A Cross-Sectional Study to Detect the Prevalence of Hyperhomocysteinemia in Cases of Deep Vein Thrombosis

Abstract

Hyperhomocysteinemia is a known risk factor for the development of deep vein thrombosis (DVT). Various studies have been conducted in the western countries to know the prevalence of hyperhomocysteinemia in patients with DVT and in general population. There is no documented literature of the prevalence of hyperhomocysteinemia in Indian population. Thus the aim of this study was to determine the prevalence of hyperhomocysteinemia in cases of DVT in our population. To evaluate the prevalence of hyperhomocysteinemia, a prospective cross sectional study done on a total of 70 patients admitted in KLES Dr Prabhakar Kore hospital, Belgaum, India. DVT was confirmed by Doppler examination. Serum homocysteine was measured and the data analysed. Statistical significance was calculated using chi square test. A total of 70 patients were studied of which 53 were males and 17 were females. The prevalence of hyperhomocysteinemia among the cases of DVT was 31.428%.The prevalence among males was 35.85% and among females was 17.64%.There was statistically significant association between hyperhomocysteinemia and presence of ischaemic heart disease with a p value of 0.005 on chi square analysis. The prevalence of hyperhomocysteinemia in cases of deep vein thrombosis in our population was 31.428%. There was a statistically significant association between hyperhomocysteinemia and ischaemic heart disease.

Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products

“…It is biosynthesized from the amino acid methionine to which it can also be recycled in a process that involves folate and various B-vitamins (B6 and B12). When the upstream or downstream metabolic pathway of HCY is blocked or delayed for various reasons, it leads to the accumulation of HCY, causing hyperhomocysteinaemia which, although causing no symptoms, affects the interior lining of blood vessels, increasing the risk of atherosclerosis (Sun et al 2017); increases the risk of deep vein thrombosis (Kamat et al 2010, Ekim et al 2015 and pulmonary embolism (Cellai et al 2014); may be related to Alzheimer's disease (Sharma and Lipincott 2017) and other types of dementia (Xie et al 2017) and may be associated with pre-eclampsia in pregnancy (Sayyah-Melli et al 2016, Wadhwani et al 2016. Thus, hyperhomocysteinaemia is associated with various diseases, in particular CVD (Olkkonen 2012, Lathe et al 2014.…”

Evaluation of oxidative stress balance in acute deep vein thrombosis

“…in the context of complex interactions between environmental and genetic predisposing factors. In addition, DVT is characterized by small flow velocity and a low shear rate, but a large thrombotic mass is a good model for investigating the role of oxidative stress [22]. In this study, TOS and OSI levels were considerably and significantly higher in the patients with DVT compared to the individuals in the control group (p<0.0001).…”

A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran

“…The important finding of the present study was the prevalence of homozygous MTHFR 677C/T in DVT patients. The polymorphism results in a modest increase in homocysteine in plasma which may have a pathogenic significance in thrombosis 26 27 . Hyperhomocysteinemia may not be a direct cause of thrombosis but a marker of systemic or endothelial stress and platelet activation 28 .…”