A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

Livshits, Gregory; Kalinkovich, Alexander

doi:10.1016/j.arr.2023.101852

Cited by 25 publications

(13 citation statements)

References 447 publications

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“…Chronic low-grade inflammation has been widely recognized as a pathogenesis factor in a wide array of highly detrimental pathophysiological conditions such as auto-immune, cancerous, cardiovascular, metabolic, musculoskeletal, neurodegenerative, psychosomatic, reproductive, dermatological, and other disorders [ 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 ]. BP encompasses marked inhibitory activities on inflammations including systemic and localized forms such as neuroinflammation and digestive wall inflammations [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved in the genesis and development of many world-scale public health burdens, such as metabolic and cardiovascular diseases. In recent years, bee pollen is emerging as a scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix is being extensively studied, and has proven to be a very rich and well-balanced nutrient pool. In this work, we reviewed the available evidence on the interest in bee pollen as a nutrient source. We mainly focused on bee pollen richness in nutrients and its possible roles in the main pathophysiological processes that are directly linked to nutritional imbalances. This scoping review analyzed scientific works published in the last four years, focusing on the clearest inferences and perspectives to translate cumulated experimental and preclinical evidence into clinically relevant insights. The promising uses of bee pollen for malnutrition, digestive health, metabolic disorders, and other bioactivities which could be helpful to readjust homeostasis (as it is also true in the case of anti-inflammatory or anti-oxidant needs), as well as the benefits on cardiovascular diseases, were identified. The current knowledge gaps were identified, along with the practical challenges that hinder the establishment and fructification of these uses. A complete data collection made with a major range of botanical species allows more robust clinical information.

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Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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“…Pulmonary limitation could potentially increase the likelihood of systemic inflammation [ 57 ]. However, chronic inflammation governs the development of age-associated sarcopenia [ 58 ]. In patients with COPD, handgrip strength and skeletal muscle mass index were correlated with IL-6 and TNF [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Cognition as mediator of pulmonary function and risk of sarcopenia among older adults

Hu,

Tang,

Zhan

2024

BMC Public Health

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Background The relationship between lung function and sarcopenia remains ambiguous. The primary aim of this study was to investigate the potential association between lung function and sarcopenia in the older adults, as well as to examine the mediating role of cognitive function in this relationship. Methods The participants were selected from a nationally representative population-based cohort in China. The peak expiratory flow (PEF) measurement was used to evaluate the lung function in older persons. The sarcopenia was diagnosed using the guidelines of the Asian Working Group for Sarcopenia (AWGS) in 2019. The Cox proportional hazard model was utilized to perform primary analyses of the relationship between PEF and sarcopenia. The mediating effect of cognitive function was evaluated using the counterfactual mediation method. Results This cohort study included 4,011 older adults (average age, 66.6 years; 53.3% males). During a follow-up period of 3.86 years, 349 individuals were diagnosed with sarcopenia. After adjusting for potential confounders, each one-standard-deviation increase in PEF was associated with a 28% reduction in the risk of sarcopenia (hazard ratio [HR]: 0.72; 95% confidence interval [CI]: 0.63, 0.80). There was a significant mediation of cognition for the association between PEF and incident sarcopenia, and the proportion mediated was 12.2% (95% CI: 4.5%, 23.1%). Conclusions Older adults with impaired lung function are more likely to develop sarcopenia. Nevertheless, cognition can explain only a small portion of this association. Thus, other potential pathways between lung function and sarcopenia must be elucidated.

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“…It is essential to consider that obesity and aging are two leading factors fulling the chronic inflammatory process [11]. Therefore, we performed an exploratory analysis, excluding patients (with BMI greater than 40 and those older than 70); in the remainder, there was a greater reduction of pro-inflammatory cytokines among the patients receiving vitD (P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D

Silva

Inserra

Mariani

et al. 2023

Exploration of Medicine

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Aim: To evaluate angiotensin II (Ang II) and Ang-(1-7) levels and the cytokine profile in patients hospitalized with mild coronavirus disease 2019 (COVID-19) and contrast them with patients with identical clinical conditions but treated with high doses of vitamin D (vitD). Methods: From the 218 patients recruited (ClinicalTrials.gov NCT04411446), 16 participated in this sub-study and were randomized to a single oral dose of 500,000 IU vitD (n = 10) or placebo (n = 6). Plasmatic Ang II and Ang-(1-7) levels were determined by radioimmunoassay and interleukins (ILs) 1, 6, 8, and 10 and tumor necrosis factor alpha (TNF-α) by enzyme-linked immunosorbent assay before and after treatment. Parallel, serum 25-hydroxyvitamin D3 (25-OH vitD) concentrations as vitD status was measured by a chemiluminescence immunoassay. Results: A trend towards an increase in Ang-(1-7) and a decrease in Ang II levels were observed in placebo- and vitD-treated COVID-19 patients compared to baseline values. There was no difference in Ang II and Ang-(1-7) levels between placebo- and vitD-treated COVID-19 patients. Similar results were obtained with ILs profile. COVID-19 patients showed an increase in the protective component of the RAS which was not improved by vitD treatment. Conclusions: VitD did not improve RAS disbalance in COVID-19. Notwithstanding, the authors visualize that acute treatment with high doses of vitD may show a trend to a decline in inflammatory ILs and an increase in protective markers. Finally, the authors would like to highlight the limitations of this preliminary study, namely the small number of patients and the use of a large single bolus dose of vitD rather than lower daily doses for extended periods with prolonged follow-up times. All these factors need special consideration in the designs of new vitD supplementation trials. All these factors need special consideration in the designs of new vitD supplementation trials (ClinicalTrials.gov identifier: NCT04411446).

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A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

Cited by 25 publications

References 447 publications

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Cognition as mediator of pulmonary function and risk of sarcopenia among older adults

Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D

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