A Crown Ether Appended Super Gelator with Multiple Stimulus Responsiveness

Dong, Shengyi; Zheng, Bo; Xu, Duanfu; Yan, Xuzhou; Zhang, Mingming; Huang, Feihe

doi:10.1002/adma.201200837

Cited by 258 publications

(110 citation statements)

References 49 publications

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“…47 Moreover, in diethylene glycol (DEG), Fmoc-F behaves as a common low molecular weight gelator (LMWG), presenting a CGC of 1 wt% (Table S1, ESI ‡). Transparent hydrogels ( Fig.…”

Section: Gelating Ability and Study Of Gel Propertiesmentioning

confidence: 99%

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

et al. 2017

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show that f-HNT functions only as an additive in the hybrid gels and does not demonstrate gelator behavior. The in vitro kinetic release from both f-HNT/CPT and Fmoc-F/f-HNT/CPT was studied in media that imitates physiological conditions, and the factors controlling the release process were determined and discussed. Furthermore, the antiproliferative in vitro activities of the gels were evaluated towards human cervical cancer HeLa cells. A comparison of data collected in both systems shows the synergistic action of f-HNT and the gel matrix in controlling the release of CPT in the media and maintaining the drug in its active form. Finally, a comparison with pristine HNT is also reported. This study suggests a suitable strategy to obtain two-component gel hybrids based on nanocarriers with controlled drug carrier capacity for biomedical applications.

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“…47 Moreover, in diethylene glycol (DEG), Fmoc-F behaves as a common low molecular weight gelator (LMWG), presenting a CGC of 1 wt% (Table S1, ESI ‡). Transparent hydrogels ( Fig.…”

Section: Gelating Ability and Study Of Gel Propertiesmentioning

confidence: 99%

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

et al. 2017

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“…Subsequently, the same authors reported another example of a supramolecular polymeric gel based on host-guest interactions. [42] Gelator 11 was designed by introduction of a dibenzo-24-crown-8 (DB24C8) crown ether moiety, which acts as the host, and an organic ammonium salt unit, the guest, to a long flexible alkyl chain. The gelator was found to gel a class of organic solvents with a relatively low CGC, and thus falls into the category of supergelators.…”

Section: Mrsgs Based On Host-guest Interactionsmentioning

confidence: 99%

Multistimuli‐Responsive Supramolecular Gels: Design Rationale, Recent Advances, and Perspectives

Sun

Huang

et al. 2014

ChemPhysChem

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This manuscript presents a brief overview of recent advances in multistimuli-responsive supramolecular gels (MRSGs). The synthesis of MRSGs with faster and smarter responsive abilities to a variety of external stimuli, such as redox reagents, pH changes, ligands, and coupling reagents, is one key issue for the upgrade of current molecular motors, signal sensors, shape memory devices, drug delivery systems, display devices, and other devices. However, the design rules of MRSGs are still not well understood. The lack of information about the relationship between the spatial structure and gelation behavior of existing gelators means that the knowledge required to design new gelators by the addition of functional moieties to well-known gelators is lacking. Insights into the gelation pathway of known gelators may bring inspiration to researchers who want to exploit elegant designs and specific building blocks to obtain their own MRSGs with predictable stimuli-responsive abilities.

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“…其中, 稀土纳米晶因其独特的 4f 电子能级结构与丰富的能量转换模式, 在高质量发光体、上转换发光材料、生物荧光探测与标记等领域具有重要的应用前景 [7～9] . 以聚异丙基丙烯酰胺(PNIPAm)为代表的温敏聚合物及其水凝胶是一种典型的环境敏感型智能新材料, 因其在药物分离以及生物工程、化学传感及形状记忆等方面的潜在应用受到广泛关注 [10,11] . 近年来, 将荧光纳米晶与智能聚合物进行复合, 制备具有荧 DOI: 10.6023/A12070417 光温敏特性的功能性复合凝胶, 正成为纳米复合新材料研究中的前沿课题 [12～15] .…”

Section: 引言unclassified

Thermosensitive Fluorescent Behavior and Mechanism of EuF₃-NaYF₄Nanocrystals/PNIPAm Ternary Complex Hydrogel

Song¹,

Kang²,

Yao³

et al. 2012

Acta Chim. Sinica

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In this work, EuF 3 and NaYF 4 nanocrystals were prepared by liquid-solution-solid (LSS) method respectively, high-resolution transmission electron microscopy (HRTEM) images revealed that the as-prepared NaYF 4 nanocrystals were monodisperse nanoparticles with the size about 30 nm; while the as-prepared EuF 3 were polydisperse nanoparticles with the size of 5～20 nm. And they were used to prepare a series of novel ternary complex hydrogels of EuF 3 -NaYF 4 nanocrystals/poly(N-isopropyl acrylamide) (PNIPAm) by free radical polymerization. In a typical synthesis, 2 mg the as-prepared EuF 3 and NaYF 4 nanocrystals, 201.6 mg reactants of N-isopropyl acrylamide (NIPAm), N,N'-methylenebisacrylamide (BIS) and azodiisobutyronitrile (AIBN) (m NIPAm ∶m BIS ∶m AIBN ＝200/0.2/1.4) and 4 mL CHCl 3 were mixed and added into a 10 mL sealing tube. The tube was placed into an ultrasonic oscillator for about 10 min to obtain a uniform mixture, and then oxygen was removed by bubbling N 2 and successfully exerting vacuum on the tube for about 5 min. After the operation was repeated three times, the tube was sealed and kept at 60 ℃ for 3 h. After that, the crude complex hydrogels were synthesized. Finally, the crude hydrogels were immersed into deionized water to remove the remained monomers and impurities. The total time of soaking was about 7 d, and the deionized water was replaced every 10 h. Following the above procedure, all of the mentioned EuF 3 -NaYF 4 /PNIPAm complex hydrogels were obtained. The structure and fluorescent properties of the complex hydrogels were investigated by differential scanning calorimeter (DSC), photoluminescence (PL), Fourier transform infrared (FTIR), X-ray diffraction (XRD). And the thermosensitive fluorescent behavior of the complex hydrogels was investigated and the mechanism was discussed in detail. The results suggested that, in the PNIPAm hydrogel matrix, energy can be transferred between the bulk doped EuF 3 nanocrystals and NaYF 4 nanocrystals. Either the relative content of two kinds of nanocrystals or the ambient temperature plays an important role in the thermosensitive fluorescent behavior of the complex hydrogels.

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A Crown Ether Appended Super Gelator with Multiple Stimulus Responsiveness

Cited by 258 publications

References 49 publications

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

Multistimuli‐Responsive Supramolecular Gels: Design Rationale, Recent Advances, and Perspectives

Thermosensitive Fluorescent Behavior and Mechanism of EuF₃-NaYF₄Nanocrystals/PNIPAm Ternary Complex Hydrogel

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A Crown Ether Appended Super Gelator with Multiple Stimulus Responsiveness

Cited by 258 publications

References 49 publications

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

Multistimuli‐Responsive Supramolecular Gels: Design Rationale, Recent Advances, and Perspectives

Thermosensitive Fluorescent Behavior and Mechanism of EuF3-NaYF4Nanocrystals/PNIPAm Ternary Complex Hydrogel

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Product

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Thermosensitive Fluorescent Behavior and Mechanism of EuF₃-NaYF₄Nanocrystals/PNIPAm Ternary Complex Hydrogel