A cross-sectional study on coronary artery disease diagnosis in patients with peripheral artery disease

<abstract>Coronary artery disease (CAD) affects over 20 million Americans and its spectrum of impact leads to an estimated 7 million deaths, as well as the loss of 129 million disability-adjusted life years, worldwide, each year. CAD develops as atherosclerotic plaque forms in the coronary arteries. These plaques can eventually limit blood flow to myocardial tissue resulting in ischemia a risk for acute plaque rupture and acute coronary syndrome. While chest pain may represent a wide array of underlying diseases, given the high morbidity and mortality associated with CAD, an ischemic cardiac etiology must always be considered. Early diagnosis and treatment of CAD can improve patient outcomes through guiding risk factor modification and treatment modalities including medical and invasive approaches. While discovering coronary disease early can allow for treatments which can yield great benefit13, many tests are equivocal and can be associated with additional risk and unnecessary cost. This leaves the question; if there is some concern for stable CAD, who should we test, and which modality should be used? This comprehensive review aims to describe the available CAD testing modalities, detail their risks and benefits, and describe when each should be considered in the evaluation of a patient with suspected CAD. (Central illustration)</abstract>

show abstract

Can simultaneous coronary and peripheral angiography alter the treatment planning in Fontaine stage IV peripheral arterial disease?

Vaezzadeh,

Tayebi,

Jalali

et al. 2024

Vascular

View full text Add to dashboard Cite

Objectives Peripheral arterial disease (PAD) and coronary artery disease (CAD) are major contributors to global morbidity and mortality. Many PAD patients remain asymptomatic for CAD, which often leads to undetected coronary artery involvement. This hidden coronary disease poses significant risks, particularly following peripheral revascularization, as increased cardiac demand can precipitate complications. Methods This cross-sectional descriptive study assessed the prevalence of coronary artery stenosis in patients with Fontaine Stage IV peripheral arterial disease. Simultaneous angiography of both the coronary and lower extremity arteries was performed, and the severity of arterial stenosis was rigorously evaluated. The correlation between the extent of peripheral and coronary artery disease was analyzed. Results A total of 60 patients (63.3% male, 36.7% female; mean age 65.23 ± 9.86 years) were included. Comorbidities were common, with 90% having diabetes, 50% hypertension, 23.3% hyperlipidemia, and 30% smoking history. Severe peripheral artery stenosis was frequently observed, particularly in the posterior tibial artery (total occlusion in 26.6% and 20% of the right and left arteries, respectively). Significant coronary involvement was also prevalent, with 51.7% exhibiting three-vessel disease. Coronary revascularization was required in the majority of cases (CABG: 40%, PCI: 35%), with a higher proportion among women (77.2%) and men (73.7%). Conclusion This study highlights the necessity of comprehensive coronary evaluation in patients with advanced lower limb ischemia. A substantial proportion of these patients have silent but critical coronary disease, which, if left unaddressed, could result in serious post-revascularization complications.

show abstract

A cross-sectional study on coronary artery disease diagnosis in patients with peripheral artery disease

Cited by 5 publications

References 22 publications

An Investigative Approach to the Correlation and Prevalence of Peripheral Artery Disease in Diabetics in India

An Investigative Approach to the Correlation and Prevalence of Peripheral Artery Disease in Diabetics in India

Efficacy of Diagnostic Testing of Suspected Coronary Artery Disease: A Contemporary Review

Can simultaneous coronary and peripheral angiography alter the treatment planning in Fontaine stage IV peripheral arterial disease?

Contact Info

Product

Resources

About