A cupric pregnancy – thirteenth time lucky

Young, Terence; Downey, Gabrielle; Maheshwari, M. C.; Nicholl, David

doi:10.1258/shorts.2010.010069

Cited by 5 publications

(6 citation statements)

References 4 publications

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“…Their elevation in pregnant women with history of recurrent spontaneous abortion compared with the control group suggests an increased production of reactive oxygen species. The role of cadmium in recurrent spontaneous abortion is still being studied although it is toxic at low levels for a long term exposure 33 . The finding of higher lead concentration in pregnant women with history of recurrent spontaneous abortion compared with pregnant women without history of recurrent spontaneous abortion is consistent with the findings of HertzPicciotto 10 .…”

Section: Discussionmentioning

confidence: 99%

Progesterone, selected heavy metals and micronutrients in pregnant Nigerian women with a history of recurrent spontaneous abortion

Ajayi¹,

Charles-Davies²,

Arinola³

2012

Af Hlth Sci

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Background: Environmental and endocrine factors have been implicated in the aetiology of recurrent abortion, with poorly understood roles. Luteal phase insufficiency marked with insufficient progesterone secretion has been reported. Objective: To define the involvement of progesterone, trace metals, and Vitamin E in pregnant women with history of recurrent spontaneous abortion. Methods: Convenience sampling method was used to recruit 69 pregnant women aged 21-41 years with gestational age of 0-20 weeks in this case-control study. Thirty five (cases) and thirty four (controls) had previous and no history of recurrent spontaneous abortion respectively. Demographic characteristics and 10mls of blood samples were obtained from each subject. Serum obtained was used for the determination of progesterone, zinc, copper, selenium, iron, magnesium, manganese, chromium, lead, cadmium, and serum vitamin E by standard methods. Results: Results showed statistically significant decreases (p<0.05) in the serum zinc, copper, and vitamin E and a significant elevation (p<0.05) in the serum selenium, lead, and cadmium in cases compared with controls. Insignificant decrease (p=0.07) was observed in the serum progesterone when cases were compared with controls. Conclusion: Results suggest that elevated serum heavy metals (cadmium and lead) and reduction of essential micronutrients (zinc, copper and vitamin E) may contribute to recurrent spontaneous abortion.

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Section: Discussionmentioning

confidence: 99%

Progesterone, selected heavy metals and micronutrients in pregnant Nigerian women with a history of recurrent spontaneous abortion

Ajayi¹,

Charles-Davies²,

Arinola³

2012

Af Hlth Sci

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“…Recent studies have shown that during pregnancy, ATP7B plays a role in transporting copper from the placenta to maternal circulation, thus preventing fetal overload. If dysfunctional, excess copper remains in the fetus and placenta leading to oxidative damage resulting in fetal loss or damage [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Workup for other causes of abnormal elevated copper metabolism were negative in this patient; nevertheless, her treatment and management were the same. Excess copper levels can be associated with preeclampsia secondary to excess buildup in the liver, and the fetus can become growth restricted and have neurological sequelae because of oxidative damage caused by copper accumulation in the placenta and fetal tissue [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Isolated Elevated Copper Levels during Pregnancy

Walker

Rattigan

Canterino

2011

Journal of Pregnancy

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Introduction. Outside of Wilson's Disease, abnormal copper metabolism is a rare condition. In pregnancy, excess copper levels can be associated with intrauterine growth restriction, preeclampsia and neurological disease. Case Report. A 32 year old Gravida 4 para 2012 with an obstetrical history complicated by elevated copper levels presented for routine prenatal care. Her children had elevated copper levels at birth, with her firstborn child being diagnosed with autism and suffering three myocardial infarctions and being treated for elevated copper levels. During her prior pregnancies, she declined treatment for her elevated copper levels. During this pregnancy, she had declined chelation therapy and instead choose zinc therapy. She delivered a healthy infant with normal copper levels. Conclusion. Alterations in copper metabolism are rare, the consequences in pregnancy can be devastating. While isolated elevations of copper in pregnancy is exceedingly rare, it is treated the same as Wilson's disease. The goal is to prevent fetal growth restricting and neurological sequelae in the newborn and preeclampsia in the mother. Counseling, along with treatment options and timely delivery can greatly improve neonatal and maternal outcome.

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“…Again, less diffusion of maternal serum Cu through the placenta may also cause hypercupremia in pregnant women 3 . However, excess copper level in pregnancy can be associated with intrauterine growth retardation in fetus and preeclampsia along with some neurological diseases in mother 14 . Moreover, persistently high copper levels may contribute to postpartum depression due to the effects of metals on nervous tissue.…”

mentioning

confidence: 99%

Serum Copper and Plasma Protein Status in Normal Pregnancy

Noor¹,

Jahan

Sultana³

2013

J Bangladesh Soc Physiol

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Background: Gradual alteration of serum copper and some plasma protein levels may occur with advancement of pregnancy, which is associated with increased maternal and infant morbidity and mortality. Objective: To observe serum copper and plasma protein levels in normal pregnant women of different trimesters in order to find out their nutritional status. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka, between 1 st January 2010 and December 2010. Ninety normal pregnant women of different trimesters with age 20-30 years were included in the study group. They were selected from Out Patient Department of Obstetrics and Gynaecology, SSMC. Age matched 30 non-pregnant women were taken as control. Serum copper level was measured by Spectrophotometric method, serum total protein and albumin levels were estimated by standard method. Statistical analysis was done by one way ANOVA, Bonferroni and Pearson's correlation coefficient test as applicable. Results: Serum Cu levels were significantly higher in all trimesters of pregnant women compared to control. Again, this value was significantly higher in 3 rd trimester than that of in 1 st and 2 nd trimester and also in 2 nd trimester than that of in 1 st trimester. In addition, mean serum total protein level was significantly lower in 3 rd trimester than control but no statistically significant difference was observed among different trimesters. Again, mean serum albumin level was significantly lower in 2 nd and 3 rd trimester than 1 st trimester and control. In addition, serum Cu concentration showed significant positive correlation with different trimesters of gestation. Conclusion: This study reveals that hypercupremia along with hypoproteinemia occur in pregnant women from 1 st to 3 rd trimester of gestation. This gradual alteration of micro and macronutrients become more profound with advancement of pregnancy.

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A cupric pregnancy – thirteenth time lucky

Cited by 5 publications

References 4 publications

Progesterone, selected heavy metals and micronutrients in pregnant Nigerian women with a history of recurrent spontaneous abortion

Progesterone, selected heavy metals and micronutrients in pregnant Nigerian women with a history of recurrent spontaneous abortion

A Case of Isolated Elevated Copper Levels during Pregnancy

Serum Copper and Plasma Protein Status in Normal Pregnancy

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