A cytotoxic effect of human lactoferrin fusion with Fc domain of IgG

Lactoferrin, a Great Wall of host-defence?

“…Although holo- and apo-Lf often display similar bioactivities, the different localization of holo- and apo-Lf in the cell may suggest a different mode of action for Lf with different levels of iron saturation (Jenssen et al 2008 ). Also, it was reported that an FcLf adduct, created from hLf that was fused with an Fc domain of IgG, strongly induced expression of PI3K, with subsequent activation of the AKT/mTOR signaling pathway (Zaczyńska et al 2022 ). In addition, Lf not only provides ferric iron for mammals, but it can also be used as a donor by some pathogenic bacteria (Chan et al 2022 ).…”