A crossover clinical study to evaluate pain intensity from microneedle insertion in different parts of the oral cavity

Santos, Stephany Di Carla; Fávaro-Moreira, Nadia Cristina; Abdalla, Henrique Ballassini; Augusto, Gabriela Gama Xavier; Costa, Yuri Martins; Volpato, Maria Cristina; Groppo, Francisco Carlos; Gill, Harvinder Singh; Franz-Montan, Michelle

doi:10.1016/j.ijpharm.2020.120050

Cited by 23 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As reported, the human skin displays a viscoelastic behavior which provides an idea of the elasticity of human's skin which can be hypothesized as a function of the thickness of its layer, [ 41 ] where the stiffness decreases with aging due to the loss of the dermal layer as a result of increase in fat infiltration into the skin. [ 42,43 ] Pain evaluation for targeted sites slightly changes in various oral cavities, [ 44 ] sensitive to pain in forehead, forearm, and less in abdomen skin with a dependence on physical parameters of MN [ 45 ] and when used at common injection location, especially during facial procedures where patients pain threshold, depth and differences in skin structures at those locations are taken into account. [ 35 ]…”

Section: Resultsmentioning

confidence: 99%

ML‐Augmented Bayesian Optimization of Pain Induced by Microneedles

Abdullah,

Tasoglu

2024

Advanced Sensor Research

View full text Add to dashboard Cite

Microneedles (MNs) have emerged as a promising solution for drug delivery and extraction of body fluids. Pain is an important physiological attribute to be examined when designing MNs. There is no known representation of pain with geometric features of a MN despite the focus on experimental work. This study focuses on optimizing MN designs with the aim of minimizing pain through means of machine learning, finite element analysis, and optimization tools. Three distinct approaches are proposed. The first approach involves training multiple regression models on data obtained through finite element analysis in COMSOL. The second approach uses COMSOL's built‐in nonlinear optimization solver. Finally, the third approach utilizes the LiveLink interface between COMSOL and MATLAB, combined with Bayesian optimization. Each approach presents unique strengths and challenges, with the third approach demonstrating significant promise due to its efficiency, practicality, and time‐saving.

show abstract

Section: Resultsmentioning

confidence: 99%

ML‐Augmented Bayesian Optimization of Pain Induced by Microneedles

Abdullah,

Tasoglu

2024

Advanced Sensor Research

View full text Add to dashboard Cite

show abstract

“…This technique can not only avoid the high blood concentrations caused by intravenous drug administration and the "first pass effect" of oral drug administration, but also further promotes drugs to enter the blood circulation and maximizes the drugs' effects. Some studies have found that microneedles cause less pain in the oral mucosa than 30 G hypodermic syringes applied to different parts of the oral cavity 29) . In addition, microneedles applied to soft tissues of the skin can directly enter the keratinized layer to the connective tissue layer, forming microinjuries that can produce slight bleeding, stimulating the body to immediately initiate a wound healing cascade response, activating the release of various growth factors such as PDGF, EGF, TGF, FGF, etc.…”

Section: Discussionmentioning

confidence: 99%

Topical Application of Microneedling and a Hyaluronic Acid Gel Promotes Periodontal Soft Tissue Regeneration <i>in Vivo </i>

Liu

Ren

et al. 2023

J. Hard Tissue Biology.

View full text Add to dashboard Cite

The aim of this study was to evaluate the effects of microneedling (MN) combined with an injectable hyaluronic acid (HA) gel on soft tissue regeneration in a rat gingival recession model. In this split-mouth study, seven Sprague-Dawley rats with artificially created gingival recession areas were randomized for treatment with MN+HA or HA. HA was injected in the gingival recession area of the right maxillary molar and MN+HA was performed in the gingival recession area of the left maxillary molar of rats, both 3 times, 7 days apart. At 2 weeks after the last treatment, each rat was euthanized and the surgical areas, including the maxillary first molar and periodontal tissue, were excised and evaluated by stereomicroscopy, histochemistry and enzyme-linked immunosorbent assay. Physical parameters representing periodontal soft tissue regeneration, including the vertical distance from the lowest point of the gingival margin to the crown margin along the long axis of the tooth, the gingival height and the gingival thickness, were significantly improved in the MN+HA group compared with the HA group. The MN+HA group showed a significant increase in the expression of Type 1 collagen compared with the HA group. Thus, this study demonstrates for the first time that the application of MN combined with a HA gel, a nonsurgical therapy, in a rat animal model of gingival recession improves the degree of gingival recession, increases gingival thickness and promotes periodontal soft tissue regeneration. Secondly, the effect of MN combined with the HA gel injection to promote periodontal soft tissue regeneration was significantly better than the HA gel injection alone, which suggests that the participation of MN effectively promotes periodontal soft tissue regeneration.

show abstract

“…[ 145 ] Although there is no significant difference in pain caused by microneedle insertion in the different parts of the mouth, the pain increases gradually from the cheeks, palate, tongue, and gums to the lips. [ 143 ] Many types of oral diseases are associated with different characteristics, hence, appropriate drugs and drug delivery sites should be selected according to the characteristics of the disease type. In the next section, we present a review of the application of microneedles in oral mucosal diseases, periodontal diseases, oral cancer, and other diseases (Table 3).…”

Section: Hydrogel Microneedles In Dentistrymentioning

confidence: 99%

Application of hydrogel microneedles in the oral cavity

He,

Fan

et al. 2024

Biopolymers

View full text Add to dashboard Cite

Microneedles are a transdermal drug delivery system in which the needle punctures the epithelium to deliver the drug directly to deep tissues, thus avoiding the influence of the first‐pass effect of the gastrointestinal tract and minimizing the likelihood of pain induction. Hydrogel microneedles are microneedles prepared from hydrogels that have good biocompatibility, controllable mechanical properties, and controllable drug release and can be modified to achieve environmental control of drug release in vivo. The large epithelial tissue in the oral cavity is an ideal site for drug delivery via microneedles. Hydrogel microneedles can overcome mucosal hindrances to delivering drugs to deep tissues; this prevents humidity and a highly dynamic environment in the oral cavity from influencing the efficacy of the drugs and enables them to obtain better therapeutic effects. This article analyzes the materials and advantages of common hydrogel microneedles and reviews the application of hydrogel microneedles in the oral cavity.

show abstract

A crossover clinical study to evaluate pain intensity from microneedle insertion in different parts of the oral cavity

Cited by 23 publications

References 30 publications

ML‐Augmented Bayesian Optimization of Pain Induced by Microneedles

ML‐Augmented Bayesian Optimization of Pain Induced by Microneedles

Topical Application of Microneedling and a Hyaluronic Acid Gel Promotes Periodontal Soft Tissue Regeneration <i>in Vivo </i>

Application of hydrogel microneedles in the oral cavity

Contact Info

Product

Resources

About