A current understanding of multiple sclerosis

Shull, Catherine; Hoyle, B.; Iannotta, Caylin; Fletcher, E. Gordon; Curan, Megan; Cipollone, Victoria

doi:10.1097/01.jaa.0000651716.72042.21

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…Data on MS from South India are inadequate. The femaleto-male ratio of 4:1 suggested a higher female predominance, which is similar to the results of previous studies from India and other countries [4,[11][12][13][14][15]. Fourteen (70%) patients were adults, and the remaining six patients (30%) were adolescents at illness onset.…”

Section: Discussionsupporting

confidence: 88%

The Clinical Spectrum of Multiple Sclerosis in a Tertiary Care Hospital

Madineni,

S V,

Bhuma

2023

J Neurol Res

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Background: Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, demyelinating disease of the central nervous system (CNS) mediated by an inappropriate immune response within the body against the insulating myelin sheath. Methods:Between January 2016 and March 2019, 20 diagnosed cases of MS were recruited for the study. Patient history was collected using a pre-designed standardized clinical proforma. Results:The outcomes of the present study reveal a resemblance of MS patterns in Andhra Pradesh with India and with the West. MS is more common in women. The second and third decades are the most common. The incidence of the disease decreased with age. In comparison to relapsing-remitting MS (RRMS), primary-progressive MS (PPMS) had a younger onset age. The most common type of MS is RRMS. Individuals had different relapse rates. Relapses are more common in patients who first develop the disease at a young age. In PPMS patients, oligoclonal band (OCB) positivity is higher than in RRMS patients. A considerable number of individuals exhibited aberrant visual evoked potential (VEP) even in the absence of visual complaints. Disease-modifying drugs decreased the disease frequency and severity. Patients who started these drugs after 1 -2 relapses had good results. Conclusion:According to the findings, larger data sets are needed to completely characterize disease patterns. Given the rising prevalence of MS across India, it has become necessary to establish regional and national MS registries.

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Section: Discussionsupporting

confidence: 88%

The Clinical Spectrum of Multiple Sclerosis in a Tertiary Care Hospital

Madineni,

S V,

Bhuma

2023

J Neurol Res

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“…A small proportion of the study cohort were men (13.5%). Although this is a common issue among MS-related cohorts, given that MS affects nearly three times as many women compared to men ( Shull et al, 2020 ), it suggests that the results of the DIF analysis assessing the influence of sex should be interpreted with caution. The high education level of our cohort may have resulted in the observed gaps in the domain targeting.…”

Section: Strengths Limitations and Future Researchmentioning

confidence: 99%

Measurement Properties of the Health Literacy Questionnaire in the Understanding Multiple Sclerosis Massive Open Online Course Cohort: A Rasch Analysis

Bessing¹,

Honan²,

Mei³

et al. 2022

HLRP: Health Literacy Research and Practice

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Background: Online health education and other electronic health improvement strategies are developing rapidly, highlighting the growing need for valid scales to assess health literacy (HL). One comprehensive HL scale is the Health Literacy Questionnaire (HLQ), but little is known about its measurement properties in online health education cohorts. Objective: The purpose of this study was to determine if the multidimensional HLQ is an appropriate tool to measure HL in a cohort of Understanding Multiple Sclerosis (MS) online course enrollees. Methods: Participants who enrolled in the first two open enrollments of the Understanding MS online course completed the HLQ ( N = 1,182) in an online survey prior to beginning course materials. We used Rasch analysis to assess the measurement properties of the HLQ. Key Results: The nine Domains of the HLQ each had ordered category function and a good fit with the Rasch model. Each domain was one-dimensional and exhibited good internal consistency and reliability. None of the 44 individual items of the HLQ demonstrated item bias or local dependency. However, while the overall fit was good, few measurement gaps were identified in this cohort for participants in each of the nine Domains, meaning that the HLQ may have low measurement precision in some participants. Conclusion: Our analysis of the HLQ indicated acceptable measurement properties in a cohort of Understanding MS online course enrollees. Although reliable information on nine separate constructs of HL was obtainable in the current study indicating that the HLQ can be used in similar cohorts, its limitations must be also considered. [ HLRP: Health Literacy Research and Practice . 2022;6(3):e200–e212. ] Plain Language Summary: In this study, we have shown that the HLQ is suitable for measuring HL in an online public health educational platforms for chronic diseases including multiple sclerosis. This finding adds to the evidence that the HLQ can be widely used in measuring HL in different settings, populations, and health educational platforms.

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“…Worldwide, more than 2.8 million people suffer from MS, representing the most common non-traumatic neuroimmunological disease in young adults [ 2 , 3 ]. MS symptoms can vary from acute unilateral optic neuritis, diplopia, nystagmus, trigeminal neuralgia, sensory loss, motor disturbances, cerebellar ataxia, urinary urge incontinence and constipation to erectile dysfunction [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Depression and Anxiety in Association with Polypharmacy in Patients with Multiple Sclerosis

Baldt,

Frahm,

Hecker

et al. 2023

JCM

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Polypharmacy (intake of ≥5 drugs) is an important issue for patients with chronic diseases such as multiple sclerosis (MS). We aimed to assess the prevalence of polypharmacy with regard to the severity of anxiety/depression and to comorbidities. Therefore, 374 MS patients from two German neurological sites were examined for drug burden, comorbidities, disability level and psychopathological measures capturing depression and anxiety using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D). We found that patients with a higher HADS-D score take more medication (r = 0.217, p < 0.001). Furthermore, patients with higher depression severity were more likely to show polypharmacy (p < 0.001). These differences were not significant for anxiety. (p = 0.413). Regarding the frequency of ≥1 comorbidities, there were no significant differences between patients with different HADS-A (p = 0.375) or HADS-D (p = 0.860) severity levels, whereas the concrete number of comorbidities showed a significant positive linear correlation with HADS-A (r = 0.10, p = 0.045) and HADS-D scores (r = 0.19, p < 0.001). In conclusion, symptoms of depression pose a relevant issue for MS patients and are correlated with polypharmacy and comorbidities. Anxiety is not correlated with polypharmacy but with the frequency of several comorbidity groups in MS patients.

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A current understanding of multiple sclerosis

Cited by 6 publications

References 20 publications

The Clinical Spectrum of Multiple Sclerosis in a Tertiary Care Hospital

The Clinical Spectrum of Multiple Sclerosis in a Tertiary Care Hospital

Measurement Properties of the Health Literacy Questionnaire in the Understanding Multiple Sclerosis Massive Open Online Course Cohort: A Rasch Analysis

Depression and Anxiety in Association with Polypharmacy in Patients with Multiple Sclerosis

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