A cutaneous full-thickness liquid sulfur mustard burn model in weanling swine: clinical pathology and urinary excretion of thiodiglycol†‡

Graham, John S.; Reid, Frances M.; Smith, J. Richard; Stotts, Richard R.; Tucker, F. Steven; Shumaker, Shawn M.; Niemuth, Nancy A.; Janny, Stephen J.

doi:10.1002/1099-1263(200012)20:1+<::aid-jat681>3.0.co;2-t

Cited by 24 publications

(12 citation statements)

References 23 publications

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“…It is an alkalizating agent and its exposure to human skin may cause severe injuries. It makes the epidermis separated from the dermis at the dermal epidermal junction [3, 4]. Skin lesions usually occur within hours after exposure; eritema and the swellings occur first and then followed by the ulcer and the necrosis [2].…”

Section: Discussionmentioning

confidence: 99%

Phytocontact Dermatitis due to Mustard Seed Mimicking Burn Injury: Report of a Case

Yabanoğlu

Akbulut²,

Karakayalı³

2012

Case Reports in Medicine

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Mustard seeds have been used in traditional folk medicine as a stimulant, diuretic, and purgative and to treat a variety of ailments including peritonitis and neuralgia. Mustards are still used today in mustard plasters to treat rheumatism, arthritis, chest congestion, aching back, and sore muscles. To make a mustard plaster, mix equal parts of flour and powdered mustard and spread it as a paste on a doubled piece of soft cloth. Apply mustard plaster to the affected area for a maximum of 15 minutes. Prolonged application can result in burns to the skin and nerve damage. Skin lesions occur within hours after exposure, and there is no significant therapy procedure. This case report is about a patient with second-degree burn, occurred when a mixture including mustard seed was exposed to her skin in the pain therapy of the osteoarthritis in her left knee. There are no studies analyzing treatment of skin burns induced by mustard seed in the literature. While in this type of burns our experience is limited, we think that conservative approach should be first choice of treatment.

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Section: Discussionmentioning

confidence: 99%

Phytocontact Dermatitis due to Mustard Seed Mimicking Burn Injury: Report of a Case

Yabanoğlu

Akbulut²,

Karakayalı³

2012

Case Reports in Medicine

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“…In many cases, wild-type pigs are being used as models already. Wild-type pigs are particularly useful for studying cardiovascular disease (2), atherosclerosis (3), cutaneous pharmacology (4), wound repair (5), cancer (6), diabetes (7), and ophthalmology (8). In many cases, they are the species of choice for translational medicine (9, 10).…”

Section: Importance Of Pigs As Biomedical Modelsmentioning

confidence: 99%

Genetically Engineered Pig Models for Human Diseases

Prather¹,

Lorson²,

Ross³

et al. 2013

Annu. Rev. Anim. Biosci.

150

117

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Although pigs are used widely as models of human disease, their utility as models has been enhanced by genetic engineering. Initially, transgenes were added randomly to the genome, but with the application of homologous recombination, zinc finger nucleases, and transcription activator-like effector nuclease (TALEN) technologies, now most any genetic change that can be envisioned can be completed. To date these genetic modifications have resulted in animals that have the potential to provide new insights into human diseases for which a good animal model did not exist previously. These new animal models should provide the preclinical data for treatments that are developed for diseases such as Alzheimer's disease, cystic fibrosis, retinitis pigmentosa, spinal muscular atrophy, diabetes, and organ failure. These new models will help to uncover aspects and treatments of these diseases that were otherwise unattainable. The focus of this review is to describe genetically engineered pigs that have resulted in models of human diseases.

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“…Superficial-dermal skin lesions were induced on the abdominal flank of six pigs by controlled exposure to sulphur mustard using a standard dosing procedure involving the application of undiluted agent for up to 8 min (Graham et al, 2000). Two days post-exposure, the animals were placed under (terminal) anaesthesia and the end of a brass cylinder (300 g; 3 cm diameter; ∼21 • C) was manually placed onto an area of normal or damaged skin for 5 s to induce cooling.…”

Section: School Of Biomedical and Molecular Sciences University Of Smentioning

confidence: 99%

BTS Abstracts October 2005

2006

Toxicology

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A cutaneous full-thickness liquid sulfur mustard burn model in weanling swine: clinical pathology and urinary excretion of thiodiglycol†‡

Cited by 24 publications

References 23 publications

Phytocontact Dermatitis due to Mustard Seed Mimicking Burn Injury: Report of a Case

Phytocontact Dermatitis due to Mustard Seed Mimicking Burn Injury: Report of a Case

Genetically Engineered Pig Models for Human Diseases

BTS Abstracts October 2005

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