The influence of engine speed, torque, oil temperature, and piston liner clearance on the block vibration was studied with experimental test and wavelet packet decomposition method (WPD). The wavelet packet function of db10 and decomposition level of four was confirmed based on the Shannon entropy. The frequency analysis of the block vibration measured at motor-driven condition showed that the spectrum energy was mainly concentrated in the range of 4–5, 10–15, and 20–25 kHz. The energy of each frequency band obtained from WPD was contrasted at different engine speed, torque, oil temperature, and piston-liner clearance conditions. On this basis, the interaction between different factors was further investigated. The sensitive frequency band of block vibration was confirmed for different factors.