A cross-sectional study on the postoperative analgesic-associated side effects and clinical parameters following partial mastectomy

Alizadeh, Reza; Aghsaeifard, Ziba; Alavi, Nazanin; Abbasvandi, Fereshteh; Khanigarabadi, Ali

doi:10.1016/j.ijso.2020.10.018

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…With the increased use of X-rays and gamma rays for various therapeutic and diagnostic purposes, potential health hazards have risen concerns 8 . The effect of ionizing radiation on increasing the risk of cancer as well as its other destructive effects on other organs of the body has been proven 9 – 11 . The main source of ionizing radiations for irradiators and other personnel is scattered or secondary ionizing radiations left over from the primary ionizing radiations 12 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biochemical parameters in operating room staff exposed to radiation and anesthetic gases

Rezaei,

Salehi Zahabi,

darvishi

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Exposure to ionizing radiations and other hazardous agents such as anesthetic gases pose serious risks to the health of healthcare workers. This study aimed to evaluate the changes in blood and biochemical parameters of the operating room staff exposed to ionizing radiations and remnants of anesthetic gas. Methods: This cross-sectional study was performed at (XXX). The control group was selected from different parts of the hospital that were not exposed to ionizing radiations and anesthetics, including office, services, and treatment. The case group included all operating room personnel. Hematopoietic parameters such as complete blood count and WBC differential, parameters of liver function such as serum activity of liver enzymes (ALT, AST, ALP, LDH) and serum bilirubin levels, fasting blood sugar, serum lipid profile, level of vitamin D and magnesium were measured for the exposed and referent subjects. Additionally, a checklist was used to gather data regarding the occupational variables and medical histories of the studied subjects. Results: The mean values of Hb, Hct, Vitamin D, and MCHC, as well as the RBC count, were significantly lower in the exposed individuals than in the referent subjects. In contrast, the proportion of smokers was significantly higher in the exposed group than in the referent group. No significant differences were noted between exposed and unexposed groups as far as other parameters were concerned. However, no significant differences were noted between case and control groups as far as other measured parameters were concerned. Likewise, no significant differences were noted between exposed and referent groups as far as blood types, history of underlying diseases, work history, working hours per month, number of morning and evening shift hours, type of diet, consumption of high-fat diet a day before blood sampling, x-ray in the recent year, history of radiotherapy and therapeutic agents use was concerned. Conclusions: Exposure of operating room staff to ionizing radiations and waste anesthetics gases is associated with subtle, sub-clinical pre-pathologic decreases in some hematopoietic parameters such as hemoglobin, hematocrit and MCHC levels, RBC count as well as Vitamin D levels.

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Section: Introductionmentioning

confidence: 99%

Evaluation of biochemical parameters in operating room staff exposed to radiation and anesthetic gases

Rezaei,

Salehi Zahabi,

darvishi

et al. 2023

Annals of Medicine &Amp; Surgery

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“…Katsuda et al ( 13 ) theorize that nerve terminals are heated by electric current in electrosurgical incisions of spine surgeries, and patients experience less discomfort during the recovery phase ( 13 ). A study found that using electrocautery for tissue dissection increases postoperative pain, necrosis, and severe tissue injury ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Comparing the intraoperative and postoperative complications of the scalpel and electrocautery techniques for severing the inner layers of the lumbar disc during discectomy surgery

Hajilo,

Imani,

Zandi

et al. 2023

Front. Surg.

