A curvature-based approach to estimate local gyrification on the cortical surface

Lüders, Eileen; Thompson, Paul M.; Narr, Katherine L.; Toga, Arthur W.; Jäncke, Lutz; Gaser, Christian

doi:10.1016/j.neuroimage.2005.08.049

Cited by 325 publications

(281 citation statements)

References 36 publications

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“…We used a general linear model controlling for the effect of age and total cortical surface area to estimate differences in gyrification between the groups at each vertex of the right and left hemispheric surfaces. Total surface area was chosen as a covariate as it has a linear relationship with gyrification, 32 and we have previously noted a significant difference between patients and controls in total surface area. 24 This model allowed for the possibility that the slope for the relationship between LGI and total surface area may be different in different brain regions.…”

Section: Discussionmentioning

confidence: 99%

Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study

Palaniyappan

Liddle

2012

J Psychiatry Neurosci

116

103

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IntroductionSchizophrenia is regarded as a disorder of connectivity associated with neurodevelopmental abnormality.1 Despite accumulating evidence for disturbances in functional connectivity, 2 it is unclear how these findings are related to defective cortical development.Developmental aberrations can affect several characteristic anatomic features of the grey matter surface. Cortical development is constrained by the need to develop a cost-efficient wiring scheme wherein signal transmission is quick and effective 3 and by the limitations on the total brain size partly to facilitate parturition. 4,5 This is facilitated by a substantial expansion of surface area along with a high degree of cortical folding despite a relatively minor gain in cortical thickness during evolutionary development. 6 This remarkable dissociation between thickness and surface area persists in adult human brains. 7Axonal connections in the developing brain are considered to be one of several factors that influence the morphology of the cortical surface. 8 In particular, a widely accepted model of cortical morphogenesis suggests that the appearance of cortical convolutions is dependent on the underlying neuronal connectivity.9 Disturbances in regional cortical gyrification can be a surrogate marker for disruptions in neuronal connectivity during development. 9,10Most studies examining neuroanatomical changes in patients with schizophrenia have employed voxel-based morphometry (VBM) and report consistent volume reduction bilaterally in the insula and anterior cingulate cortex (ACC). Compared with the number of studies investigating volumetric defects, relatively few studies have attempted to locate gyrification defects within the entire cortex in patients with schizophrenia (see White and Hilgetag 10 for a detailed review). Most previous investigations have quantified differences in gyrification at preselected regions of interest (ROI), Background: Schizophrenia is considered to be a disorder of cerebral connectivity associated with disturbances of cortical development. Disturbances in connectivity at an early period of cortical maturation can result in widespread defects in gyrification. Investigating the anatomic distribution of gyrification defects can provide important information about neurodevelopment in patients with schizophrenia. Methods: We undertook an automated surface-based morphometric assessment of gyrification on 3-dimensionally reconstructed cortical surfaces across multiple vertices that cover the entire cortex. We used a sample from our previous research of 57 patients (50 men) with schizophrenia and 41 controls (39 men) in whom we had tested a specific hypothesis regarding presence of both hypoand hypergyria in the prefrontal cortex using a frontal region-of-interest approach. Results: Regions with significant reductions in gyrification (hypogyria) were seen predominantly in the left hemisphere, involving the insula and several regions of the multimodal association cortex. Although the prefrontal hypergyria documented ea...

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Section: Discussionmentioning

confidence: 99%

Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study

Palaniyappan

Liddle

2012

J Psychiatry Neurosci

116

103

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“…[25][26][27] The middle cortical surface lies at the geometric midpoint between the inner and outer cortical surfaces. It provides a relatively unbiased representation of sulcal versus gyral regions.…”

Section: Cortical Surface Areamentioning

confidence: 99%

Effect of Illiteracy on Cognition and Cerebral Morphology in Later Life

Kwon

Yoon

2015

Dement Neurocognitive Disord

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Background and Purpose A better developmental environment has positive effects on brain development. The acquisition of literacy during childhood may affect brain functional organization. The present study aimed to evaluate the effects of illiteracy on neuropsychological test results and cerebral morphology in later life. Methods We recruited 7 illiterate elderly farmers who had never attended school and had no reading or writing knowledge. These subjects were compared with 9 literate subjects in terms of neuropsychological performance and brain volume. All subjects were over 65-years-old and had the same regional and occupational background. Results Neuropsychological tests indicated that the performance of the illiterate subjects was worse than that of literate subjects in all cognitive domains except forward digit span, tool-use and tool-free gestures, verbal word recognition, and verbal generation of animals and grocery items. The illiterate group also showed significantly decreased cortical volume and surface area in both parietal lobes. However, the illiterate group showed increased cortical thickness in the left cuneus. Conclusions Literacy acquired in childhood may increase the volume of the parietal lobe and improve neuropsychological performance through the process of brain plasticity. The effects can be lifelong.

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“…Others [Magnotta et al, 1999, Cachia et al, 2003, Toro and Burnod, 2003, Manguin et al, 2004, Batchelor et al, 2002, Luders et al, 2006, Dubois et al, 2007 have computed curvature on 3D triangular meshes, created to approximate the brain surface. Computation of curvature [Gatzke andGrimm, 2006, Rusinkiewicz, 2004] from a triangular mesh can be done with the so called direct methods, which imply direct approximation of a curvature (or of a curvature tensor) within a neighborhood of a point (low computational cost), or by surface fitting, which involves finding an analytic equation that fits the mesh locally (high computational costs).…”

Section: Relation To Other Approachesmentioning

confidence: 99%

A framework for in vivo quantification of regional brain folding in premature neonates

et al. 2008

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A curvature-based approach to estimate local gyrification on the cortical surface

Cited by 325 publications

References 36 publications

Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study

Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study

Effect of Illiteracy on Cognition and Cerebral Morphology in Later Life

A framework for in vivo quantification of regional brain folding in premature neonates

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