A current review of molecular mechanisms regarding osteoarthritis and pain

Lee, Andrew S.; Ellman, Michael B.; Yan, Dongyao; Kroin, Jeffrey S.; Cole, Brian J.; Wijnen, André J. van; Im, Hee Jeong

doi:10.1016/j.gene.2013.05.069

Cited by 351 publications

(317 citation statements)

References 78 publications

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“…In the chronic inflammatory process, such as the OA, cells were under pressure and produced cytokines such as IL-1, IL-6, tumor necrosis factor-α (TNF-α) which can cause damage to cells and phospholipids membrane release [14]. In structural components, IL-1 plays an important role in cartilage degradation [16].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Pain Score in Osteoarthritis Patients Treated With a Combination of Diacerein and Meloxicam and Meloxicam Alone

Dwicandra¹,

Setiadi

2017

Int J Pharm Pharm Sci

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Objective: Osteoarthritis (OA) is a progressive chronic disease with the loss of articular cartilage. In managing OA, inadequate pain relief (IPR) often occurs, particularly with a single non steroidal anti-inflammatory drugs (NSAIDs) therapy. In this research, pain outcome of OA patients treated with a combination of diacerein and meloxicam vs meloxicam alone was evaluated.Methods: This research was conducted at rumah sakit umum daerah (RSUD) Dr. Mohammad Soewandhie Surabaya by using randomized controlled trial (RCT) design. Pain outcome was evaluated by pain intensity and area under the curve (AUC) of pain score in week 0-4 th .Results: There were a significantly different (p<0.05) in pain intensity seen in 3 rd and 4 th weeks after treated with a combination of diacerein and meloxicam, and with meloxicam only. However, there were no different in AUC pain score between combination and single therapy. Conclusion:Combination therapy of diacerein and meloxicam was more effective than meloxicam alone. A significant effect of a combination therapy of diacerein and meloxicam occurred at 3 rd weeks. The prolong study in order to get the differences in AUC pain score are needed.

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Section: Discussionmentioning

confidence: 99%

“…It plays an important role in cartilage degradation and stimulation of nociceptive pathways. This mediator shows potent bioactivity in inhibiting synthesis of extracellular matrix (ECM), promoting cartilage damage, and suppressing the expression of an important component of ECM in chondrocytes [16].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Pain Score in Osteoarthritis Patients Treated With a Combination of Diacerein and Meloxicam and Meloxicam Alone

Dwicandra¹,

Setiadi

2017

Int J Pharm Pharm Sci

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“…2) In arthritic cartilage, the progressive destruction of extracellular matrix is mediated by various cartilage-degrading enzymes such as MMPs and aggrecanases.…”

Section: Discussionmentioning

confidence: 99%

“…2) Although various studies on the pathophysiological etiologies of OA are ongoing, many of the factors causing this disease are still unknown. Hence, clinical treatments of OA have been mainly focused on relieving chronic joint pain by suppressing inflammation in the degenerative joint more so than on cartilage regeneration.…”

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confidence: 99%

Biological Effects of the Herbal Plant-Derived Phytoestrogen Bavachin in Primary Rat Chondrocytes

Lee

Cho

Kang

et al. 2015

Biological & Pharmaceutical Bulletin

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The aim of this study was to examine the anabolic and anticatabolic functions of bavachin in primary rat chondrocytes. With bavachin treatment, chondrocytes survived for 21 d without cell proliferation, and the proteoglycan content and extracellular matrix increased. Short-term monolayer culture of chondrocytes showed that gene induction of both aggrecan and collagen type II, major extracellular matrix components, was significantly upregulated by bavachin. The expression and activities of cartilage-degrading enzymes such as matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs were inhibited significantly by bavachin, while tissue inhibitors of metalloprotease were significantly upregulated. Bavachin inhibits the expression of inducible nitric oxide synthase, a representative catabolic factor, and downregulated the expression of nitric oxide, cyclooxygenase-2, and prostaglandin E 2 in a dose-dependent manner in chondrocytes. Our results suggest that the bavachin has anabolic and potent anticatabolic biological effects on chondrocytes, which may have considerable promise in treating articular cartilage degeneration in the future.Key words Osteoarthritis (OA); articular cartilage; chondrocyte; phytoestrogen; bavachin Osteoarthritis (OA) is a representative degenerative disease associated with aging and is the most common type of arthritis.1) The clinical symptoms of OA are defined as chronic joint pain, stiffness, and loss of mechanical joint function caused by progressive cartilage degeneration.2) Moreover, the prevalence of OA is largely age-dependent and is increased significantly in people over age 65.1) Although the prevalence of OA is less in those under 40, prevalence is increasing in these populations because of obesity, individual heredity, mechanical injuries, and surgical trauma of joints.1) The socioeconomic burden associated with OA is increased by both direct medical expenses and indirect costs caused by decreased productivity in the workplace.2) Although various studies on the pathophysiological etiologies of OA are ongoing, many of the factors causing this disease are still unknown. Hence, clinical treatments of OA have been mainly focused on relieving chronic joint pain by suppressing inflammation in the degenerative joint more so than on cartilage regeneration.Homeostasis of articular cartilage is precisely regulated by the balance between synthesis (anabolism) and degradation (catabolism) of the extracellular matrix (ECM), which is mainly composed of collagen Type II and proteoglycan synthesized from chondrocytes to maintain mechanical function in response to a compressive overload on joints.3) However, perturbations in chondrocytes with normal metabolic properties induce the progressive destruction of ECM through the up-regulation of cartilage-degrading enzymes such as matrix metalloproteinase (MMP)-13, MMP-3, MMP-1, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4 and ADAMTS-5.3) Recent research has focused on cartilage regenerati...

