A network is often an obvious choice for modeling real-life interconnected systems, where the nodes represent interacting objects and the edges represent their associations. There has been immense progress in complex network analysis with methods and tools that can provide important insights into the respective scenario. In the advancement of information technology and globalization, the amount of data is increasing day by day, and it is indeed incomprehensible without the help of network science. This work highlights how we can model multiple interaction scenarios under a single umbrella to uncover novel insights. We show that a varying scenario gets reflected by the change of topological patterns in interaction networks. We construct multi-scenario graphs, a novel framework proposed by us, from real-life environments followed by topological analysis. We focus on two different application areas: analyzing geographical variations in SARS-CoV-2 and studying topic similarity in citation patterns.