A Current-Sensitive Front-End Amplifier for Nano-Biosensors with a 2MHz BW

Ferrari, Giorgio; Gozzini, Fabio; Sampietro, Marco

doi:10.1109/isscc.2007.373345

Cited by 37 publications

(19 citation statements)

References 4 publications

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“…The third type of amperometric readout circuit that has been widely reported [ 47 , 57 , 66 , 69 , 83 , 84 , 85 , 86 ] is the current conveyor structure, which uses a front-end current mode amplifier to eliminate noise from the following stages. Figure 11 depicts a typical current conveyor schematic for which the measured biosensor current I sn can be calculated by:

where I* sn is the current conveyor output current and W/L is size of current mirror transistors M 1 and M 2 .…”

Section: Cmos Instrumentation For Amperometric and Impedimetric Bimentioning

confidence: 99%

CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

Liu²,

et al. 2016

Sensors

150

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Modern biosensors play a critical role in healthcare and have a quickly growing commercial market. Compared to traditional optical-based sensing, electrochemical biosensors are attractive due to superior performance in response time, cost, complexity and potential for miniaturization. To address the shortcomings of traditional benchtop electrochemical instruments, in recent years, many complementary metal oxide semiconductor (CMOS) instrumentation circuits have been reported for electrochemical biosensors. This paper provides a review and analysis of CMOS electrochemical instrumentation circuits. First, important concepts in electrochemical sensing are presented from an instrumentation point of view. Then, electrochemical instrumentation circuits are organized into functional classes, and reported CMOS circuits are reviewed and analyzed to illuminate design options and performance tradeoffs. Finally, recent trends and challenges toward on-CMOS sensor integration that could enable highly miniaturized electrochemical biosensor microsystems are discussed. The information in the paper can guide next generation electrochemical sensor design.

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where I* sn is the current conveyor output current and W/L is size of current mirror transistors M 1 and M 2 .…”

Section: Cmos Instrumentation For Amperometric and Impedimetric Bimentioning

confidence: 99%

CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

Liu²,

et al. 2016

Sensors

150

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“…5 shows the schematic of the proposed bandpass TIA. Similar topology has been used in a front-end amplifier for nano-biosensors [37], but with more sophisticated DC feedback circuit and high power consumption. This work demonstrates its suitability for MEMS oscillator related applications, especially for MEMS oscillating accelerometer.…”

Section: A Review Of Existing Tias For Mems Applicationsmentioning

confidence: 99%

A Sub-µg Bias-Instability MEMS Oscillating Accelerometer With an Ultra-Low-Noise Read-Out Circuit in CMOS

Zhao

Wang

et al. 2015

IEEE J. Solid-State Circuits

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This paper describes a SOI MEMS oscillating accelerometer with a fully differential CMOS continuous-time read-out circuit. A new ultra-low-noise continuous-time bandpass transimpedance amplifier (TIA) is proposed and serves as the front-end of the read-out circuit. The new TIA topology greatly relaxes the tradeoffs among gain, bandwidth and noise, and achieves a state-of-the-art input referred current noise density of 6.6 fA/ Hz, which helps improve the bias-instability and noise floor of the MEMS oscillating accelerometer. The TIA provides a transimpedance gain of 45 MΩ in the bandwidth from 0.5 Hz to 350 kHz and consumes only 583 µW. To reduce the amplitude-stiffness effect induced frequency variation, the accelerometer employs a displacement control strategy that stabilizes the oscillation amplitude of the MEMS oscillator and a chopper stabilization technique to minimize the flicker noise in the amplitude control block. The accelerometer yields bias-instability of 0.6 µg (Allan Variance) or bias stability of 6.3 µg (1σ in one hour) and 2 µg/ Hz noise floor with 140 Hz/g scale factor and ±20 g full scale. The overall power consumption of the accelerometer is 3.5 mW under a 1.5 V supply.

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“…An LC oscillator is a basic component for local oscillation (LO) generation in radio-frequency (RF) integrated circuits [23]. An inductor and a fixed capacitor oscillate at a free running frequency f 0 , driven by a negative resistance from a cross-coupled transistor pair.…”

Section: Overviewmentioning

confidence: 99%

Silicon-based Integrated Microarray Biochips for Biosensing and Biodetection Applications

Zhang¹,

Zhu²,

Geng³

et al. 2015

Biosensors - Micro and Nanoscale Applications

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The silicon-based integrated microarray biochip (IMB) is an inter-disciplinary research direction of microelectronics and biological science. It has caught the attention of both industry and academia, in applications such as deoxyribonucleic acid (DNA) and immunological detection, medical inspection and point-of-care (PoC) diagnosis, as well as food safety and environmental surveillance. Future biodetection strategies demand biochips with high sensitivity, miniaturization, integration, parallel, multi-target and even intelligence capabilities. In this chapter, a comprehensive investigation of current research on state-of-the-art siliconbased integrated microarray biochips is presented. These include the electrochemical biochip, magnetic tunnelling junction (MTJ) based biochip, giant magnetoresistance (GMR) biochip and integrated oscillator-based biochip. The principles, methodologies and challenges of the aforementioned biochips will also be discussed and compared from all aspects, e.g., sensitivity, fabrication complexity and cost, compatibility with silicon-based complementary metal-oxidesemiconductor (CMOS) technology, multi-target detection capabilities, signal processing and system integrations, etc. In this way, we discuss future siliconbased fully integrated biochips, which could be used for portable medical detection and low cost PoC diagnosis applications.

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A Current-Sensitive Front-End Amplifier for Nano-Biosensors with a 2MHz BW

Cited by 37 publications

References 4 publications

CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

A Sub-µg Bias-Instability MEMS Oscillating Accelerometer With an Ultra-Low-Noise Read-Out Circuit in CMOS

Silicon-based Integrated Microarray Biochips for Biosensing and Biodetection Applications

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