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“…Sutovsky J., 1 Kocmalova M., 2,3 Benco M., 1 Kazimierova I., Pappova L., 2,3 Frano A., 4 Sutovska M., 2,3 Background: Degenerative spine disorders (DSD) are the most frequent reason of morbidity in adults. Commonly DSD includes degenerative disorders of intervertebral discs (IVDs), spinal stenosis and degenerative spondylolisthesis (SL).…”

Section: The Role Of Cytokines In Degenerative Spine Disordersmentioning

confidence: 99%

The role of cytokines in degenerative spine disorders

Šutovský

Kočmálová

Benčo

et al. 2017

European Pharmaceutical Journal

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The degenerative spine disorders (DSD) includes disorders of intervertebral discs (IVDs) and degenerative spondylolisthesis. DSD represents the most frequent reason of morbidity in adults and its incidence rises with age. The common clinical signs of DSD are pain and mobility impairment, as the consequence of spinal roots and spinal cord compression by herniated IVDs, spinal canal stenosis, osteoarthrosis and damage of facet joints (FJs) cartilage. The pain can appear without evident neuronal compression due to the local release of cytokines and chemokines. It has been recently appointed a significant role of cytokines, not only in pain mediation, but also in DSD progression (Wuertz and Haglund, 2013). IVDs consist of annulus fibrosus (AF) and nucleus pulposus (NP). While collagen represents the main compound of AF, NP comprises proteoglycans and water. One of the early symptoms of IVD degeneration is reduced hydration of NP, followed by subsequent biochemical and structural changes that change the mechanic loading of spine (Risbud and Shapiro, 2014). The role of cytokines in degenerative spine disordersSutovsky J., 1 Kocmalova M., 2,3 Benco M., 1 Kazimierova I., Pappova L., 2,3 Frano A., 4 Sutovska M., 2,3 Background: Degenerative spine disorders (DSD) are the most frequent reason of morbidity in adults. Commonly DSD includes degenerative disorders of intervertebral discs (IVDs), spinal stenosis and degenerative spondylolisthesis (SL). There is increasing evidence about significant role of cytokines in DSD pathogenesis, symptomathology and progression, but their protective levels remain still unknown. Material and Methods: The aim of presented study was to provide quantitative and qualitative analysis of cytokine, chemokine and growth factors levels in individual parts of IVDs -annulus fibrosus (AF) and nucleus pulposus (NP) -separately and in facet joints (FJ) subchondral bone of patients with DSD and in controls -healthy subjects during a multiorgan procurement procedure. Bio-Plex® assay was used to measure concentrations of 27 different cytokines in tissue of patients with DSD. Their concentrations in tissues of healthy subjects during a multiorgan procurement procedure represented protective levels. Results: The Bio-Plex® assay revealed significant differences between the patients suffered from degenerated and herniated IVDs and from lumbar SL and controls in cytokines, chemokines and growth factor profiles suggested that pro-inflammatory changes of both NP and AF were dominated in herniated IVDs, whereas the same tissue of lumbar SL patients exhibited much more complex changes in cytokine levels suggested o only ongoing inflammation (IL-6, IL-8, MCP-1, TNF-α), abut also antiinflammatory processes (IL-ra, IL-10) or connective tissue remodeling (PDGF-bb, IL-17, VEGF). The different mediators were found elevated in lumbar SL samples of subchondral FJ bone. These also confirmed ongoing inflammation, accelerated bone resorption and formation and increased fibroblasts activity in FJ bone. Conclusion: The study s...

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A current review of molecular mechanisms regarding osteoarthritis and pain

Cited by 351 publications

References 78 publications

Comparison of Pain Score in Osteoarthritis Patients Treated With a Combination of Diacerein and Meloxicam and Meloxicam Alone

Comparison of Pain Score in Osteoarthritis Patients Treated With a Combination of Diacerein and Meloxicam and Meloxicam Alone

Biological Effects of the Herbal Plant-Derived Phytoestrogen Bavachin in Primary Rat Chondrocytes

The role of cytokines in degenerative spine disorders

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