A Cross Sectonal Observational Study of Prognostic Value of Veno-Arterial Carbon Dioxide Difference in Septic Shock Patients in ICU

Abstract

Background and Aim: Early identification of tissue hypoperfusion helps in decreasing mortality due to septic shock. This tissue hypoperfusion not only occurs due to decreased perfusion pressures due to hypotension, caused by reduced cardiac output (CO), but also due to the abnormal regional distribution of blood flow.Metabolic variables like central venous oxygen saturation(scvo2), serum lactate are established markers of tissue hypoperfusion. Recently, the central venous-to-arterial carbon dioxide difference (va)CO2 has been proposed as an alternative marker of tissue hypoperfusion.So we deigned this study aiming to know the porognostic value of venous-to-arterial carbon dioxide difference in septic shock. Materials and Methods: Patients ,admitted in ICU,satisfying the criteria of septic shock were studied.Arterial blood gas,central venous samples are obtained, on admission ,6h,12h,24h.sixty patients were studied.Patients were classified into survivors and nonsurvivors. venous-to-arterial carbon dioxide difference difference and serum were evaluated and correlated to outcome.