A cutaneous apudoma or merkel cell tumor? A morphologically recognizable tumor with a biological and histological malignant aspect in contrast with its clinical behavior

Wolf‐Peeters, Chris De; Mariën, K.; Mebis, Joseph; Desmet, Valeer

doi:10.1002/1097-0142(19801015)46:8<1810::aid-cncr2820460819>3.0.co;2-7

Cited by 169 publications

(54 citation statements)

References 6 publications

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“…This tumor was named ''Merkel cell carcinoma'' by De Wolf-Peeters et al in 1980. 5 Merkel cells are believed to be of neuroectodermal origin, 2 and are found in the basal layer of the epidermis as single cells. They also form aggregates in the tactile hair discs of Pinkus where they function as slowly adapting type I mechanoreceptors.…”

mentioning

confidence: 99%

Immunohistochemical Distinction Between Merkel Cell Carcinoma and Small Cell Carcinoma of the Lung

Bobos

Hytiroglou²,

Kostopoulos³

et al. 2006

The American Journal of Dermatopathology

229

152

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We assessed the usefulness of several immunohistochemical stains in distinguishing these two neoplasms, including cytokeratin 7, cytokeratin 20 (CK20), neuron-specific enolase, chromogranin, synaptophysin, neurofilaments (NF), thyroid-transcription factor-1 (TTF-1), CD56 antigen, S-100 protein, vimentin, c-erbB-2 oncoprotein, and CD117 antigen. All 13 cases of Merkel cell carcinoma evaluated were positive for CK20, and negative for TTF-1. Twelve of 13 Merkel cell carcinoma cases were positive for NF. Eleven of 13 cases of small cell lung carcinoma were positive for TTF-1. All small cell lung carcinoma cases were negative for NF, and all but one were negative for CK20. In terms of the remaining antigens, there were no differences of significance between the two neoplasms. These findings suggest that a set of three immunohistochemical stains, including CK20, NF, and TTF-1, is useful in affording a distinction between Merkel cell carcinoma and small cell lung carcinoma.

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mentioning

confidence: 99%

Immunohistochemical Distinction Between Merkel Cell Carcinoma and Small Cell Carcinoma of the Lung

Bobos

Hytiroglou²,

Kostopoulos³

et al. 2006

The American Journal of Dermatopathology

229

152

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“…[2] In 1972, Toker described five cases of what he called [3,4] Mrerkel cell carcinoma is a rare malignancy appearing in the sixth to seventh decade of life, with a slight male preponderance. It affects predominantly the Caucasian race and is exceptionally rare in dark-skinned people.…”

Section: Discussion Discussionmentioning

confidence: 99%

Spontaneous regression in an ulcerated CK7 positive Merkel cell carcinoma

Khader¹,

George²,

Balakrishnan³

et al. 2015

Indian J Dermatol Venereol Leprol

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Merkel cell carcinoma is an aggressive and frequently lethal tumor of the elderly, associated with sun exposure and immunosuppression which is less common in the dark-skinned. We report the case of a 40-year-old woman who presented with multiple slowly progressive, mildly itchy ulcerated plaques of size ranging from 2 × 3 cm to 5 × 7 cm on the left knee of 1 year duration. Skin biopsy showed diffuse dermal infiltration by small round cells with molding of cells and lymphocyte infiltration. The cells stained positive for cytokeratin (CK) 20, CK7, neuron-specific enolase, and chromogranin. The skin lesions underwent spontaneous regression within 1 month of skin biopsy and have not recurred during the past 2 years. The immune mechanisms triggered by biopsy possibly explain the spontaneous regression.

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“…[3] The name Merkel cell carcinoma was suggested by De Wolf-Peeters et al, in 1980. [4] Most cases of MCC are reported in the elderly, with a notable high incidence in subjects with AIDS or with a prior history of organ transplantation. [5] The classical clinical presentation is a rapidly expanding, 1-2 cm sized, asymptomatic, red/pink nodule seen on sun-exposed skin.…”

Section: Discussionmentioning

confidence: 99%