A Cyclopropanol‐Based Strategy for Subunit Coupling: Total Synthesis of (+)‐Spirolaxine Methyl Ether.

Abstract

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ChemInform Abstract: Asymmetric Synthesis of Naturally Occurring Spiroketals

“…Philips and coworkers applied cyclopropanol-based strategy for the subunit coupling as shown in Scheme 15 [43]. The synthesis starts with the coupling of readily available olefin 68 with commercially available (R)-γ-valerolactone (67) to give cyclopropanol 66, according to the Kulinkovich cyclopropanation reaction [44].…”