A cross-sectional study on the association between Helicobacter pylori infection and headache

Cavestro, Cinzia; Prandi, Giancarlo; Manildo, Matteo; Martini, S.; Genovesi, Corrado; Premoli, A; Fraire, Flavio; Neri, Loris; Mandrino, Silvia; Ferrero, Marcella; Rota, Eugenia

doi:10.1007/s10072-022-06153-1

Cited by 3 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thereby, a high prevalence of infection with H. pylori in patients with headache/migraine is indicated. These results are in agreement with the findings of Cavestro et al, who conducted an impressive cross-sectional study on the relationship between H. pylori infection and headache and found a significant association between these two entities ( p = 0.009) [ 39 ]. Moreover, in their case-control study, Yiannopoulou et al presumed the same association and found that H. pylori infection prevalence was significantly higher in 49 patients with headache than in 51 control subjects ( p = 0.016) [ 40 ].…”

Section: Discussionsupporting

confidence: 92%

Helicobacter pylori Infection in Children: A Possible Reason for Headache?

et al. 2023

View full text Add to dashboard Cite

(1) Background: The correlation between infection with Helicobacter pylori (H. pylori) and headache has been argued and explored for a long time, but a clear association between the simultaneous presence of the two in children has not been established yet. In this study, we aimed to explore this relationship in children from the Northeast region of Romania. (2) Methods: A retrospective study exploring the correlation between children having H. pylori infection and headache or migraine was conducted on a batch of 1757 children, hospitalized over 3 years in a pediatric gastroenterology department in Northeast Romania. (3) Results: A total of 130 children of both sexes had headache. From 130 children, 54 children (41.5%) also presented H. pylori infection. A significant association between headache and H. pylori infection (χ2; p < 0.01) was noticed. (4) Conclusions: More studies are needed on this relationship, and we emphasize the importance of further analyses, as they present great clinical importance for both prompt diagnosis and treatment.

show abstract

Section: Discussionsupporting

confidence: 92%

Helicobacter pylori Infection in Children: A Possible Reason for Headache?

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Among the screened articles, 12 observational studies 8,[11][12][13][14][15][16][17][25][26][27][28] in which the prevalence of H. pylori infection was compared between migraine patients and the control groups were included in the metaanalysis (Table 2), and in total, 493,794 people were evaluated in these 12 studies. In three of these articles, 12,26,28 the rate of H. pylori infection among migraineurs was reported separately between groups with and without aura, which is why each one of them was included in the meta-analysis as two separate studies.…”

Section: Main Analysismentioning

confidence: 99%

“…Hence, the studies that had participated in the metaanalysis were categorized based on their quality (low and high), geographic regions in which the studies were conducted (Africa, Asia, and Europe), the publication time (before 2011 and after 2011), the status of aura in evaluated migraineurs (with aura, without aura, and with and without aura), type of study (case-control, crosssectional, and prospective cohort), and method of H. pylori detection (H. pylori stool antigen, anti-H. pylori serum antibody, urea breath test, endoscopic gastric biopsy, and using the data of a biobank). It is worth noting that in three studies, 12,17,27 more than one diagnostic method were employed for H. pylori detection, and this particular scenario was duly considered during the analyses conducted by meticulously scrutinizing the texts, tables, and figures of the aforementioned studies.…”

Section: Subgroup Analysismentioning

confidence: 99%

“…In eight of the reviewed studies, 11,12,17,18,[26][27][28]31 there were reports on the impact of H. pylori infection on the characteristics of migraine headaches (including duration of headaches, the severity of headaches, and frequency of attacks). Despite differences in assessment methods, the final results of the majority of these studies (five out of eight) are consistent with each other and indicate that there is no difference in the symptoms and characteristics of migraine in H.…”

Section: H Pylori Infection and Migraine Headache Characteristicsmentioning

confidence: 99%

“…Additionally, since 2014, many new original studies have been added to the literature in the field of examining the association between H. pylori infection and migraine headaches. [10][11][12][13][14][15][16][17][18] Therefore, this systematic review and meta-analysis-of all conducted original peer-reviewed studies up to May 2023-was performed to analyze all aspects of the relationship between H. pylori infection and migraine headaches comprehensively and completely (quantitatively and qualitatively), in order to obtain a correct conclusion, which can help clinicians to perform better healthcare for migraine patients. Also, we aimed to clarify the research needs in this regard by identifying the information gaps.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Helicobacter pylori with migraine headaches and the effects of this infection and its eradication on the migraine characteristics in adults: A comprehensive systematic review and meta‐analysis

