea skin morphology and functionality. Reflectance confocal microscopy and spectrometry are especially promising in therapy monitoring and skin barrier measurements for rosacea severity assessment. Larger studies with better methodological quality are needed to create validated protocols for implementation into research.

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“…On the other hand, TEWL of non-lesional forehead skin had a low correlation with triols. This may have been because the amount of triols was lower than that of forearm or due to another anatomical difference associated with this site [34]. In healthy subjects, such correlation was not observed in both forehead and forearm skin.…”

Section: Discussionmentioning

confidence: 99%

Measurement of trihydroxy-linoleic acids in stratum corneum by tape-stripping: Possible biomarker of barrier function in atopic dermatitis

et al. 2019

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Epidermal ceramides are indispensable lipids that maintain the functions of the stratum corneum. Esterified omega-hydroxyacyl-sphingosine (EOS) ceramide with a linoleate moiety is one of the most important ceramide species for forming cornified lipid envelopes. This linoleate moiety is eventually metabolized to trihydroxy-linoleic acid (triol, 9,10,13-trihydroxy-11E-octadecenoic acid). Thus, we assumed that a decrease of triols might reflect skin barrier dysfunction. Against this background, the purposes of this study were to measure the triols by a simple tape-stripping method and to determine the correlation between the amount of triols and transepidermal water loss (TEWL) as an indicator of barrier dysfunction in atopic dermatitis patients. Twenty Japanese subjects with normal skin and 20 atopic dermatitis patients were enrolled in this study. TEWL was measured and triols of the stratum corneum were analyzed by tape-stripping. The results showed for the first time that triols in the stratum corneum could be simply measured using the tape-stripping method. The triol levels in atopic dermatitis patients were much higher than those in healthy subjects. Moreover, the triol levels correlated with TEWL of non-lesional forearm skin in patients with atopic dermatitis. The results suggest that the assaying of triol levels via non-invasive tape-stripping could be beneficial for monitoring barrier function in atopic dermatitis.

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A cross-sectional study of variations in the biophysical parameters of skin among healthy volunteers

Abstract: Skin properties vary with age, gender, and location on the body. This knowledge will help to create a database of these parameters in the Indian population. It would assist in the diagnosis of various clinical conditions and monitor therapeutic response.

Cited by 23 publications

References 15 publications

Altered Epidermal Permeability Barrier Function in the Uninvolved Skin Supports a Role of Epidermal Dysfunction in the Pathogenesis of Occupational Hand Eczema

Altered Epidermal Permeability Barrier Function in the Uninvolved Skin Supports a Role of Epidermal Dysfunction in the Pathogenesis of Occupational Hand Eczema

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

Measurement of trihydroxy-linoleic acids in stratum corneum by tape-stripping: Possible biomarker of barrier function in atopic dermatitis

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