A crystalline bisindolylmaleimide with strong solid-state fluorescence of red color and its analogous cross-linked polymer without fluorescence

Abstract

A crystalline bisindolylmaleimide (BIM) 3 with strong fluorescence in the solid state was prepared and studied. Its analogous cross-linked polymer 4 with the same BIMs fluorophore was designed and characterized. The investigation of the covalent bonding networking effect on the solid-state fluorescence was carried out by the comparison between 3 and 4.

Updates on the surface antigens of basophils: CD16 on basophils of patients with respiratory or insect venom allergy and the rejection of CD203c and CD63 externalization decoupling by bisindolylmaleimides

“…Nucleotides that differ between the FCGR3A (mRNA for CD16a) and FCGR3B (mRNA for CD16b) isoforms are indicated at the top of the figure compounds actually serve as red fluorescent materials due to their non-planar structure and D-A system. 19 Various bisindolylmaleimides have fluorescence emission maxima wavelengths longer than 500 nm, with large Stokes shifts longer than 200 nm, and different fluorescence emission wavelengths at an excitation wavelength of 365 nm.…”

“…The two tested PKC inhibitors, Ro‐81‐3220 (bisindolylmaleimide IX) (Figure A) and bisindolylmaleimide II (Figure B) are structurally related to the bis‐indole alkaloid staurosporine. Bisindolylmaleimides in general possess multiple aromatic rings and many of these compounds actually serve as red fluorescent materials due to their non‐planar structure and D‐A system . Various bisindolylmaleimides have fluorescence emission maxima wavelengths longer than 500 nm, with large Stokes shifts longer than 200 nm, and different fluorescence emission wavelengths at an excitation wavelength of 365 nm.…”