Bawand,

Ghiasian,

Samadyan

et al. 2023

Helicobacter

View full text Add to dashboard Cite

BackgroundMigraine is one of the most common neurological disorders that can severely overshadow people's quality of life, and Helicobacter pylori infection is a health problem in different societies. During the last two decades, many original studies have been conducted on the various aspects of the relationship between these two disorders; however, they have reported different and sometimes contradictory results.MethodsThis study was conducted based on the PRISMA protocol. We performed a comprehensive literature search in the online databases up to May 2023, and 22 studies that contained original data on the relationship between H. pylori infection and migraine headaches in adults were included. For performing the meta‐analysis, we calculated the odds ratios (OR) and 95% confidence intervals (CI), using a random‐effects model, and to determine the possible causes of heterogeneity, we conducted a subgroup meta‐analysis.ResultsThe overall OR for the association of H. pylori infection and migraine headaches through 493,794 evaluated individuals was 2.80 [95% CI = 1.75–4.48; I2 = 89.20, p < 0.01], which reveals a statistically significant association between these disorders. It was found that the studies that were conducted in Asian regions and the recently published ones have clearly shown a higher association between migraine and H. pylori infection. On the other hand, migraine patients who are infected with H. pylori have similar signs and symptoms as H. pylori‐negative migraineurs; meanwhile, the clinical trials conducted in this field strongly emphasize the benefits of eradicating H. pylori infection in migraine patients and have estimated its effectiveness in improving migraine headaches equivalent to current common migraine treatments. Furthermore, it was reported that white matter lesions were 2.5‐fold higher on brain MRI in patients with H. pylori‐positive migraine compared with H. pylori‐negative migraineurs; however, the evidence does not support the role of oxidative stress in patients suffering from H. pylori infection and migraine and refuses the role of Cag‐A‐positive strains of H. pylori in migraine headaches.ConclusionAccording to the currently available data, it seem reasonable that patients with a definite diagnosis of migraine who also suffer from gastrointestinal problems, undergo the H. pylori detection tests and if the evaluations are positive, H. pylori eradication treatment can be considered even before any migraine treatment.

show abstract

Comparison of multiple treatment regimens in children with Helicobacter pylori infection: A network meta-analysis

Liang

Zhu²,

Zhao³

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundMultiple regimens have been widely used in the eradication treatment of Helicobacter pylori infection in children. However, there is a lack of comparison and evaluation of their effectiveness in different regions of the world.MethodsRandomized controlled trials were retrieved. Review Manager 5.4, Stata SE 15 and R 4.0.4 statistical software were used to analyze date. The ranking probability is assessed according to the surfaces under cumulative ranking (SUCRA).Results163 studies were eligible for this study, involving 336 arms and 18,257 children, and 10 different interventions. The results showed that the eradication rates of sequential therapy with probiotics (SP), bismuth-containing quadruple (Quadruple) therapy, concomitant therapy and PCN therapy were at least 90%. Cumulative ranking showed that SP therapy had the best eradication effect (SUCRA 92.7%) whereas Bismuth-containing triple therapy (B) had the worst (SUCRA 3.5%). Subgroup analysis suggested that SP therapy ranked first in China and other regions, and the ranking of Triple therapy with probiotics therapy (TP) was equally stable (SUCRA 72.0% vs 76.4% respectively). The security of the SP and TP therapy had great advantages.ConclusionsAs for the eradication treatment of Helicobacter pylori infection in children, SP therapy ranks highest. SP and TP therapies are most safe.

show abstract

A cross-sectional study on the association between Helicobacter pylori infection and headache

Cited by 3 publications

References 25 publications

Helicobacter pylori Infection in Children: A Possible Reason for Headache?

Helicobacter pylori Infection in Children: A Possible Reason for Headache?

Association of Helicobacter pylori with migraine headaches and the effects of this infection and its eradication on the migraine characteristics in adults: A comprehensive systematic review and meta‐analysis

Comparison of multiple treatment regimens in children with Helicobacter pylori infection: A network meta-analysis

Contact Info

Product

Resources

About