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BackgroundDue to the sensitivity of the surgical site and a higher probability of injury, the use of a scalpel and electrocautery to create an incision in the spine is discussed. In this study, we will compare the intraoperative and postoperative complications of the scalpel and electrocautery techniques for severing the inner layers of the lumbar disc during discectomy surgery.Materials and methodsThis study was conducted in Iran as a randomized controlled trial with double-blinding (1,401). Sixty candidates for spine surgery were randomly divided into two groups of 30 using electrocautery (A) and a scalpel (B) based on available sampling. The VAS scale was used to assess postoperative pain. The duration of the incision and intraoperative blood loss were recorded. The infection and fluid secretions were determined using the Southampton scoring scale. Utilizing the Manchester scar scale, the wound healing status was evaluated. The SPSS version 16 software was used for data analysis (t-test, Mann–Whitney U, ANOVA).ResultsThe electrocautery group had substantially lower bleeding, pain, and wound healing rates than the scalpel group (P > 0.05). However, the electrocautery group had significantly longer surgical times, more secretions, and a higher infection rate than the scalpel group (P > 0.05). In terms of demographic and clinical characteristics, there was no significant difference between the two groups (P < 0.05).ConclusionElectrocautery reduces postoperative hemorrhage and, potentially, postoperative pain in patients. However, as the duration of surgery increases, so does the duration of anesthesia, and patient safety decreases. Additionally, the risk of infection increases in the electrocautery group compared to the scalpel group, and the rate of wound healing decreases. Clinical Trial Registrationhttps://www.irct.ir/, identifier (IRCT20230222057496N1).

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“…However, opioid use is associated with dose-dependent complications such as respiratory depression, nausea, vomiting, urinary retention, pruritus, drowsiness, or postoperative ileus [ 13 , 14 ]. Therefore, it seems reasonable to use compounds that can intensify the analgesic effects of narcotics and thus create better analgesic effects with less opioid use [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of preoperative melatonin on postoperative pain following cesarean section: A randomized clinical trial

Kiabi

Emadi

Jamkhaneh

et al. 2021

Annals of Medicine &Amp; Surgery

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Background Data regarding the analgesic effects of melatonin after the surgery is scare. So far, only one study has investigated the analgesic effect of melatonin during cesarean section. Objective : The present study was performed to investigate the effect of preoperative oral melatonin on pain intensity after cesarean section during spinal anesthesia. Methods In a double-blind randomized controlled clinical trial study, 204 patients undergoing elective cesarean section with class 1 and 2 anesthesia (ASA) were enrolled. Patients were randomly divided into 3 groups of 68 patients. Patients in group A were given 5 mg melatonin tablets, patients in group B were given 10 mg melatonin tablets, and group C was given placebo. All patients underwent spinal anesthesia with the same anesthesia protocol. Pain intensity, nausea, vomiting, pruritus and headache were assessed and recorded 2, 6, 12 and 24 h after surgery. The time of first dose of analgesia, the amount of opioid consumed within 24 h, and the time to resume physical activity was also recorded. Statistical analysis of data was performed using SPSS 20 software. Results Repeated measurements of pain intensity during the study showed that in all 3 groups pain intensity was significantly reduced during the study, p < 0.001, respectively. The intensity of pain was significantly different in groups B and C, groups B and A and groups A and C, P < 0.001, respectively. The pain reduction was greatest in group B, followed by group A and group C, respectively. The time interval between the end of surgery and the patient's need for analgesia was significant in group B compared to group A (P = 0.035) and C (P < 0.001) and also in group A compared to group C (P = 0.011). The mean dose of opioid was significantly least in group B, p < 0.001. The mean time to resume physical activity was also shortest in group B, p < 0.001 Headache and nausea/vomiting were observed in 7 patients (10.7%) group A and 7 patients (10.7%) in group C. None of the patients in group B developed complications. Conclusion The results of the present study showed that the use of 10 mg of melatonin before cesarean section with spinal anesthesia is not only safe, but also reduces the severity of patients' pain, increases the duration of postoperative analgesia, reduces the need for analgesics after surgery and resumption of physical activity.

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A cross-sectional study on the postoperative analgesic-associated side effects and clinical parameters following partial mastectomy

Cited by 10 publications

References 24 publications

Evaluation of biochemical parameters in operating room staff exposed to radiation and anesthetic gases

Evaluation of biochemical parameters in operating room staff exposed to radiation and anesthetic gases

Comparing the intraoperative and postoperative complications of the scalpel and electrocautery techniques for severing the inner layers of the lumbar disc during discectomy surgery

Effects of preoperative melatonin on postoperative pain following cesarean section: A randomized clinical trial

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