A Cross-Sectional Study Regarding Infertility Among Women in Iraq

Hussam, Fadhil; Khudair, Shaymaa Abdulhameed; Alkhafaje, Waleed K.; Alnassar, Yasir S.; Kaoud, Rashad M.; Abed, Ahmed Najm; Jabbar, Haneen Saad; Numan, Hiba Ali

doi:10.30699/jogcr.8.1.47

Cited by 4 publications

(1 citation statement)

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“…The sample size was calculated with this equation; (N = p (1-p)z2/me2), where P is the prevalence rate of infertile women (12%) according to a previous study [7], Z = 1.96, Me = 0.05. The sample size was 162.…”

Section: Methodsmentioning

confidence: 99%

Is There a Correlation Between Serum SFRP5 and Wnt5a Proteins and Insulin Resistance in Iraqi Infertile Females Undergoing ICSI?

Mohsin,

Jwad,

Lafta

2023

amj

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Background: Secreted frizzled-related protein 5 (SFRP5) is an adipokine that inhibits the noncanonical Wingless Type (Wnt) signalling pathway. It may have anti-inflammatory and insulin-sensitizing effects, but the evidence is conflicting.Objectives: This study examined the influence of serum and follicular fluid levels of SFRP5 and Wnt5a on intracytoplasmic sperm injection (ICSI) outcomes in infertile women, considering their relationship to insulin sensitivity. Materials and methods: Ninety infertile women aged 18 to 45 years undergoing ICSI for various reasons were enrolled in this prospective cross-sectional study at the infertility centre of the

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Section: Methodsmentioning

confidence: 99%

Is There a Correlation Between Serum SFRP5 and Wnt5a Proteins and Insulin Resistance in Iraqi Infertile Females Undergoing ICSI?

Mohsin,

Jwad,

Lafta

2023

amj

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The Impact of Serum and Follicular Fluid Irisin on Oocyte and Embryonic Characteristics in Infertile Women Undergoing ICSI According to BMI

Dawood,

Jwad,

Mossa

2023

Al-Rafidain J Med Sci

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Background: Irisin is a recently identified myokine that acts like adipokines. It has been revealed to be connected with insulin resistance (IR), obesity, and metabolic syndrome. Objective: To investigate serum, follicular fluid (FF), irisin, and IR in lean, overweight, and obese women undergoing the intracytoplasmic sperm injection (ICSI) cycle and correlate them with oocyte and embryo quality. Methods: Ninety infertile Iraqi women aged 18 to 40 years had primary or secondary infertility. They were enrolled in this study and divided into three groups according to body mass index ranking: the first group: twenty-seven normal-weight females, the second group: thirty-five overweight females, and the third group: twenty-eight obese females. ICSI was done for them to evaluate the level of serum and follicular fluid Irisin with the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) at the day of oocyte pickup and correlate them to the outcome. Results: HOMI-IR, serum, and FF Irisin levels were significantly higher in obese people. Also, there was a significant difference between groups in regard to MII, oocyte maturity rate, grade 1 embryo, and pregnancy outcome, which was less in the obese group. In addition, there was a significant negative correlation between HOMI-IR and irisin levels in serum and follicular fluid with MII oocyte count, oocyte maturity rate, embryo grade 1, and pregnancy outcome. Conclusion: Serum, follicular fluid Irisin, and HOMA-IR were significantly higher in obese cases than in lean cases, which may cause a reduction in the ICSI outcome.

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TNF-alpha and IL-10 Levels in Iraqi PCOS and Non-PCOS Patients Undergoing ICSI: An Immunological Perspective

Albayati,

Abdulhameed

2024

Al-Rafidain J Med Sci

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Background: Essential cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) play a critical role in immune regulation, particularly in conditions like polycystic ovary syndrome (PCOS). Objective: To compare TNF-α and IL-10 levels in patients with and without PCOS undergoing intracytoplasmic sperm injection (ICSI) and their effects on ICSI. outcome Methods: This study involved a cohort of 125 patients undergoing ICSI, divided into two groups: those identified with PCOS according to Rotterdam criteria (n=65) and those without PCOS (n=60). The ELIZA method was used to measure the levels of TNF-α and IL-10 in the blood in order to see if they were related to PCOS and to look into a possible connection between these cytokines and the outcome of the ICSI. Results: Significant differences were found in the serum levels of TNF-α and IL-10 between the two groups, suggesting a distinct immunological profile in PCOS patients undergoing fertility treatment. There is no significant correlation between these cytokines and the total number of retrieved oocytes, oocyte maturity, fertilization rate, or pregnancy rate. Conclusions: The study revealed notable differences in serum TNF-α and IL-10 levels between PCOS and non-PCOS groups, suggesting a unique immunological profile in PCOS patients undergoing fertility treatments. Both cytokines did not significantly correlate with the total number of retrieved oocytes, oocyte maturity, fertilization rate, or pregnancy rate. Other factors might be more influential in determining crucial fertility outcomes.

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A Cross-Sectional Study Regarding Infertility Among Women in Iraq

Cited by 4 publications

References 0 publications

Is There a Correlation Between Serum SFRP5 and Wnt5a Proteins and Insulin Resistance in Iraqi Infertile Females Undergoing ICSI?

Is There a Correlation Between Serum SFRP5 and Wnt5a Proteins and Insulin Resistance in Iraqi Infertile Females Undergoing ICSI?

The Impact of Serum and Follicular Fluid Irisin on Oocyte and Embryonic Characteristics in Infertile Women Undergoing ICSI According to BMI

TNF-alpha and IL-10 Levels in Iraqi PCOS and Non-PCOS Patients Undergoing ICSI: An Immunological Perspective

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