A dandelion-like nanomedicine via hierarchical self-assembly for synergistic chemotherapy and photo-dynamic cancer therapy

Camptothecin-loaded supramolecular nanodelivery system based on amphiphilic calix[4]arene for targeted tumor therapy

“…Advances in recent research have demonstrated that liposomes and cyclodextrins can be used for the delivery of CPT to reduce its toxicity and promote its properties. [15][16][17][18][19][20][21][22][23] However, most of these carriers do not meet the requirements of a high drug-delivery efficiency, ease of dispersion, and controlled particle size, which are key to clinical translation. 24,25 Calixarene (CA), a crucial component of supramolecular families, is a supramolecular macrocyclic compound made of phenol units connected by methylene bridges, with an easy chemical modification of the upper and lower edges of the phenol units, an adjustable size, and conformation of the hydrophobic cavities in the structure.…”

“…Advances in recent research have demonstrated that liposomes and cyclodextrins can be used for the delivery of CPT to reduce its toxicity and promote its properties. 15–23 However, most of these carriers do not meet the requirements of a high drug-delivery efficiency, ease of dispersion, and controlled particle size, which are key to clinical translation. 24,25…”

Metastable FeSe2 nanosheets as a one-for-all platform for stepwise synergistic tumor therapy

“…Therefore, the utilization of comprehensive multimodal therapy to obtain sufficient antitumor activity at a low dose has been investigated, in which the PTT/CDT method has shown a higher therapeutic efficiency than monomodal CDT. [11][12][13] Although such comprehensive therapeutic strategies have shown good results, their complexity hinders the further promotion of their clinical application in this field. Therefore, it would be of great significance to fully exploit the inherent physical and chemical properties of nanomaterials to facilitate their concrete implementation in the clinic.…”