Dengue is a distinctive and fatal infectious disease that spreads through female mosquitoes called Aedes aegypti. It is a notable concern for developing countries due to its low diagnosis rate. Dengue has the most astounding mortality level as compared to other diseases due to tremendous platelet depletion. Hence, it can be categorized as a life-threatening fever as compared to the same class of fevers. Additionally, it has been shown that dengue fever shares many of the same symptoms as other flu-based fevers. On the other hand, the research community is closely monitoring the popular research fields related to IoT, fog, and cloud computing for the diagnosis and prediction of diseases. IoT, fog, and cloud-based technologies are used for constructing a number of health care systems. Accordingly, in this study, a DengueFog monitoring system was created based on fog computing for prediction and detection of dengue sickness. Additionally, the proposed DengueFog system includes a weighted random forest (WRF) classifier to monitor and predict the dengue infection. The proposed system’s efficacy was evaluated using data on dengue infection. This dataset was gathered between 2016 and 2018 from several hospitals in the Delhi-NCR region. The accuracy, F-value, recall, precision, error rate, and specificity metrics were used to assess the simulation results of the suggested monitoring system. It was demonstrated that the proposed DengueFog monitoring system with WRF outperforms the traditional classifiers.