A cutaneous presentation of a common condition

Daunton, Adam; Langman, Gerald; Goulding, Jon

doi:10.1136/bmj.h6711

Cited by 6 publications

(24 citation statements)

References 12 publications

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“…MCD has a heterogenous clinical presentation including erythematous and violaceous plaques, nodules, ulcerations, crusts, and erosions. The “knife‐cut” sign describes cutaneous linear erosions seen in MCD . The most common presentation of MCD is genital swelling .…”

Section: Clinical Presentationmentioning

confidence: 99%

“…MCD can precede, occur concurrently with, or follow gastrointestinal symptoms . Several cohorts of cases have shown that MCD appears to occur at the same time as diagnosis of pediatric cutaneous CD in approximately half of cases .…”

Section: Clinical Presentationmentioning

confidence: 99%

“…A 1997 review of 14 cases showed that two‐thirds of the children had genital involvement at presentation and that 11 had cutaneous manifestations before intestinal disease . There is no correlation between severity of gastrointestinal disease and MCD, but cutaneous findings tend to occur more frequently with large bowel disease …”

Section: Clinical Presentationmentioning

confidence: 99%

“…Although not considered MCD because of contiguity with the gastrointestinal tract, 25%‐30% of patients have perianal lesions upon clinical examination before development of gastrointestinal complaints . Perianal fistulae and fissures are strongly suggestive of CD, and approximately half of patients with Crohn's disease will develop perianal fissures in their lifetime . Keiler and colleagues found that 22 of 27 (81.5%) pediatric cases had perianal disease on presentation .…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Our review showed a similar incidence of 71.0% in patients with perianal disease. Other clinical presentations of extraintestinal CD include aphthous ulcers and granulomatous cheilitis (Figure ), which have a lifetime incidence of approximately 10% …”

Section: Clinical Presentationmentioning

confidence: 99%

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Cutaneous manifestations of metastatic Crohn's disease

Schneider

Foster²,

Patel

et al. 2018

Pediatric Dermatology

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Metastatic Crohn's disease is a rare cutaneous complication of primary Crohn's disease. It is a granulomatous inflammatory process, similar to the pathogenic mechanism of Crohn's disease, that occurs in sites discontiguous from the gastrointestinal tract. Metastatic Crohn's disease can precede the development of Crohn's disease by months to years, and children are more likely to present with metastatic Crohn's disease in the absence of gastrointestinal symptoms. Given that approximately 30% of individuals with Crohn's disease present in childhood, early recognition of extraintestinal manifestations of Crohn's disease such as metastatic Crohn's disease can aid in timely diagnosis and management of bowel disease. We present data from two pediatric cases of metastatic Crohn's disease recently seen at our institution in addition to the 61 reported cases of pediatric metastatic Crohn's disease in the literature. This review article will focus on the epidemiology, pathogenesis, clinical features, and histology of and treatment options for pediatric metastatic Crohn's disease.

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Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

See 3 more Smart Citations

Cutaneous manifestations of metastatic Crohn's disease

Schneider

Foster²,

Patel

et al. 2018

Pediatric Dermatology

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Intertriginous Condyloma-like Plaques and Ulcers

2018

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Plaques and skin ulcers in a child with inflammatory bowel disease: A diagnostic challenge

Ashworth

Freitas

Coelho

et al. 2022

J Paediatrics Child Health

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A previously healthy 12-year-old boy, with no relevant family history, presented to the dermatology outpatient clinics with ulcers with well-defined border, nodules and erythematousviolaceous plaques, on his left leg (Fig. 1), with an intermittent evolution over the last 4 years. Two years after the appearance of skin lesions, he also had sporadic abdominal pain, oral aphthae, every 2 months, and elbow and right knee pain, without heat, redness, loss of function or joint swelling. No fever, blood or mucus in stool. Analytic tests revealed an elevated erythrocyte sedimentation rate of 54 mm/h (normal range 0-19 mm/h), a C-reactive protein of 18.05 mg/L (normal range 0-5 mg/L) and elevated faecal calprotectin, 1690 μg/g (normal range < 50 μg/g). Viral serologies and Interferon Gamma Release Assay tests were negative.

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A cutaneous presentation of a common condition

Cited by 6 publications

References 12 publications

Cutaneous manifestations of metastatic Crohn's disease

Cutaneous manifestations of metastatic Crohn's disease

Intertriginous Condyloma-like Plaques and Ulcers

Plaques and skin ulcers in a child with inflammatory bowel disease: A diagnostic challenge

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