A cross-sectional study on the relationships among the polymorphism of period2 gene, work stress, and insomnia

Ju, Li; Huang, Chan; Lan, Yajia; Wang, Yongwei

doi:10.1007/s11325-015-1229-4

Cited by 17 publications

(11 citation statements)

References 40 publications

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“…For instance, a significant association between Per3 and insomnia was described by Brower and coworkers (2012) [22]. Similar findings were found when period 2 gene (Per2) was associated with insomnia [23]. Another gene candidate related to insomnia has been the serotonin transporter polymorphic region (5-HTTLPR), adenosine, GABA and orexin/hypocretin [18].…”

Section: Genes and Insomniasupporting

confidence: 56%

The End of Snoring? Application of CRISPR/Cas9 Genome Editing for Sleep Disorders

et al. 2017

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Section: Genes and Insomniasupporting

confidence: 56%

The End of Snoring? Application of CRISPR/Cas9 Genome Editing for Sleep Disorders

et al. 2017

View full text Add to dashboard Cite

“…Although not explicitly focused on insomnia, several of the first studies examined the role of circadian genes ( CLOCK , Timeless ) and sleep in individuals with mood disorders, with mixed results [43,44,45]. More recent work has been in the Per genes, with a Chinese study finding a significant association between Per2 genotype and insomnia, as well as a G×E interaction with Per2 , work stress, and insomnia [46]. Another paper, examining Per3 and insomnia in individuals with alcohol dependence, also found a significant genotype effect [47].…”

Section: Measured Gene Studies Of Insomniamentioning

confidence: 99%

Genetic Pathways to Insomnia

Lind

Gehrman

2016

Brain Sciences

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This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a discussion of the insomnia genetics literature with regard to each of the following common methodologies: twin and family studies, candidate gene studies, and genome-wide association studies (GWAS). Next, we summarize the most recent gene identification efforts (primarily GWAS results) and propose several potential mechanisms through which identified genes may contribute to the disorder. Finally, we discuss new genetic approaches and how these may prove useful for insomnia, proposing an agenda for future insomnia genetics research.

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“…Furthermore, researchers examined the main effects of genetic factors on sleep, but they had incongruent outcomes (Barclay, Eley, Mill, et al, 2011; van Dalfsen & Markus, 2019; Huang et al., 2014). More interestingly, recent studies showed interactions between serotonin transporter‐gene‐linked polymorphic region ( 5‐HTTLPR ), CLOCK , period 3 ( PER3 ), and PER2 gene polymorphisms and stress on sleep (Antypa et al, 2012; Huang et al., 2014; Li, Huang, Lan, & Wang, 2015). This kind of gene–environment interaction has been suggested to be able to produce robust genetic results, as it focussed on homogenous environmental subsets and thus reduced the aetiological heterogeneity (Wray et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

Association of job stress, CLOCK gene polymorphism and their interaction with poor sleep quality

Cao

et al. 2020

Journal of Sleep Research

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Job stress and the Circadian Locomotor Output Cycles Kaput (CLOCK) gene could affect circadian rhythm and sleep quality. The main aim of our present study was to investigate the association of job stress, CLOCK gene polymorphism and their interaction with sleep quality in a non‐clinical Chinese Han population, which has not been reported to date. Using a cross‐sectional design, 450 subjects were recruited in Beijing. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and job stress was measured with the Work Stress Scale. CLOCK gene rs11932595 polymorphism was genotyped in 297 blood samples. Correlation analysis showed a close but different association of high job stress with the PSQI and its components. Analysis of variance showed significant main effects of the CLOCK gene rs11932595 polymorphism. G‐allele carriers had a higher score in the PSQI, sleep duration, sleep latency and sleep disturbances. Further interaction analyses showed an ordinal interaction on sleep duration, and a disordinal interaction on daytime dysfunction. Specifically, G‐allele carriers had poorer sleep duration than AA homozygotes when in high job stress, while the two subgroups displayed similar sleep duration when in low job stress, conforming to the diathesis–stress model. In comparison to G‐allele carriers, AA homozygotes experienced less daytime dysfunction when in low job stress whereas more daytime dysfunction when in high job stress, fitting with the differential susceptibility model. As genetic links have been revealed, our investigation might be conducive for elucidating aetiological factors for sleep quality and targets for implementing interventions to attain good sleep quality.

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A cross-sectional study on the relationships among the polymorphism of period2 gene, work stress, and insomnia

Abstract: The effect of genotype AC or allele C of Per2 on insomnia was relatively stronger than that of high work stress, suggesting that individual's susceptibility should be taken into consideration when intervening and controlling insomnia of workers.

Cited by 17 publications

References 40 publications

The End of Snoring? Application of CRISPR/Cas9 Genome Editing for Sleep Disorders

The End of Snoring? Application of CRISPR/Cas9 Genome Editing for Sleep Disorders

Genetic Pathways to Insomnia

Association of job stress, CLOCK gene polymorphism and their interaction with poor sleep quality

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