A cross‐sectional study on clinical correlates of anxiety disorders in 613 community living older adults in Hong Kong

Fung, Ada Wai Tung; Lam, Linda Chiu Wa

doi:10.1002/gps.4516

Cited by 9 publications

(13 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, this is the first prospective study that provided a well‐matched comparison based on age, gender, and education to a large group of anxious older adults without dementia. We have previously reported a cross‐sectional linkage in anxiety and cognitive impairment in non‐demented older adults . At 3 years, we found that baseline anxiety symptoms were associated with poor performance in delayed recall and TMT at follow‐up.…”

Section: Discussionmentioning

confidence: 77%

“…The baseline study was conducted from 2011 and 2013. These individuals were selected from a larger pool of 613 community‐dwelling older adults . They were matched with another 122 participants without anxiety symptoms at baseline based on age, gender, and education in the same pool.…”

Section: Methodsmentioning

confidence: 99%

“…Until recently, increasing cross‐sectional findings indicated that anxiety has been linked to cognitive impairment in healthy older adults without dementia . Researchers begin to postulate that anxiety may be an early sign of neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

“…The objective of the current study was to extend a previous observation on the cross-sectional linkage between anxiety disorders and episodic memory impairment in a local healthy sample without dementia. 11 We hypothesized that baseline anxiety symptoms were predictive of episodic memory decline over a 3-year period.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Anxiety symptoms predicted decline in episodic memory in cognitively healthy older adults: A 3‐year prospective study

Fung

Lee

et al. 2018

Int J Geriat Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 77%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Anxiety symptoms predicted decline in episodic memory in cognitively healthy older adults: A 3‐year prospective study

Fung

Lee

et al. 2018

Int J Geriat Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Anxiety disorders in the elderly appear to be more likely associated with common medical conditions than those found in the general population [7]. Comorbid anxiety can complicate a patient’s medical treatment and outcome.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Management of Anxiety Disorders in the Elderly

Crocco

Jaramillo

Cruz-Ortiz

et al. 2017

Curr Treat Options Psych

View full text Add to dashboard Cite

Opinion Statement Anxiety disorders are common in the elderly. Additionally, anxiety symptoms often accompany co-morbid psychiatric, medical, as well as neurodegenerative diseases in the older population. Anxiety in the elderly, often accompanied by depression, can lead to worsening physical, cognitive and functional impairments in this vulnerable population. Antidepressants are considered first line treatment. Both SSRIs and SNRIs are efficacious and well-tolerated in the elderly. Some SSRIs are strong inhibitors of the cytochrome P450 hepatic pathway whereas others have less potential for drug interaction. Those antidepressants with more favorable pharmacokinetic profiles should be considered first-line in the treatment of anxiety. Mirtazapine and vortioxetine are also considered safe treatment options. Buspirone may have benefit, but lacks studies in elderly populations. Although tricyclic/tetracyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) may be effective in the elderly, their side effect and safety profiles are suboptimal and thus are not recommended in late-life. Benzodiazepines and beta blockers should generally be avoided when treating anxiety in the elderly. There is not enough evidence to support the use of antipsychotics or mood stabilizers given their risk of problems in both the long and short term. In addition, antipsychotics have a black box warning for increased mortality in elderly patients with dementia.

show abstract

Cognition

Young¹

2021

Burger's Medicinal Chemistry and Drug Discovery

View full text Add to dashboard Cite

Cognition can be defined as neurocognitive processes of how humans learn and remember. As humans age, threats of neurocognitive disturbances are probably the most feared psychiatric problems, but these processes also can be disrupted by biological abnormalities closely connected to other psychiatric problems. The theme of this article is that basic research in areas of cognition and advances in the discovery of novel pharmacotherapy for neurocognitive and psychiatric disorders that affect the elderly are inextricably intertwined. Drug evaluations in animal models should be conducted in, three basic types of learning/memory paradigms (habituation, classical conditioning, and operant conditioning) and should assess the effects of agent on learning, retention, and retrieval. The importance of this strategy involves issues of single or multiple learning processes in the paradigms, whether different types of paradigms give rise to different kinds of memories or whether the same paradigm may produce several fundamentally different types of memories that may or may not be interdependent. Medications currently in use for ameliorating neurocognitive disorders are mostly ineffective. New pharmacotherapy is urgently needed, and a seemingly innumerable collection of drugs has been proposed as the latest “key” to unlock mechanisms of dysfunction in neurocognition. In some cases, new agents have functioned (biochemically) exactly as advertised, but virtually all have proved unacceptable for clinically use. Future therapies for neurocognitive disorders will likely benefit from the recognition that multiple cellular mechanisms and neurotransmitter processes are involved and that administration of combinations of agents that provide “wide‐spectrum” actions may be most useful.

show abstract

A cross‐sectional study on clinical correlates of anxiety disorders in 613 community living older adults in Hong Kong

Cited by 9 publications

References 22 publications

Anxiety symptoms predicted decline in episodic memory in cognitively healthy older adults: A 3‐year prospective study

Anxiety symptoms predicted decline in episodic memory in cognitively healthy older adults: A 3‐year prospective study

Pharmacological Management of Anxiety Disorders in the Elderly

Cognition

Contact Info

Product

Resources

About