A Curiously Rare Case of Septic Shock From Clostridium difficile Colitis

Loftus, Kirsten V.; Wilson, Patricia S.

doi:10.1097/pec.0000000000000496

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…13 SS due to CDI could not be identified; however, CDI by itself causing SS is rare, as described in recent literature. 29,30 An important potential bias that needs to be acknowledged is the immortal time bias. The occurrence of CDI in itself can be influenced by pre-CDI hospital LOS.…”

Section: Discussionmentioning

confidence: 99%

National Trends (2007‐2013) of Clostridium difficile Infection in Patients with Septic Shock: Impact on Outcome

Chatterjee

Goyal

Chada

et al. 2017

Journal of Hospital Medicine

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Section: Discussionmentioning

confidence: 99%

National Trends (2007‐2013) of Clostridium difficile Infection in Patients with Septic Shock: Impact on Outcome

Chatterjee

Goyal

Chada

et al. 2017

Journal of Hospital Medicine

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Clostridioides difficile Infection in Children: Recent Updates on Epidemiology, Diagnosis, Therapy

Shirley,

Tornel,

Warren

et al. 2023

Pediatrics

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Clostridioides (formerly Clostridium) difficile is the most important infectious cause of antibiotic-associated diarrhea worldwide and a leading cause of healthcare-associated infection in the United States. The incidence of C. difficile infection (CDI) in children has increased, with 20 000 cases now reported annually, also posing indirect educational and economic consequences. In contrast to infection in adults, CDI in children is more commonly community-associated, accounting for three-quarters of all cases. A wide spectrum of disease severity ranging from asymptomatic carriage to severe diarrhea can occur, varying by age. Fulminant disease, although rare in children, is associated with high morbidity and even fatality. Diagnosis of CDI can be challenging as currently available tests detect either the presence of organism or disease-causing toxin but cannot distinguish colonization from infection. Since colonization can be high in specific pediatric groups, such as infants and young children, biomarkers to aid in accurate diagnosis are urgently needed. Similar to disease in adults, recurrence of CDI in children is common, affecting 20% to 30% of incident cases. Metronidazole has long been considered the mainstay therapy for CDI in children. However, new evidence supports the safety and efficacy of oral vancomycin and fidaxomicin as additional treatment options, whereas fecal microbiota transplantation is gaining popularity for recurrent infection. Recent advancements in our understanding of emerging epidemiologic trends and management of CDI unique to children are highlighted in this review. Despite encouraging therapeutic advancements, there remains a pressing need to optimize CDI therapy in children, particularly as it pertains to severe and recurrent disease.

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A Curiously Rare Case of Septic Shock From Clostridium difficile Colitis

Cited by 2 publications

References 17 publications

National Trends (2007‐2013) of Clostridium difficile Infection in Patients with Septic Shock: Impact on Outcome

National Trends (2007‐2013) of Clostridium difficile Infection in Patients with Septic Shock: Impact on Outcome

Clostridioides difficile Infection in Children: Recent Updates on Epidemiology, Diagnosis, Therapy

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