A cross-sectional study to assess the rationality of fixed dose combinations prescribed in geriatric patients in a tertiary care hospital

Dakappa, Ahish; Narayanareddy, Mukunda

doi:10.18203/2319-2003.ijbcp20162450

Cited by 1 publication

(3 citation statements)

References 7 publications

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“…In contrast, a study among geriatric patients (58.7%) and pharmacy stores of Ahmedabad, India (54.4%), showed high FDCs use in male. 10,13 Generally, adult age groups are considered healthier; however, FDCs were found to prescribe more to adults aged 21 to 40 years in our study. Similarly, a study of Ahmedabad, India showed high number of FDCs prescribed to 31 to 49-year patients (23.7%).…”

Section: Discussionmentioning

confidence: 48%

“…According to WHO, FDCs are rational when the combination has a proven advantage over single compounds administered separately in therapeutic effect, safety, and adherence or in delaying the development of drug resistance. 10 The combination should act by different mechanism and act as a booster for another. 18 However, 6.81% of FDCs (n=3) that are paracetamol 500 mg and ibuprofen 400 mg tablet, paracetamol 125 mg and ibuprofen 100 mg per 5 ml, and ampicillin 250 mg and cloxacillin 250 mg capsule have a different mechanism of action and no complementary action.…”

Section: Discussionmentioning

confidence: 99%

“…The instrument for the study was prepared by reviewing the literature and consultation with senior colleagues. 6,7,10 The designed questionnaire collects demographics (age, gender), FDCs name (brand or generic name), FDC composition and total FDC prescribed. The EML list of Nepal 2016 and World Health Organisation (WHO) 2017 were used for study.…”

Section: Methodsmentioning

confidence: 99%

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An evaluation of fixed dose combinations and it’s practices at medicine department of tertiary care hospital, Nepal

Shrestha

Gurung²

2020

Int J Sci Rep

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Background: A large proportion of fixed dose combinations (FDCs) are manufactured and used widely in Nepal. This study aimed to evaluate the FDCs and its utilization in medicine department of tertiary care hospital.Methods: A cross-sectional study was conducted for 50 days among admitted patients in the medicine department of tertiary care hospital, Nepal. A predesigned form was used to collect the data at the time of patient discharge. Only the oral FDCs were selected for study. Microsoft Excel 2007 was used for statistical analysis and data were presented as number and percentage in tabulated and figure forms. Results: Oral FDCs were used in 27.08% of admitted patients. A total of 295 FDCs were prescribed in 208 patients with 44 FDC items in 58 different brand names. Categorically, the most commonly used FDCs were of analgesics (34.24%) followed by antibiotics (25.76%) and vitamin supplements (22.71%). The 27.27% of FDCs prescribed contain more than two active pharmaceutical ingredients (APIs) up to nine and the highest number of APIs were found in vitamin supplements. All FDCs were prescribed in the brand names. The very few 2.27% and 4.55% of FDCs were prescribed from the essential medicine list of Nepal and world health organization, respectively.Conclusions: The use of FDCs listed in essential medicine list was very poor. Similarly, generic prescribing was also zero. The regulatory body must study the rationality of FDC before production, marketing, importing, and utilization in hospital.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%